Novartis AG

Summary As a Product Manager of the “Target Discovery & Annotations” product, you co-lead, together with a Product Operations Manager and a Technical Lead, a matrix team which supports Data Scientists in identifying new biological targets using novel AI Target Discovery approaches. You develop and evolve a holistic vision, strategy, and roadmap for capturing and prioritizing biological targets, and make sure to establish this data product in the entire end to end data pipeline across the informatics platform and application portfolio. About the Role Major Accountabilities & Key Activities: You combine your knowledge of AI, drug discovery data, and product management with your matrix leadership skills to co-lead a team consisting of operational, technical, and scientific members and to manage a high-impact and globally deployed product consisting of target capturing and target prioritization apps, as well as a hub for accessing target-relevant data. You ensure that these applications are aligned to a capability-based and intentional product architecture and continuously increase their value to deliver significant impact to drug discovery in line with the strategic mandates of the Research Workflows Product Line. Specifically: You provide strategic context to the product team, facilitate prioritization, and practice good team-based decision-making while taking smart risks. You define, communicate and measure success criteria together with internal and business stakeholders, and work closely together to ensure that the product provides the required values to BR’s drug discovery You shape your teams’ processes for success and cultivate a learning environment. You support your team members in challenging situations and act as a mentor for more junior associates. You ensure adherence to security, quality, and regulatory standards and policies, including GxP compliance if applicable. In addition, You help create a strong data architecture and data platform around biological targets. You productionize different AI initiatives around target identification into your product together with our data science community Required Skills & Experience: You are a quick learner and enjoy rapidly acquiring new expertise and establishing new connections and relationships. You are passionate about and experienced in product management in scientific environments and have an intrinsic drive to improve the quality, speed, and impact of scientific research by providing exceptional software products. In addition, you bring many of the following expertise and capabilities, and the drive to grow into the rest: Lead effectively in a co-leadership model inside of a matrix organization. Domain expertise in applied AI technology and management of complex drug discovery data across an entire application portfolio Experience with early drug discovery processes and data, ideally in the domain of biological target identification and target prioritization Excellent communication skills, through writing and speaking. Manage complex and highly interconnected activities with using professional project management skills Creativity in identifying, encouraging, and accelerating innovative solutions. Foster change, manage conflict, and create alignment through direct and indirect influence. Having a clear and visible set of values and acting with integrity. Expand into different areas based on changing scientific and team needs. Language Requirements: English (fluent) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10064054 Oct 15, 2025 Switzerland Summary Oversee the execution and delivery of a portfolio of GCO supported clinical studies for Novartis, of diverse complexities and priorities, in accordance with the Clinical Development Plan (CDP) and Operational Execution Plan (OEP). The assigned portfolio is a set a clinical trials of similar types defining a Study Leadership community. Provide developmental support and guidance to Study Leaders within the community in navigating stakeholders and operational aspects of clinical trials in accordance with Standard Operating Procedures (SOPs), Good Clinical Practices (GCP), and specific country regulations. This covers all operational aspects of a clinical trial. This is a hybrid position based in Basel, Switzerland offices. About the Role Key responsibilities: Leader of a Study Leadership community. This includes people management responsibility within the Study Leadership organization Promotes operational excellence and knowledge sharing across studies. Fosters an empowered, psychologically safe organization that can navigate a matrix environment, learns, and adjusts quickly to changing conditions and business needs. Oversees people allocation (resource management) within assigned community. Oversees the execution and delivery of a portfolio of GCO supported clinical studies for Novartis of diverse complexities and priorities within the assigned community. Leads independently the Clinical Trial Team (CTT) together with the CSL in collaboration with the Clinical Operations Program Head (COPH), delivery of multiple complex global studies and promotes learning, sharing, consistent performance, and operational excellence through an agile mindset, agile principles, and a team of team-s model. Acts as the CTT product co-owner with duties and responsibilities for delivery of the operational strategy per established ways of