Novartis Pharma AG

Job ID REQ-10006204 May 10, 2024 Switzerland Summary -Designs and provides oversight of clinical research programs. Builds relationships with key opinion leaders and applies their input to enhance study design and protocols. Serves as medical/scientific consultant to marketing or research project teams and government regulatory agencies. Establishes the criterion essential for determining the safety, efficacy, and medical utilities. Interprets results of Phase I-III investigations in preparation for new-drug or medical device application. May serve as safety expert for individual clinical projects. May be responsible for post marketing studies About the Role Are you prepared to embrace a distinctive opportunity as the Global Program Clinical Head - Dermatology at Novartis? As the overseer of Global Clinical Team(s) (GCT), you will have a vital role in creating, implementing, and carrying out clinical development programs. Your contributions will aid in crucial decision-making, meeting regulatory standards, and ensuring market accessibility, while also allowing you to contribute to the overall strategy in the field of dermatology. Join our exceptional team and make a substantial difference in this specialized area. Your responsibilities will include, but are not limited to: Leading the GCT and representing Clinical Development on the Global Program Team (GPT) Leading the creation of clinical components of key documents such as Clinical Trial Protocols (CTPs), Investigator’s Brochures, Clinical Study Reports (CSRs), and regulatory documents Supporting registration, market access, commercialization, and maintenance of product licenses Serving as the Clinical Development Representative on NIBR clinical/project teams Leading the development and execution of the clinical strategy post-DDP Supporting Business Development & Licensing (BD&L) activities where applicable To be successful in this role, you should meet the following minimum requirements: MD or equivalent (preferred), PhD, or PharmD degree required, with equivalent experience also considered. Specialization in a subspecialty may be needed. Board certified Dermatologist with 6 years (MD or equivalent) or equivalent experience, 10 years (PhD or PharmD) or equivalent experience of involvement in clinical research or drug development in an industry environment spanning clinical activities in Phases I through III/IV, including submission dossiers. Advanced knowledge of assigned therapeutic area preferred, with the capability to innovate in clinical development study designs 5 years of people management experience required Thorough knowledge of Good Clinical Practice, clinical trial design, statistics, and regulatory/clinical development process Experience with submissions and health authorities required At Novartis, we value our employees and strive to provide exceptional benefits and rewards. You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards We are committed to building an outstanding, inclusive work environment and diverse teams that are representative of the patients and communities we serve. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit Pharmaceuticals Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Alternative Location 1 Ireland Alternative Location 2 United Kingdom Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Apply to Job(link is external) Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID REQ-10005186 May 09, 2024 Switzerland Summary When you are a part of the Global Operational Excellence team, you'll have countless opportunities to develop your career, as you’ll be surrounded by people you can learn and help you reach your full potential. Our team is seeking a Global Operational Excellence, Executive Director. This role is a cross-disciplinary pioneer with a positive personality, entrepreneurial mindset, and an uncompromising drive to transform drug development and improve lives. Defined by an exceptional ability to build relationships, this role is a thought-leader who can drive highly performant partnerships with senior executives across divisions, challenge the status quo through cross-disciplinary thinking and create new opportunities for organizational impact. In this role you will be accountable for delivering strategic imperatives for Development by taking ownership for the creation, planning and operationalization of key cross-division improvement programs. You will be expected to enhance the executional certainty of a portfolio of change initiatives by deploying best-in-class project management practices, successfully leading multi-disciplinary teams (influencing through the matrix) and integrating insights from internal and external specialists. The self-motivation to develop world-class knowledge, willingness to mentor junior associates, and collaborate selflessly are essential. About the Role <b>Major responsibilities:</b> Your responsibilities include, but are not limited to: Identify, propose, and deliver pivotal initiatives for Development as improvement projects using data as the performance baseline. Accountable for the faultless delivery of large-scale improvement projects that employ project management standard processes to enhance certainty of success. Structure ambiguous problems and take action to solve them, with clear linkage to Development principles, strategy and priorities. Synthesize clear takeaways from sophisticated information into outcomes and recommendations using both qualitative and quantitative methods. Lead multi-disciplinary teams, influencing without authority, to develop the best solution and move partners and the organization to act. Establish trust-based relationships with senior leaders and partners to better serve their organizations. Deploy superior communication skills to transmit information effectively to all audiences, including senior leaders, in a structured manner. Drive project teams and organizations to accurately improve operating model design, process simplification, data & technology enablement, and financial success, whilst ensuring quality standards and regulatory compliance. Proactively bring pioneering thought leadership, technology and processes with intent to bring more drugs to the patients faster. Maintain awareness of process improvement methodologies. Build a deep talent bench for Novartis by driving top-level talent acquisition, succession planning and development of associates across GDD and Divisions are working to their full potential and to build a strong talent pipeline for Novartis. Strengthen OpEx by developing an One Development culture, change excellence management, fostering innovation, and building best-in-class teams that fully exploit “Drug Development” opportunities, internal systems, programs, processes and tools. <b>Minimum requirements:</b> What you'll bring to the role: Bachelor’s degree in life science and/or in business administration with 12 – 15 years of experience working in the pharmaceutical industry, life sciences / drug development or equivalent. Advance degree is preferred (e.g. MBA desired or equivalent) International and/or cross-disciplinary background; appreciation of sophisticated operating models (i.e. matrix) and shown ability to influence without direct authority. Sophisticated and credible at leading senior executive relationships. Consistent record of generating new partnerships that lead to successful engagements. Outstanding interpersonal communication skills - both verbal and written: Ability to present complex ideas effectively. Exceptional program/project management skills by qualification, training, and experience, and awareness of methodologies (e.g. IQP, Lean six sigma, Scrum, Agile ...); able to adjust to multiple demands, shifting priorities and unexpected events while maintaining a positive work attitude Seasoned cross-functional leadership skills and proven ability to develop impactful teams from a diverse set of backgrounds and implement solutions for business challenges within a highly matrixed organization. Team-orientated and collaborative approaches; outstanding listening skills and the ability to lead through influence to optimize contributions from team members as individuals and members of a cohesive team. Strong analytical skills, critical thinker, and problem-solving abilities to structure ambiguous problems and take action to solve them. Deep understanding of drug research and development process; expertise in improvement methodologies. Certified Agile/ Scrum/ Lean six sigma or blackbelt is preferred. Willingness to travel. