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Novartis AG

20.09.2022

Biomarker Therapeutic Area Lead/Biomarker Strategy

  • Switzerland
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Novartis AG

Novartis bietet innovative medizinische Lösungen an, um damit auf die sich verändernden Bedürfnisse von Patienten und Gesellschaften einzugehen. Novartis, mit Hauptsitz in Basel (Schweiz), verfügt über ein diversifiziertes Portfolio, um diese Bedürfnisse so gut wie möglich zu erfüllen: mit innovativen Arzneimitteln, Produkten für die Augenheilkunde und kostengünstigen generischen Medikamenten. Novartis ist das einzige Unternehmen mit weltweit führenden Positionen in diesen Bereichen.
Novartis bietet innovative medizinische Lösungen an, um damit auf die sich verändernden Bedürfnisse von Patienten und Gesellschaften einzugehen. Novartis, mit Hauptsitz in Basel (Schweiz), verfügt über ein diversifiziertes Portfolio, um diese Bedürfnisse so gut wie möglich zu erfüllen: mit innovativen Arzneimitteln, Produkten für die Augenheilkunde und kostengünstigen generischen Medikamenten. Novartis ist das einzige Unternehmen mit weltweit führenden Positionen in diesen Bereichen.

Biomarker Therapeutic Area Lead/Biomarker Strategy

Arbeitsort: Switzerland

mehr Infos zu diesem Job
Job ID 347997BR Sep 12, 2022 USA

Job Description

800 biomarker discovery and development projects, across more than 100 clinical studies, which generate 20 petabytes and 2 million patient-years of data! All waiting for you to unlock the next breakthrough in medicine.

Biomarkers are critical components of translational research, enabling robust therapeutic
and mechanistic hypothesis testing in early clinical development, and as precision medicine
enablers e.g. defining patient subpopulations, understanding disease heterogeneity, predicting therapeutic responses, and potential development as diagnostics.

As a BMD Therapeutic Area Lead (TAL) you will lead the disease area biomarker matrix team and be responsible for the development and implementation of “fit for purpose” biomarker strategies and providing an effective interface for transitioning projects from early to later stage clinical stages. You will be a core member of Global Biomarker and Diagnostic Teams, engaged in Translational Data Science teams, and provide therapeutic area line function review for clinical protocols. As a TAL you will lead efforts to identify, develop, and drive disease, mechanistic and compound biology that serves the precision medicine approaches for the multi-indication portfolio.

In the role of Therapeutic Area Lead in NIBR Biomarker Development (BMD) you will be responsible for:
Delivering clinical project and disease biomarker “fit for purpose” biomarker strategies and plans within one or more General Medicine disease indications (Cardiovascular and Metabolism, Hepatology, Renal, or Ophthalmology).
• Leading a dedicated matrixed group of biomarker subject matter experts and project team representatives to develop and oversee clinical project strategies, plans and timelines in partnership with line function leaders.

• Representing BMD line functions in Therapeutic Area Line Function committees for clinical protocol development
• Representing Biomarker Development on Cardiovascular and Metabolism, Hepatology, Renal, or Ophthalmology early and late Disease Area Decision Boards to identify, develop, and drive disease and compound mechanistic biology, and precision medicine approaches for the portfolio.•
• Leading strategic translational data working groups centered on integrating and analyzing large-scale patient muti-modal data sets ( omics, imaging, digital, etc.)to identify new indications, endpoints, and responsive patient subpopulations.
• Providing thought leadership with other BMD TALs to identify synergies and drive innovation across our large and diverse clinical portfolio.
• Implementing strategies in close collaboration with the BMD global organization which includes over 100 associates with expertise in all aspects of biomarker science i.e. genetics, genomics, molecular and cellular, digital devices, imaging and data
sciences

Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Minimum Requirements:

• MD , MD/PhD, or PhD degree required, plus additional PhD/postdoc or equivalent level research
• Deep understanding of clinical disease epidemiology that can be applied to questions of diagnosis, biomarker development and treatment monitoring strongly preferred
• Scientific excellence supported by recognized high quality publications; clinical and/or biological expertise in cardiovascular and metabolic diseases, hepatology, renal, or ophthalmology (Board certified or similar level preferred)
• Experience performing similar role within a pharmaceutical/biotechnology research company, clinical research organization or academic medical center
• Significant relevant experience after your MD/PhD/postdoc including quantitative expertise in biostatistics, bioinformatics, computer biology, statistical genetics, clinical imaging, machine learning, or data science; interpreting and publishing studies consisting of “omics” data e.g. genetics, genomics, proteomics; closely partnering with/leading data scientists
• Proven success in leading and partnering in multidisciplinary matrix teams across Pharma/biotech (clinical research thru healthcare applications), academic institutions, or commercial business functions
• Well-developed interpersonal skills with good presence and ability to influence and negotiate with senior leadership; experienced presenter and communicator
• Fluent in oral and written English; other languages e.g. German, French, Italian useful but not required

Position can be based in Basel, Switzerland or Cambridge, MA USA.

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Division NIBR Business Unit Translational Medicine Location USA Site Cambridge, MA Company / Legal Entity NIBRI Alternative Location 1 Switzerland Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to JobAccess Job Account