working. Guides planning and decision making at the study level and delivers assigned clinical study/studies per the Operational Execution Plan (OEP) and clinical study protocol. Fosters an agile culture within assigned studies to achieve sprint goals and cycles, maximizing collaboration and minimizing dependencies in order to achieve long-term business impact. Essential requirements: Bachelor-s degree in life sciences/healthcare (or clinically relevant degree) is required. Advanced degree is strongly preferred. Fluent in English - oral and written 8 years of recent involvement in clinical research or drug development in an academic or industry environment spanning clinical activities in Phases I through IV studies of medium to highly complexity 5 years of recent contribution to and accomplishment in all aspects of conducting clinical studies of medium to highly complexity and of high priority for Novartis (e.g., planning, executing, reporting, and publishing) in a global/matrix environment in pharmaceutical industry or a contract research organization, including expert knowledge of international standards (GCP/ICH), health authorities (FDA/EMA), local/National Health Authorities regulations 5 years recent people management in a complex matrix environment. Experience in managing people globally strongly preferred Management of virtual teams. Proven ability and strong experience leading teams and building capabilities Experience in developing effective working relationships with internal and external stakeholders Excellent communicator and presenter (oral and written); ability to communicate at all levels Why Novartis? Our purpose is to reimagine medicine to improve and extend people-s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You-ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams- representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary Accountable for all country clinical/medical aspects associated with programs/trials by providing clinical strategic and tactical leadership Gathers, informs, and acts on clinical/medical/scientific insights for clinical trial concept sheets/protocols, Informed Consent Forms (ICFs) and other relevant clinical documents to optimize clinical trial implementation. Drives the identification and involvement of qualified investigators with greatest recruitment potential, identifies clinical recruitment hurdles and drives clinical recruitment activities to overcome these hurdles. Accountable for adherence to safety standards and clinical data quality in the country by providing general clinical/medical support for trial related safety findings. In close collaboration with other line functions (e.g., clinical trial operations, Medical Affairs and Patient Engagement) actively contributes to successful allocation, fast clinical trial start-up, timely recruitment, early identification of potential delays, and development and implementation of mitigation plans. About the Role Provides Clinical Development and indication expertise specific to Country, and together with the clinical trial operations team, drives the execution of clinical trials with high quality and within planned time- lines: Validates study designs, is accountable for, and makes the final decision on the clinical/medical trial and program feasibility of implementing a clinical trial protocol based on medical/clinical practice and analysis of the competitive environment in the country. Provides clinical/medical expertise to clinical trial operations team members and clinical trial sites for Institutional Review Boards (IRB)/ Ethics Committee (EC) interactions. Decides on site/Country-specific scientific/clinical/medical content of the Informed Consent Form (ICF) as needed and ensures appropriateness of patient suitable language. Provides scientific/clinical/medical expertise during interactions with Country external Experts (e.g., Regulatory Authorities, Medical Experts, Advisory Boards, Patient Advocacy Groups, etc.). Develops clinical/medical trial plans taking the broader ecosystem into account for assigned pro- grams/trials to ensure successful trial implementation, which includes: Provides robust indication, compound, and protocol training: Leverages innovation in clinical trial planning and decides on clinical/medical recruitment strategy and implementation based upon physician interviews, analysis of competitive trials, and patient engagement. Gathers, informs, and acts on insights from clinical trial Investigators/site staff, Medical Experts, patients, and payers, with internal Stakeholders at the Country level with the goal to optimize clinical trial implementation. Supports planning, implementation, and follow-up of scientific/clinical/medical components of Regulatory Authority inspections and internal audits. Reviews and resolves Country trial-related scientific/clinical/medical issues/questions. If necessary, initiates the discussion with the Global Clinical Development team. Accountable for adherence to safety standards, clinical data quality for the Country and pro- vides general scientific/clinical/medical support for safety issues: Supports the Global Clinical Development team as needed to address/clarify clinical/medical Protocol Deviations through follow-up with clinical trial sites. May support innovative study designs by identifying and conducting quality assessments of Country datasets (e.g., Registries, Electronic