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit Pharmaceuticals Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Apply to Job(link is external) Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID REQ-10001988 Apr 24, 2024 Switzerland Summary This role is a highly technical and a professional position responsible for collaborating with multi-discipline research programs by providing high quality & consistent in-vivo scientific/technical support, by planning and conducting routine standard discovery pharmacokinetic studies in rodents. About the Role 6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. Your responsibilities: Your responsibilities include, but are not limited to: • Plan and conduct routine standard discovery PK studies in rodents including formulation preparation, compound application and sample collection. On occasion, perform microsurgeries in rat including anesthesia and analgesia handling. • Record, document and archive experimental details based on ALCOA+ principles with a high level of quality, integrity and ethics. • Maintain a well-organized laboratory environment, including inventory management, equipment maintenance, and adherence to safety protocols. • Collaborate with colleagues to optimize laboratory workflows and ensure efficient use of resources. • Be a pro-active and solution-oriented team member, actively contributing to new method development and refinements. • Comply with rules and regulations (e.g. Swiss Animal Welfare law, 3R principles, HSE regulations) on a daily business. • Team player, excellent in collaboration, coordination, and communication skills with other scientists (within and outside department) are mandatory. Fostering an atmosphere of mutual respect. What you’ll bring to the role: • Completed education (apprenticeship) as in vivo Laboratory Technician in Biology or related discipline. • Training in animal handling (e.g. valid accreditation with LTK1 course, FELASA Cat. B training or equivalent training is of advantage). • Good skills in animal handling, anatomy, anesthesia, basic surgical knowledge in rodents and a good level of proficiency in various rodent dosing techniques. • Fluency in English (additional German language skills advantageous). • Good knowledge of Microsoft Office tools. Why consider Novartis? 750 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives? We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges. We are Novartis. Join us and help us reimagine medicine. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regulär Shift Work No Apply to Job(link is external)

Job ID REQ-10005133 May 07, 2024 Switzerland Summary We are looking for a Postgraduate to join the Analytical Characterization (AC) team in Basel, Switzerland, within the Novartis Technical Research and Development (TRD) Biologics Analytical Development unit. The successful applicant will be part of the mass spectrometry group working in a highly collaborative and scientific environment focusing on the characterization of novel biologics entities. About the Role Preferred start date / 1st of July 2024 onwards Duration: Initial contract up to two years Your responsibilities: Provide support to the development of therapeutic protein characterization methods by liquid chromatography coupled to mass spectrometry (LC-MS) based workflows Implementation of (semi-) quantitative methods for the monitoring and reporting of targeted product quality attributes as well as new peaks of therapeutic proteins using state-of-the-art LC-MS equipment and software, by e.g. multi-attribute method (MAM) or targeted LC-MS assay Plan and perform automated protein enzymatic digestion on a robotic system Perform project-specific method qualification and assessment of method robustness, where applicable Documentation of experiments and results in electronic systems What you’ll bring to the role: Education: MSc in Biotechnology, Biochemistry, Analytical Chemistry or related field. Relevant work experience would be an asset. Languages: Strong communication skills in English; proficiency in German or French would be an asset Experience/Professional requirements: Strong hands-on experience in liquid chromatography (HPLC and UHPLC e.g. VanquishTM) Hands-on experience in protein sample preparation and analysis (e.g. peptide mapping by LC-MS) preferably using automated sample preparation on a robotic system (e.g. Hamilton STARlet) Strong theoretical knowledge of protein biochemistry and protein posttranslational modifications Theoretical knowledge and previous experience working with mass spectrometers (e.g. Orbitrap and Q-ToF analyzers) Experience desired with selected reaction monitoring (SRM), parallel reaction monitoring (PRM), selected ion monitoring (SIM), or new peak detection (NPD) Experience with Chromeleon and/or Genedata Expressionist would be an asset Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com, and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit Pharmaceuticals Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Job Type Full time Employment Type Early Talent (Fixed Term) Shift Work No Apply to Job(link is external)

Job ID 393600BR Mar 21, 2024 Switzerland About the Role Location: Basel, Switzerland Fulltime, Onsite, #LI-onsite Novartis' Biomedical Research division is our Innovation engine. We have bold objectives to transform the lives of millions of people living with diseases and conditions and unmet medical needs. Applications are invited for a Senior Research Scientist to carry out cutting-edge oncology drug discovery pharmacology research. We seek an experienced, motivated and ambitious individual with a passion for in vivo oncology research. You will join the Radioligand Therapy (RLT) team to develop and validate novel targets in our world leading Oncology portfolio. The position is based in Basel, Switzerland. The ideal candidate should have a passion for working with rodents and a drive to perform in vivo oncology pharmacology studies including micro-surgeries, compound administration and preparation of samples for ex vivo analysis. Hands-on background performing small animal imaging modalities such as PET/SPECT/uCT or in cell biology techniques is a plus. The successful candidate will work collaboratively as an integral part of global projects and be an active member of lab and project teams. Responsibilities include but are not limited to: • Develop and characterize novel in vivo oncology models • Perform efficacy studies with cutting edge radioligand therapies • Perform biodistribution studies and metabolites analysis • Perform pre-clinical imaging studies including PET/SPECT/uCT • Perform and/or support colleagues with various in vitro and ex vivo activities (e.g. cell culture, flow cytometry, IHC, immunofluorescence, PCR, Western blotting) Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements What you will bring to the role: • Masters degree in pharmacology, cell biology, medical physics, bioengineering, biotechnology or related field or Bachelors degree with equivalent experience. Please note that for this position we do not require a PhD qualified candidate at this time. • Practical work experience in biomedical research from an industry or academic laboratory • Experience in performing animal studies (animal handling, drug application, sampling, animal welfare regulations, small laboratory animal surgery) • Self-motivated, proactive, and able to work independently Desirable requirements • Knowledge and experience of standard cell biology techniques is desirable: cell culture, IHC, immunofluorescence, flow cytometry, quantitative real-time PCR, transfection, western blotting, etc., • Highly collaborative team player that enjoys working across multi-disciplinary teams • Excellent organizational and communication skills • Knowledge of cancer biology Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network *Please note that restrictions on flexible working may apply and will be discussed at interview stage if applicable Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Biomedical Research Business Unit Oncology NIBR Location Switzerland Site Basel Company / Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

