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      Novartis AG

      21.11.2022

      Senior Scientist II - Antibody Discovery Technology (80-100%*)

      • 4040Basel
      • Festanstellung 80-100%

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      Novartis AG

      Novartis bietet innovative medizinische Lösungen an, um damit auf die sich verändernden Bedürfnisse von Patienten und Gesellschaften einzugehen. Novartis, mit Hauptsitz in Basel (Schweiz), verfügt über ein diversifiziertes Portfolio, um diese Bedürfnisse so gut wie möglich zu erfüllen: mit innovativen Arzneimitteln, Produkten für die Augenheilkunde und kostengünstigen generischen Medikamenten. Novartis ist das einzige Unternehmen mit weltweit führenden Positionen in diesen Bereichen.
      Novartis bietet innovative medizinische Lösungen an, um damit auf die sich verändernden Bedürfnisse von Patienten und Gesellschaften einzugehen. Novartis, mit Hauptsitz in Basel (Schweiz), verfügt über ein diversifiziertes Portfolio, um diese Bedürfnisse so gut wie möglich zu erfüllen: mit innovativen Arzneimitteln, Produkten für die Augenheilkunde und kostengünstigen generischen Medikamenten. Novartis ist das einzige Unternehmen mit weltweit führenden Positionen in diesen Bereichen.

      Senior Scientist II - Antibody Discovery Technology (80-100%*)

      Arbeitsort: 4040 Basel

      mehr Infos zu diesem Job
      Job ID 354540BR Oct 24, 2022 Switzerland

      Job Description

      6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients.

      The NIBR Biologics Centre (NBC), in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

      In your role as Senior Scientist II, you will support the antibody discovery within a group in NBC in Basel, Switzerland. We are looking for an experienced, creative, and motivated team player. You will be part of a team responsible for the discovery of world leading therapeutic antibodies. Here you will work independently with various technologies like phage display, mammalian display to discover antibodies followed by their bio-chemical and functional characterization.

      Your responsibilities will include, but are not limited to:

      • Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, like phage display, mammalian display, FACS sorting, plate-based screening.
      • Analyse and screen selection outputs by Next Generation Sequencing (NGS).
      • Sub-clone hits into expression vectors and produce them at micro-scale in a high-throughput manner.
      • Characterize binders’ properties in various affinity and activity assays, like ELISA, FACS, Octet, epitope binning, reporter gene assays.
      • Engineer and improve binders by mean of affinity maturation or humanization.
      • Generate hypotheses to test, troubleshoot issues, design, and execute the next set of experiments.
      • Document the results in a detailed manner in laboratory journal and in internal databases.
      • Present research updates and participate constructively in working project teams and at laboratory group meetings.
      • Be part of a team of 3 scientists reporting to a lab head.

      Diversity & Inclusion / EEO

      Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

      Minimum Requirements

      What you will bring to the role:

      • Master’s degree in Biological or Biochemical Sciences with 5+ years of laboratory experience or recent PhD with 1-2 years of laboratory experience.
      • Ideally 2-5 years of industry experience, in antibody discovery technologies, including at
      o least one technology like phage, yeast and/or mammalian display.
      • Good experience in flow cytometry analysis as well as sorting is mandatory.
      • Knowledge in antibody engineering is a plus.
      • Solid background in molecular biology, bacterial and mammalian cell biology, biochemistry, affinity, and activity assays.
      • Hands- on experience with data management and sample storage system.
      • Excellent oral and written communication in English and interpersonal skills.
      • Self-motivation, enthusiasm, and scientific curiosity.

      What Novartis can offer you?
      In addition to outstanding benefits and competitive salary, you will:
      Be part of a team that is generating high quality therapeutic antibodies to help patients.
      Gain experience with a variety of cutting-edge antibody selection and screening techniques.
      Work with the latest technologies and instrumentation.
      Be part of a world-class organization dedicated to providing solutions to un-met medical needs.
      Join an organization that is committed to your development and advancement.

      Why consider Novartis?
      769 million lives were touched by Novartis medicines in 2020, and while we are proud of this, we know there is so much more we could do to help improve and extend people’s lives.
      We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

      We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity, and flexibility. And we can reinvent what is possible, when we collaborate with courage to tackle the world’s toughest medical challenges aggressively and ambitiously. Because the greatest risk in life, is the risk of never trying!

      Imagine what you could do here at Novartis!

      *Restrictions on flexible working may apply and will be discussed at interview stages as requiredDivision NIBR Business Unit BIOLOGICS NIBR Location Switzerland Site Basel Company / Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to JobAccess Job Account