Health Records, Payer data, Real World Data, etc.). Role Requirements Education & Experience MD/DO or equivalent, with training in cardiology preferred. Knowledge and clinical training in siRNA desirable Protocol Execution : Demonstrates a knowledge of how to adequately review and read a protocol to understand specifics of study design and answer questions regarding the trial. Applies a detailed understanding of the drug in question to provide medical context as it relates to disease processes, populations, and standards of care. Ability to assess the feasibility of implementing the protocol based on Country medical practice and sound understanding of the overall Clinical Development Plan. Demonstrates a high level of understanding of the protocol to train others, including site personnel. Demonstrates an understanding of the protocol to evaluate compliance on the part of the Investigator/site staff/study participant and any patient safety issues. Demonstrates an understanding of Regulatory requirements and internal policies, procedures, and guidelines pertaining to clinical trials. Demonstrates current knowledge of relevant Country regulations and compliance requirements and communicates to Global teams as required.​Demonstrates knowledge of applicable SOPs, policies, procedures, and guidance documents. Expertise to represent the company as safety expert for clinical trials to external Regulatory and compliance bodies such as Regulatory Authorities, Health Boards, and REB/EC. Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. R ead our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland #onsite Role Purpose: Join our team in Pharmaceutical & Analytical Development (PHAD) and be a part of cutting-edge parenteral drug product development. Contribute to the advancement of novel technology platforms such as Oligonucleotides and Radioligand Therapies (RLT), and work on the Novartis main Campus in Basel. This is your chance to make a significant impact in the biopharmaceutical field and be at the forefront of bringing life-changing medicines to patients worldwide. The PHAD specialty Unit is seeking an experienced Formulation Drug Product Project Leader (FPL) to lead drug product formulation and manufacturing process development. Apply now and be a part of a team that is revolutionizing drug product development. About the Role Major accountabilities: Be accountable for all formulation and manufacturing process deliverables including scientific documentation, design of experiments of parenteral products, batch records, deviations, change controls, CAPAs, tech transfer, and reports. Drive DP development, manufacturing process transfers and supply activities with scientific and technological excellence Work closely with cross functional teams both internal and external to provide technical input for the development and manufacturing process (including CRO and CMOs). Provide technical support to compile technical regulatory documentation and responses to regulatory agencies as needed. Assist with writing and reviewing of CMC documentation associated with project or manufacturing changes. Key Skills Formulation Expertise: Experience developing injectable drugs, including solutions, suspensions, and aseptic formulations. Knowledge of RNA-based therapies (e.g., siRNA, mRNA) and drug delivery systems like pre-filled syringes or vials. Process Development : Skills in designing manufacturing processes and transferring them to production environments. Familiarity with aseptic drug manufacturing and methods like QbD. Lyophilization Development : Experience in developing, optimizing and transferring freeze-dried products, including thermal analysis (DSC, FDM, XPRD), thorough understanding of cycle design and development (including model-assisted approaches), and scale-up from lab to pilot/commercial scale. Regulatory Knowledge: Understanding of GMP and preparing technical documentation for regulatory submissions. Analytical Thinking: Designing experiments (e.g., DoE) and analyzing data to improve formulations and manufacturing processes. Collaboration & Communication: Strong teamwork skills for working with internal teams and external partners (e.g., CROs/CMOs). Clear communication and ability to write reports, technical documents, and regulatory responses. Problem-Solving: Ability to handle deviations, implement corrective actions, and improve manufacturing processes. Innovation: Interest in advancing RNA drug delivery platforms and contributing new ideas to the field. Preferred Technical Experience Working knowledge of oligonucleotide-based therapies (e.g., ADCs, proteins, RNA-based drugs). Familiarity with process development for clinical-grade parenteral drug products. Proven experience in related fields such as pharmaceuticals, biotechnological product development, and advanced drug delivery platforms. Required Qualifications: Ph.D., Master’s or Bachelor’s Degree in Chemistry or related disciplines: With 2+ years (Ph.D.), 5+ years (Master’s), or 8+ years (Bachelor’s) biopharmaceutical experience. Proven expertise in formulation and manufacturing process development for parenteral and aseptic products, including lyophilized dosage forms. Demonstrated capability in lyo cycle development and optimization. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Ulcerative colitis and Crohn's disease, along with other gastrointestinal ailments, represent a diverse array of conditions impacting millions globally. These afflictions have significant unmet medical needs and often lead to a diminished quality of life. Novartis stands at the forefront of pharmaceutical innovation in immunology, leveraging advanced scientific research to develop transformative treatments that enhance patients' lives worldwide. We are seeking a Medical Director or Executive Director of Gastrointestinal (GI) Immunology in Translational Medicine Immunology. Join us in this endeavor! You will provide medical and scientific leadership and expertise in a role that significantly impacts the drug development pipeline. 1. Drive success of early global programs, develop and implement strategies to achieve Transition Decision Point (TDP) 2. Drive success of late global programs by developing and implementing strategies, which lead to clinical pharmacology and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling. 3. Support Translational Research in developing new indications, endpoints and biomarkers, using in vitro, in vivo, or in silico methods. 4. Provide scientific expert assessments and support for in-licensing opportunities, including due diligences. About the Role Major Accountabilities Early clinical projects (Phase I / II, “Discovery”): Develop, in collaboration with TM TA Head and work with teams to carry out, strategies for the Translational Medicine component of drug development projects from Research to TDP in single or multiple indications, including post-indication expansion projects. Lead global project teams through phase I/IIa to drive implementation of the development strategy. Convene relevant (internal and external) experts to consider the proposed approach to reach TDP; present plans for approval at relevant decision boards. Be responsible for clinical portions of the Integrated Development Plan (IDP, including the Clinical Development Plan and Clinical Profiling Plan) Evaluate clinical centers and foster communication with crucial collaborating investigators, regulatory authorities, and other stakeholders. Late-stage clinical projects (post-TDP, “Profiling”): In collaboration with TM TA Head or Translational Medicine Profiling Head: Act as a key leader in developing the Ph2-3 and post-approval profiling strategy for drug programs, representing TMDP on Global Project Team (GPT) along with other TM line functions. Provide support for dose selection, study design and other clinical pharmacology matters throughout the development cycle. Oversee conduct and interpretation of studies prioritized by the to support the pivotal trials, such as special populations, drug-drug interactions, mechanism of action assessments, Pediatric Investigational Plan, etc. Drive analysis of studies and presents results to relevant decision boards. Communicate clinical team matters to GPTs and relevant BR and Development boards [and other Novartis Boards] Evaluate clinical centers and foster communication with crucial collaborating investigators, regulatory authorities, and other stakeholders. Be responsible for writing TM portion of documents needed for regulatory submission through drug registration (including advisory committee and scientific advice group meetings) Translational Research (TR; indication seeking, endpoint and biomarker development): In collaboration with TM TA Head, BR Research scientists, other TM line functions (BMD, CS&I, PCS, PKS), develop strategies to identify initial or expansion (PIE) indications, and to obtain sufficient evidence to fund these ideas. In collaboration with research scientists, identify, develop, and implement strategy for preclinical support of clinical program-related scientific objectives. This includes assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications, and other relevant activities. This may include methodology studies to identify and validate novel endpoints for early decision making in Phase IIa studies. Be accountable for compound-related biomarker strategies; works closely with Biomarker Expert in implementation. Business Development and Licensing (BD&L; in-licensing and outlicensing compounds): Participate on BD&L teams as the TM representative. In collaboration with BD&L team, evaluate the risks and benefits of potential in-licensing opportunities, identifying the strengths and weaknesses of external programs in terms of TM’s scope of responsibility. Participate in teams carrying out out-licensing of BR programs, as subject matter expert for the disease indication, molecule, and clinical trial experience. Leadership: Lead study-specific teams/ clinical trial teams in partnership with other line functions. Lead BR-sub-team(s) on Global Project Teams for late-phase programs Collaborate closely with other TM (especially CS&I) and non-TM (especially Project Man- agement) line functions to ensure operational excellence, continued urgency, and close attention to timelines, costs, and subject burden in balance with high scientific stand- ards and innovation. Key Performance Indicators Delivery of proposed Development Candidate ((B)DC) and Integrated Development Plan Approval (IDPA) milestones, and results driving decision-making for/against transition into later phase development (TDP), according to defined timelines. Delivery of Clinical pharmacology and profiling strategy including execution of studies according to timelines to support regulatory submissions