About the Role 6000! That's the number of associates in the BioMedical Research (BR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients! Based on our understanding of cancer at the molecular, cellular and organismal levels, Translational Clinical Oncology or TCO will design and execute innovative exploratory clinical trials in order to develop the next generation of highly effective therapeutics that transform the lives of patients with cancer. This role is to provide strategic medical guidance and lead the development of experimental oncology agents in the TCO portfolio, from the Phase of preclinical development, continuing through clinical First in Human and Phase 1b/2 studies. Your responsibilities will include but are not limited to: • Acts as a clinical leader responsible for assigned global clinical program(s) -driving medical strategy implementation and operational deliverables for investigational products in a defined therapeutic area • Ensure effective cross-functional communications to align with global strategy and leads the development of clinical sections of trial and program level regulatory documents • Acts as the medical expert, engages interactions with external stakeholders (e.g., regulatory authorities, key opinion leaders, data monitoring committees, advisory boards etc.) and internal NVS stakeholders • Contributes to medical/scientific training of relevant Novartis stakeholders. May serve as speaker for medical/scientific training -May serve on or lead global initiatives (e.g., process improvement, training, SOP development, other Clinical Development line function initiatives) • Experience leading early and/or late phase Oncology clinical programs with radiopharmaceuticals from the pharma/biotech industry plus credible experience from an academic medical center. In case of no industry experience then significant academic experience in Radio Oncology with credible PI/co-PI clinical study leadership • Track record of significant contributions to your field over time, creating new concepts and seeking out new clinical discovery opportunities / approaches Role Requirements ∙ Medical degree, oncology board certified preferred, and PhD level basic Science or equivalent expertise ∙ Essential requirement is radiation expertise (radiation therapy specialist) or experience within RLT in industry. ∙ ≥ 3 years technical, operational and managerial experience in planning, executing, reporting and design of clinical trials studies in a pharmaceutical company, academic centre or contract research organisation ∙ Good knowledge of Good Clinical Practice, clinical trial design, statistics, regulatory processes, and global clinical development process ∙ Good knowledge of oncology and experience in early clinical development preferred. ∙ Good communication, writing and organization and skills, fluent in English written and spoken Why consider Novartis? Flexibility: Novartis offers a flexible working environment for lab-based associates Culture: Novartis is a curious, empowered, inspired, unbossed, collaborative environment Growth and development: Associates are encouraged to take ownership of their growth and development with several cross-functional development (technical and leadership) options to explore Total rewards: Novartis offers competitive: salaries, short and long-term incentives, health and retirement options, paid-time off, and many other benefits. Why Novartis? 766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external)

Job ID REQ-10001567 Apr 29, 2024 Switzerland Summary Novartis is deeply committed to transforming the lives of people living with solid tumors, blood cancers and serious or life-threatening blood disorders. We believe that anyone living with these conditions has the right to a life free from pain, free from symptoms and free from disease - this is our vision for the future. In Clinical Development Oncology & Hematology, our aim is to design innovative, patient friendly clinical development plans to rapidly bring outstanding treatments to patients, caregivers and healthcare systems. We are seeking to develop treatments for Lung, Breast & Prostate Cancers, MDS & AML, CML and sickle-cell disease, and are pushing the boundaries of innovation with CAR-T and Radioligand therapies. About the Role Are you a driven and ambitious individual looking for an exceptional opportunity in the field of clinical development? Novartis, a world-class focused medicines company, is seeking a Clinical Development Medical Director to join our team. In this role, you will play a crucial part in our research efforts and contribute to the development of groundbreaking medical innovations. Responsibilities: Lead and oversee clinical development programs, ensuring detailed execution and adherence to regulatory standards Create and implement clinical trial protocols, while ensuring compliance with ethical guidelines and widely recognized standards. Work closely with colleagues from different departments and external partners to establish study goals, desired outcomes, and strategies for analyzing data. Manage and mentor a team of clinical research professionals, fostering a collaborative and inclusive work environment Provide medical expertise and guidance throughout the development lifecycle, from early-phase trials to post-marketing activities Act as a key point of contact for investigators, regulatory authorities, and other relevant parties Proactively identify and address any potential risks or challenges, implementing appropriate mitigation strategies Contribute to the publication of study results, ensuring high-quality and impactful scientific publications Stay up-to-date with the latest advancements in clinical research and therapeutic areas relevant to our portfolio Requirements: Medical degree and specialized training in the relevant therapeutic area Proven experience in clinical development within the pharmaceutical industry or academic research Strong knowledge of regulatory requirements and standards, including GCP and ICH guidelines Excellent leadership and communication skills, with the ability to effectively collaborate with cross-functional teams Track record of successfully implementing clinical trials, from study design to data analysis and reporting Ability to work in a fast-paced and dynamic environment, managing multiple priorities and competing deadlines At Novartis, we believe in fostering a diverse and inclusive workplace. We are an equal opportunity employer and value the contributions of all our employees. We are committed to providing reasonable accommodations/adjustments to individuals with disabilities throughout the recruitment process. If you require any accommodations, please let us know and we will be happy to assist you. If you are motivated by the opportunity to make a significant impact in the field of clinical development and contribute to the advancement of medical science, we encourage you to apply. Join our team at Novartis Ag and be part of a world-class organization dedicated to improving lives through groundbreaking research. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit Pharmaceuticals Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Alternative Location 1 India Alternative Location 2 Ireland Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Apply to Job(link is external) Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID 379986BR Mar 22, 2024 Switzerland About the Role 13! The number of medicines Cardio Renal Metabolic (CRM) diseases currently in development at Novartis. Novartis is deeply committed to transforming the lives of people living with cardiovascular, renal and metabolic diseases. We believe that anyone living with these conditions has the right to a life free from pain, free from symptoms and free from disease - this is our vision for the future. Our mission is to reimagine medicine to extend and improve people’s lives – and our overall company strategy to achieve this is to Focus Novartis as a leading medicine company powered by data science and advanced therapy platforms The (Sr)* Global Program Clinical Head (GPCH) is the global clinical leader responsible for one or more clinical programs across indications, involving one or multiple compounds. As the leader of Global Clinical Team(s) (GCT), the GPCH is accountable for the design, implementation, and execution of a clinical development program(s) to support decision milestones, regulatory requirements, market access and owns the risk benefit-assessment for the program(s). The GCPH contributes to the disease area strategy. Your responsibilities include, but are not limited to: • Leading the GCT and representing Clinical Development on the Global Program Team (GPT) • Leading the creation of clinical components of key documents (e.g., Clinical Trial Protocols (CTPs), Investigator’s Brochures, Clinical Study Reports (CSRs), regulatory documents including maintenance of product licenses, registration dossiers, value dossiers, pharmaco-economic dossiers) with high quality and consistency with Integrated Development Plan (IDP) and Target Product Profile (TPP). Supports registration, market access, commercialization, and maintenance of product licenses (e.g., Core Data Sheet, Periodic Safety Update Report, clinical benefit-risk assessment for license renewals) for the compound(s) • May serve as the Clinical Development Representative on NIBR clinical/project teams to drive transition of pre-PoC (Proof of Concept) projects to Development Decision Point (DDP) • Post-DDP, leading the development and execution of the clinical strategy. Developing an endorsed (IDP) in line with the Target Product Profile (TPP) which is designed for successful global regulatory approval/market access for one or multiple treatment indications and/or multiple programs • Where applicable, supporting Business Development & Licensing (BD&L) activities Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements • MD or equivalent (preferred), PhD, or PharmD degree required, specialization in a subspecialty may be needed. Advanced clinical training/knowledge in disease area (renal) preferred with 6 years (MD or equivalent) • 10 years (PhD or PharmD) of involvement in clinical research or drug development in an industry environment spanning clinical activities in Phases I through III/IV, including submission dossiers • Advanced knowledge of assigned therapeutic area preferred, with the capability to innovate in clinical development study designs that provide relevant evidence to decision-makers, and to interpret, discuss and present clinical trial or section program level data • 5 years people management experience required; this may include management in a matrix environment • Thorough knowledge of Good Clinical Practice, clinical trial design, statistics, and regulatory/clinical development process • Experience with submissions and health authorities required. * Final job title (Senior GPCH, Band 2 / GPCH, Band 2) and associated responsibilities will be commensurate with the successful candidates’ level of expertise. **some restrictions to flexible working models may apply and will be discussed at interview if applicable Why consider Novartis? 236 million. That’s how many lives our products touched in 2022. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives? We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges. Imagine what you could do at Novartis! Commitment to Diversity & Inclusion: Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit CARDIO-RENAL-METAB GDD Location Switzerland Site Basel Company / Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

Job ID 392731BR Feb 27, 2024 Switzerland About the Role 350 million! That is the estimated number of patients worldwide suffering of atopic dermatitis or psoriasis. Join Novartis to help find the right drugs to transform and improve patient's lives all around the world. You will provide medical and scientific leadership and expertise in a role that significantly impacts the entire Novartis Dermatology drug development pipeline. • Drive success of early global programs, develop and implement strategies to achieve clinical Proof of Concept or Proof of Mechanism to enable transition to further development • Drive success of late global programs when appropriate by developing and implementing strategies that lead to clinical pharmacology, design of mechanistic studies and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling • Provide scientific expert assessments and support for in-licensing opportunities, including due diligences Your responsibilities: Translational Medicine early clinical projects: In collaboration with your Translational Medicine Therapeutic Area Head or other Translational Medicine Experts • Develop high value decision-strategies for the Translational Medicine component of drug development projects from Research to clinical Proof of Concept or Proof of Mechanism in a single or multiple indications, including Parallel Indication Expansion-Proof of Concepts - Represent TM and lead global project teams through First in Human and Proof of Concept phase to drive strategy that enables development - In collaboration with research scientists, contribute to the proposal of new targets or indications for existing compounds; identify, develop, and implement strategy for preclinical support of clinical program-related scientific objectives. This includes assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications, and other relevant activities - Responsible for implementing studies during the Proof of Concept phase by providing medical and scientific leadership and expertise to all line functions on the project team. This may include methodology studies to identify and validate novel endpoints for early decision making. - Responsible for clinical portions of the Integrated Development Plan, including the Clinical Development Plan and Clinical Pharmacology Plan • Accountable for compound and disease related biomarker strategies, working closely with Biomarker Experts in implementation • Develop and implement study protocols for different types of clinical studies (First in Human, Proof of Concept, mechanistic and safety studies), and other documents such as investigators brochures. • Responsible for clinical monitoring and integrated safety data review during and after the live phase of a study • Provide medical and scientific leadership and expertise to all line functions on the study team • Leadership - Lead study-specific teams/ clinical trial teams - Represent TM or lead BR project teams • Represent clinical Translational Medicine aspects to Health Authorities and other stakeholders (e.g. payers, patient advocacy groups) • Represent clinical Translational Medicine in reviews of external opportunities • Oversee publication and external presentation of study results • Innovation: Champion and drive new clinical compound characterization opportunities and profiling approaches • Contribute to initiatives that drive innovation, quality, and efficiency across Translational Medicine Translational Medicine late-stage clinical projects: In collaboration with your Translational Medicine Disease Area Head: • Drive analysis of studies and present results to relevant decision boards • Communicate clinical team matters to Global Project Teams, relevant Novartis BioMedical Research and Global Development boards, and other Novartis Boards as required. • Evaluate clinical centers and foster communication with crucial collaborating investigators, regulatory authorities, and other stakeholders • Provide support for dose selection, design and other clinical pharmacology matters throughout the development cycle • Responsible for content and authoring of documents needed for submission documents with Translational Medicine input (CO, SCE, SCS, SCP, SBP) of NDAs, sNDAs, MAAs, BLAs from regulatory submission through drug registration, including advisory committee and scientific advice group meetings Key Performance Indicators: • Delivery of proposed Development Candidates, Integrated Development Plan Approval and Development transition point milestones, and early clinical study results, according to timelines • Team leadership skills that create high performing teams and drive efficient conduct of innovative, interpretable clinical results • Strong adherence to and modeling of Novartis values and behaviors • Quality of contribution to disease area strategy discussions and contribution to Clinical Pharmacology plans / Profiling strategy discussions and external collaborations Matrix people responsibility per project: 5-8 cross-functional members from within Translational Medicine plus other line functions per project team Impact of this role? • Design and implementation of early Clinical Development Plan and studies according to the Integrated Development Plan / Clinical Development Plan / Clinical Pharmacology Plan enabling efficient and rational decision-making, high probability of fast drug registration, favorable drug label and high competitiveness of compounds • This role has a key impact on the entire Novartis pipeline, transitioning programs from preclinical through early clinical and ultimately to full development via First in Human, Proof of Concept, and driving the program after Proof of Concept by delivering key Profiling data to support regulatory submissions • Recognized Expert in field, drives project team clinical strategy. Works globally across Novartis as well as country organizations as appropriate Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements What you’ll bring to the role: • Medical Degree and additional PhD/post-doctoral equivalent immunology research • Specialized further training (board certification) and / or clinical research experience in dermatology / immunology preferred • Advanced / business-level / fluent English (oral and written) • Recognized for medical expertise: demonstrated excellence and clinical / patient expertise in dermatology / immunology • Recognized for scientific expertise: respected by colleagues internally and externally, you’ve made significant contributions to your field and created / established new concepts; record of high quality publications in international scientific journals. • Previous relevant & significant clinical study experience: either from pharma/biotech leading early phase clinical trials; a senior role within a CRO responsible for leading the medical relationship with Sponsors; from a relevant academic medical center with PI & co-PI clinical trial experience. You are used to working independently and within teams including scientists and non-scientists on study planning and execution, demonstrating competence in a broad range of project and more strategic planning skills • Excellent written and oral communication/presentation skills, used to distilling and effectively conveying significant messages to different audiences Your behavioral characteristics • Demonstrated passion for treating patients and science • Strategic thinker: you have created major innovations, networked with and influenced external medical leaders with your clear and logical presentation of complex strategic issues • Innovation: a curious mind and a natural instinct to seek out new clinical discovery opportunities and clinical study approaches • Results-driven self-starter and decision taker; good planning, prioritization, problem solving and organizational skills; strong cooperative team player, flexible in a changing environment; Resilient, energetic and enthusiastic; responding constructively to challenging new ideas and input This position is written for Director - we can hire Executive Director for those with significant Pharma careers, or Associate Director if you have limited clinical study experience or a less established scientific record but have already demonstrated impactful new thinking and innovative clinical & scientific approaches within your career. ABOUT TRANSLATIONAL MEDICINE: Translational Medicine is a global group of scientists and Physicians working at the pre-clinical and early clinical stage of drug discovery. Our Physician-Scientist Discovery & Profiling group drives innovative and cutting–edge science from Discovery to the market through the selection, profiling and effective global development of successful medicines. The group closes the gap between preclinical research and clinical development and integrates clinical science into the discovery and preclinical development phase. Our Translational Medicine concepts are driven by medical needs of the patient and the concept of personalized medicine, tailoring the drug, its dose and dosing regimen in such way to the patient that the clinical response is optimal in terms of efficacy and safety. We focus from identification of drug targets (molecular pathways relevant to disease) up to the completion of Proof of Concept (Phase IIa studies). Our Translational Medicine Experts are part of preclinical project teams in all drug discovery phases and help design the pathway for First in Human studies (healthy volunteer) that bridge to studies in the patient population. They have the comprehensive responsibility for designing and executing the early clinical drug development phase together with a project team from researcher, biomarkers, biostatistics, modeling and simulation, toxicology, technical experts and the clinical trial teams. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Biomedical Research Business Unit Translational Medicine Location Switzerland Site Basel Company / Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

Job ID 393805BR Mar 14, 2024 Switzerland About the Role Location: Basel, Switzerland #LI-Hybrid Getting people the medicines they need presents a series of complex challenges that can only be overcome with curiosity, determination and the support of a strong, united team. Join us and you can be part of that team. As the Head Legal, Secretary Pension Fund Board of Trustees, you will carry out the statutory activities of the Pension Fund in accordance with legal and regulatory requirements including accounting, controlling, financial and statutory reporting and information Your key responsibilities: • Support plan changes and maintenance of pension scheme in line with personnel policy of the Company • Ensure compliance with all legal and Board-issued requirements • Ensure safe and efficient asset management as a member of the Investment Committee • Analyse and follow-up on legal developments and ensure impeccable application within the Pension Funds • Continuously train and advise the Pension Funds’ associates, members of the Boards of Trustees, company representatives and insured members and pensioners according to their respective needs • Organize and moderate meetings and workshops of the Boards of Trustees • Represent the Pension Funds in legal matters and maintain contact to authorities • Act as Secretary and member of the Novartis Pension Board Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements Essential Requirements: • Several years of practical experience as a lawyer, preferably in the field of occupational pensions or another branch of social insurance • Degree in law (BLaw, MLaw, lic. iur.) and/or other further legal training with a comparable focus • Proficiency in German and English (written and spoken) • Efficient, precise and structured way of working with a flair for figures • Collaborative and solution-orientated personality with a strong service mentality • Knowledge in the field of investment management paired with strong negotiating skills and experience and joy in giving trainings and facilitating workshops Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division People & Organization Business Unit P&O CoE Total Rewards Location Switzerland Site Basel Company / Legal Entity Pensionskasse Novartis Functional Area Human Resources Job Type Part Time Part Time percentage 80 Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

Job ID 393658BR Mar 06, 2024 Switzerland About the Role 100,000+ That’s how many patients participate in our clinical trials at any given time. GCO is Novartis’ powerhouse of Global Clinical Operations, redesigned to enable faster trial recruitment and enhanced trial delivery resulting in more timely access for patients to potential novel treatments. Every day, we are the link between science and medicine – imagine the impact you could have as Clinical Operations Program Head! #GCO The Clinical Operations Program Head (COPH) is accountable to deliver data-driven, actionable operational and strategic insights for execution of a clinical development program and all associated trials by representing GCO at the Global Clinical Team (GCT) as well as at the Global Program Team (GPT). The COPH actively contributes to the GPCH’s and GCT’s strategic objective to achieve their own overall accountability for delivering the clinical program. The COPH provides the operational perspective to the Clinical Development Plan and to trial protocol design, ensuring that GCT/GPTs are aware of operational considerations and options, and that these are adequately reflected in planning. The COPH is the single point of contact for a trial/program within GCO and partners closely with key members of the GCT/GPT such as GPCH, GPH and other key communities to ensure best collaboration with operations to drive overall success of our programs and trials. The COPH leads the GCO sub-team to determine the GCO operational input to planning prior to any given development tollgate and to prepare the Operational Execution Plan (OEP), which is authored and owned by the COPH. The OEP incorporates both data-derived insights as well as country insights which enable informed decision-making, identify complexity, enable the generation of risk mitigation plans to reduce chances of delays, allow easier adaption of actions, and ensure transparency of the GCO operational position and the downstream delivery of program and trial milestones. Experienced leader guiding members of the organization through the GCO organizational evolution, the evolution of new “product aligned” ways of working and of our overall culture. He / she champions a product oriented agile mindset, fostering a culture of experimentation combined with accountable delivery and overall high performance. Your Key Responsibilities: 1. Accountable for the operational delivery of the clinical development program and is responsible for the overall operational execution of the clinical program and related trials, as aligned with the IDP/CDP. 2. Single GCO point of contact for assigned clinical development program and related trials. 3. Key partner to GPCH during strategy, planning and execution stage of the program and related trials ensuring that the clinical science and strategy are consistently harmonized with an operationally feasible approach within the OEP-defined operational boundaries, so that the trials generate reliable information to answer the research questions and support decision making while protecting study participants. 4. In partnership with GCPH and other GCT members, actively offer operational insights and options to contribute to the program and trial strategy, in particular with respect to study design and protocol optimization and timelines planning. 5. Leads the GCO sub-team to ensure the creation of best-in-class OEPs and to ensure that progress of the assigned programs and trials is on track and that operational risks are identified and mitigated proactively. The COPH further leads the GCO sub-team to ensure monitoring of the status of the progress of the clinical trials in line with the OEP and to deploy mitigation measures whenever needed to ensure overall trial success. 6. Leads the GCO sub-team taking accountability for the success of the team and of each team member by implementing “agile” and “product-oriented” ways of working. 7. Holds accountability for the operational delivery of the assigned program and related clinical trials and for all related strategic planning, prioritization of activities within that program. 8. Is a key contact to senior leaders in GCO and beyond. Empowered to manage stakeholders, resolve conflict, and facilitate agreements Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements What You’ll Bring to the Role: • Bachelors in life science/healthcare required; Advanced degree or equivalent education/degree in life sciences/ healthcare preferred (PhD/MD/ PharmD/ Masters). • Fluent English (oral and written) • 10 or more years of experience in pharmaceutical clinical drug development. • Experience in managing associates globally and in management in a matrix organization. • Proven ability to lead cross functional matrix teams applying product-oriented agile ways of working. • Strong leadership, interpersonal and problem-solving skills. High resilience and ability to advocate and implement new ways of working. • Has ability to understand data and insights with ability to communicate this succinctly and accurately • Extensive knowledge of clinical development processes, preferably extensive knowledge of Novartis late-stage development processes or high likelihood to develop it within 6 months after appointment. • Proven ability to lead in times of organizational transformation and to lead across organizational boundaries. • Strong organizational awareness and stakeholder management skills. • Strong knowledge of therapeutic area or high likelihood to develop it within 6 months after appointment. Strong matrix management skills for bridging stakeholders (business, scientific, technical) • Strong relationship-building skills; can influence, negotiate with and motivate executive leadership • Strong tolerance for ambiguity, willingness to adapt, willing to speak-up and challenge • Embraces a culture of diversity, inclusion, quality, innovation and driving forward with integrity at all times Why Consider Novartis? 766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity, and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity, and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit GCO GDD Location Switzerland Site Basel Company / Legal Entity Novartis Pharma AG Alternative Location 1 United Kingdom Alternative Location 2 Ireland Alternative Location 3 India Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

Job ID REQ-10000145 Apr 26, 2024 Switzerland Summary Are you skilled in Analytical Method Development? Have you developed analytical methods based on QbD principles for both, human and automated sample preparation? Have you used automated solutions for method development? Do you thrive on challenges and enjoy creating new physicochemical methods for biopharmaceutical molecules? Would you be willing to mentor and support your colleagues in their professional growth? Are you attracted to living in a vibrant region of Europe with abundant cultural and outdoor activities? If you answered "yes" to all of these questions, then we want you to join the Novartis Process Analytical Sciences team in Basel, Switzerland. Our team develops Biologics drug substance and drug products, from candidate selection to launch, emphasizing agility, innovation, and scalability to best serve our portfolio, partners, and patients. About the Role As Senior Method Expert you will be part of the Method Expert Team of Process Analytical Sciences at our TRD Biologics site in Basel. Your responsibilities include, but are not limited to: 1) Method Development and Optimization using Quality-by-Design (QbD) Principles : Applying QbD principles, drive and execute the physicochemical analytical (PCA) method development and optimization of assigned pipeline projects for all relevant sample matrices (Drug Substance, Drug Product, Intermediates). Design experiments, perform risk assessments, and utilize statistical tools to develop robust and reliable analytical methods. 2) Method trending: Ensure appropriate trending of method performance parameters by establishing trend/control charts for relevant methods. 3) Advanced Instrumentation and Technology : Leverage advanced analytical instrumentation and emerging technologies to enhance existing analytical methods. 4) Miniaturization and Automation : Explore opportunities for miniaturization and automation to increase throughput, reduce sample and reagent consumption, and enhance efficiency. Implement automated platforms to streamline method development. 5) Data-Driven Approaches : Utilize data analytics, machine learning, and artificial intelligence to analyze large datasets and develop data-driven approaches for method development. Identify critical quality attributes, process parameters and correlations to optimize method performance. 6) Regulatory Compliance : Ensure compliance with regulatory requirements and support filings applying principles described in recent guidelines for analytical method development (e.g. ICH Q2(R2) and Q14). Stay updated on evolving regulatory expectations e.g. related to validation strategies. 7) Collaboration and Leadership : Collaborate with cross-functional teams, including research, DS & DP process development, quality assurance, and regulatory affairs, to align method development activities with organizational goals and project timelines. Provide technical leadership, guidance, and mentorship to junior team members. What you’ll bring to the role Senior expertise in physicochemical analytical method development Senior expertise in applying QbD principles Expertise in automation and data & digital Sound technical and scientific knowledge of pharmaceutical development, analytical sciences, or equivalent Significant experience in biotechnological CMC development Ability to work in a matrix environment Influencing without authority Desirable requirements University degree (PhD or equivalent is desirable) in life sciences Minimum of 10 years of proven experience in the pharmaceutical industry Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Development Business Unit Pharmaceuticals Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Apply to Job(link is external) Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID REQ-10003043 Apr 25, 2024 Switzerland Summary The department of Pharmacokinetic Sciences at Novartis will have an internship position available in Basel. Timing: asap Duration: 3 months #on site About the Role Major accountabilities: This internship will focus to work on a discovery pharmacokinetic screening project using a new established hMice model in collaboration with a non-profit organization outside of Novartis (in life part will be outsourced) Work on your own Pharmacokinetic evaluation and modeling project under the guidance of senior-level quantitative scientist Analyze data from various sources (e.g., animal studies) Attend seminars and other activities to enhance the understanding of the drug development process Present your project results to quantitative scientists and other stakeholders This internship will provide motivated students with exposure to the pharmaceutical industry, and with the opportunity to work in an exciting, multi-disciplinary and multi-cultural environment with senior-level scientists Minimum Requirements: Current enrolled in Master or PhD studies in Pharmacokinetic or Mathematics/Statistics, Physics, Bioinformatics, Biomedical Sciences or Pharmaceutical Sciences/Pharmacy Good theoretical knowledge in antibody pharmacokinetics as well as PK analysis (e.g. NCA, compartmental modelling) and data analysis understanding of pharmacokinetics and predictive PK-PD modeling proficiency with modelling and simulation software (NONMEM/Monolix, MatLab, R, WinNonLin/Phoenix Experience with data sciences (mathematical, biostastatistical data analysis) proficiency in English as well as strong problem-solving skills Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Job Type Full time Employment Type Early Talent (Fixed Term) Shift Work No Apply to Job(link is external)

Job ID 391012BR Apr 29, 2024 Switzerland Summary Job Description Summary 10 ! days - that is how long we in Cell & Gene Therapy treat a patient’s T-cells, before returning them with the potential to save a patient’s life. This is a unique and novel personalized treatment where we work with the patient’s own cells during our production process. Not only are re imagining medicine but we are also impacting on, saving and improving quality of life. As a Cell Processing Specialist you will play an important role in this process by being responsible for operations on Day 0, cell washing and harvest processing and for verifying cell processing associates on intermediate processing days of patient derived clinical and commercial cellular immunotherapy products. You will also managed formulation and verification of all media lots. Due to the nature of the starting material (patient cells) this role requires high level of proficiency and ownership of the process and media formulation. About the Role Major accountabilities: Ownership for the processing of the assigned patient starting material in the clean room environment. Ability to gown aseptically and work in a clean room environment (ISO 8, 7 and ISO 5) areas for extended periods of time. Day 0, cell washing and Harvest processing with the ability to work with automated equipment such as the CS5 and Sepax Verification of intermediate process days which include expertise with the wave bioreactor, NC-200 and in process environmental monitoring Maintains and prepares equipment/environment for use Proficient in the use of production related IT systems such as SAP, LIMS and MES Documents all steps in the assigned Batch record in line with GMP requirements Conduct all necessary processing/verification steps for the assigned lot with highest skill level of aseptic technique Nice to have Requirements: •1-2 years experience in cGMP or academic or lab setting with aseptic or cell culture experience • Apprenticeship or Bachelor's Degree in relevant Engineering or Scientific discipline (e.g. Biology or Laboratory Assistant) • Ability to perform complex calculations and an understanding of scientific notations Must have Language: • Fluent in writing and speaking in English You’ll receive: Breakdown of benefits received in this role. Include flexible working, learning and development opportunities as well. Why Novartis? 766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! Commitment to Diversity & Inclusion Novartis is committed to building an outstanding, inclusive work environment and diverse team's representative of the patients and communities we serve. Accessibility and accommodation Novartis group is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/en_US/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Operations Business Unit Pharmaceuticals Location Switzerland Site Stein Aargau Company / Legal Entity C046 (FCRS = CH028) Novartis Pharma Stein AG Functional Area Technical Operations Job Type Full time Employment Type Temporary (Fixed Term) Shift Work No Apply to Job(link is external) Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID REQ-10004917 May 02, 2024 Switzerland Summary Every year, we are producing 60 million pre-filled syringes, vials and ampoules at our Steriles Large Molecules plant in Stein and deliver the medicines to more than 150 countries. In our Quality Assurance (QA) Operations, Assembly and Packaging team, we are currently looking for a Postgraduate to join us for 6 months and support us in the quality of innovative, biotechnological products in one of Novartis' most important production plants. About the Role Preferred start date: as soon as possible Duration: 6 months Fluent German skills required Your responsibilities will include: Correct, efficient and timely execution of Batch Record Review of assembled and packaged products in the electronic system PAS-X. Control of finished product samples in accordance with cGMP requirements incl. active deadline monitoring. Clarification of complaints in connection with batch documentation and finished product samples in cooperation with production as well as triggering of internal complaints. Regulatory compliance check in the regulatory data base Dragon. Review and approval of parametric batch records (bill of materials). Active participation in the achievement of product delivery targets (On Time Batch Approval, Supply Delivery Dates, Throughput time). QA Oversight on shopfloor of Assembly and Packaging Activities (assembly and packaging production lines). What you'll bring to the role: Essential requirements: Education: Bachelor or Master Degree in natural sciences or pharmacy (completed within the past ca. 12 months); no PhD graduates Languages: German: fluent (oral / written); English: very good understanding Experience/Professional requirements: not necessarily required but insight into the packaging of medicines in the pharmaceutical industry is an advantage Desirable requirements: Ability to work in a team and flexibility Open communication and engagement Knowledge of Good Manufacturing Practice (GMP) Knowledge of MS office and SAP Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com, and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Operations Business Unit Pharmaceuticals Location Switzerland Site Stein Aargau Company / Legal Entity C046 (FCRS = CH028) Novartis Pharma Stein AG Job Type Full time Employment Type Early Talent (Fixed Term) Shift Work No Apply to Job(link is external)

Job ID 394897BR Apr 11, 2024 Switzerland About the Role Wir suchen einen QC Specialist I in unserem Laboratory Support & New Technologies (LSNT) Team. Das LSNT Team ist ein zentralisiertes Team innerhalb der Quality Control Organisation Stein LM, welches die Standardisierung und Harmonisierung über alle QC / AS&T Labore und darüber hinaus ermöglicht. Das Team zeichnet sich durch eine grosse Diversität aus und liefert einen wertvollen Beitrag bei laborübergreifenden Digitalisierungs- und Automatisierungsprojekten. In der Rolle als QC Specialist I betreust du die periodischen Re-Qualifizierungen, Kalibrierungen und Wartungen von unterschiedlichen Laborgeräten (u.a. HPLC, CE, Waagen). Du unterstützt zudem qualifizierungsrelevante Aktivitäten, wie bspw. die Re-Evaluierung von Kategorie C Geräten, Durchführung von User Reviews oder technischen Audit Trail Reviews. Desweiteren unterstützt du das Labor bei Geräteproblemen und führst technische Abweichungen eigenständig durch. Die Position zeichnet sich durch ein vielfältiges Aufgabenfeld aus und ermöglicht es dir, sowohl technische als auch prozessbezogene Aspekte der Qualitätskontrolle zu betreuen. In deiner Funktion arbeitest du eng mit den Laboren zusammen und trägst massgeblich zur weiteren Harmonisierung der physisch / chemischen Labore bei Stein Steriles bei. Key Responsibilities: Betreuung und Durchführung von periodischen Re-Qualifizierungen, Kalibrierungen und Wartungen von Laborgeräten in einem GxP-regulierten Umfeld. Unterstützung qualifizierungsrelevanter Aktivitäten: Re-Evaluierung von Kategorie C Geräten, User Reviews und technische Audit Trails Reviews. Unterstützung bei Geräteproblemen und technischen Abweichungen. Durchführung von Änderungskontrollen und Qualifizierungen von Kategorie B Geräten. Diversity & Inclusion / EEO We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Role Requirements Fundierte technische und wissenschaftliche Kenntnisse im Bereich der pharmazeutischen/chemischen Analytik/QC/Äquivalent . Arbeitserfahrung in einer Laborumgebung in der pharmazeutischen Industrie. Fliessend Deutsch, Englischkenntnisse Industrie GxP Standards und Prozesse Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Operations Business Unit QUALITY Location Switzerland Site Stein (Säckingen) Company / Legal Entity Novartis Pharma AG Functional Area Quality Job Type Full Time Employment Type Regular Shift Work No Apply to Job(link is external)Access Job Account(link is external)

Job ID REQ-10002287 May 02, 2024 Switzerland Summary > 150! That’s how many countries we deliver our ampules, pre-filled syringes, vials and auto injectors to. Take part in this achievement by joining our manufacturing teams at Novartis Stein. You will support our Manufacturing unit where sterile products are assembled and packaged. After familiarization with our procedures and processes you provide front line technical and scientific support for process-specific issues to ensure execution of processes on-time and in compliance to Good Manufacturing Practice. About the Role Preferred start date: as soon as possible Duration: 1 year Fluent German skills required Major accountabilities: Contact person for products and process problems that arise during the ongoing process Collaboration in the preparation of Standard Operational Procedures for routine processes and inputs for electronic master batch record documentation, Lead thorough Root Cause Investigation Process using investigation tools and methodology Application of deviation, complaints, and the implementation of effective corrective actions Team player with strong team spirit Key performance indicators: Compliance/Quality related KPI's Customer Complaints Batch Success Rate Work Experience: work experience in a GMP environment desirable. Skills: Master degree in Pharmacy , Pharmaceutical Technology, Chemistry or equivalent , also Postgraduate with 1-2 years experience desirable Languages : Proficient in German and advanced English required Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you. ​ Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com, and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Division Operations Business Unit Pharmaceuticals Location Switzerland Site Stein Aargau Company / Legal Entity C046 (FCRS = CH028) Novartis Pharma Stein AG Job Type Full time Employment Type Praktikant*in/Student*in (Befristet) Shift Work No Apply to Job(link is external)