and approvals. Delivery of TR plans, whether in vitro, in vivo, or in silico, to drive program strategy and clinical trial efficiency. Team leadership skills that create high performing teams and drive efficient conduct of innovative, interpretable clinical results and a focus on operational excellence at all levels. Strong adherence to and modeling of Novartis values and behaviors. Impact of this role? Design and implementation of early Integrated Develop- ment Plan (IDP) and design and implementation of studies according to the IDP, enabling efficient and rational decision-making, high probability of fast drug registration, favorable drug label and high competitiveness of compounds. This role has a key impact on the entire Novartis pipeline, transitioning programs from preclinical through early clinical and ultimately to full development via the TDP mechanism, and driving the program after TDP by delivering key Profiling data to support regulatory submissions. Recognized Expert in field, drives project team clinical strategy. Works globally across Novartis. Role Requirements : Education Doctoral degree, MD required in most cases. PhD or relevant scientific experience with academic track record preferred Demonstrated excellence and clinical expertise in relevant medical subspecialty. Experience/Professional Requirement: At least 5 years’ experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience. Recognized medical expertise, as evidenced by publication of significant contributions to a field over time. Excellent written and oral communication/presentation skills. Independence: Able to work independently as outlined above, commensurate with level of role. Innovation: Seeks out new clinical discovery opportunities and approaches to reach TDP. Demonstrated passion for science. Recognized expert in field, driving success for individual studies and projects; respected by colleagues across R&D, Development, and externally. Languages: Fluent English (oral and written). ABOUT TRANSLATIONAL MEDICINE: Translational Medicine is a global group of scientists and Physicians working at the pre-clinical and early clinical stage of drug discovery. Our Physician-Scientist Discovery & Profiling group drives innovative and cutting–edge science from Discovery to the market through the selection, profiling and effective global development of successful medicines. The group closes the gap between preclinical research and clinical development and integrates clinical science into the discovery and preclinical development phase. Our Translational Medicine concepts are driven by medical needs of the patient and the concept of personalized medicine, tailoring the drug, its dose and dosing regimen in such way to the patient that the clinical response is optimal in terms of efficacy and safety. We focus from identification of drug targets (molecular pathways relevant to disease) up to the completion of Proof of Concept (Phase IIa studies). Our Translational Medicine Experts are part of preclinical project teams in all drug discovery phases and help design the pathway for First in Human studies (healthy volunteer) that bridge to studies in the patient population. They have the comprehensive responsibility for designing and executing the early clinical drug development phase together with a project team from researcher, biomarkers, biostatistics, modeling and simulation, toxicology, technical experts and the clinical trial teams. Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Full time, onsite, #LI-Onsite We are seeking a highly motivated scientist to advance our mission to deliver transformative new therapies for patients with chronic diseases, with a special emphasis on liver diseases, in the Disease Area x (DAx) at the Novartis Biomedical Research (BR) facility located in Basel, Switzerland. In this position, you will identify and lead novel innovative therapeutic approaches to treat chronic diseases, such as liver diseases, ranging from target identification and validation to drug discovery and identification of candidate molecules towards clinical evaluation. A deep understanding of liver physiology and pathology is strongly desirable. You should possess advanced proficiency in cutting-edge molecular biology techniques, have expert knowledge of cellular tissue models and profiling technologies, and be adept at using data science tools to analyze complex datasets. In that role, you will be leading a team of experienced scientists and contribute to the strategic development of the liver therapeutic area and beyond. About the Role A deep understanding of liver physiology and pathology is strongly desirable. You should possess advanced proficiency in cutting-edge molecular biology techniques, have expert knowledge of cellular tissue models and profiling technologies, and be adept at using data science tools to analyze complex datasets. In this role, you will be leading a team of experienced scientists and contribute to the strategic development of the liver therapeutic area and beyond. Key responsibilities: Lead a group of scientists focused on preclinical activities related to the identification and validation of targets and drug candidate molecules for chronic illnesses, with a particular emphasis on liver diseases. Apply innovative in vitro/ex vivo models, which reflect human disease conditions, to identify drug candidates. Translate therapeutic concepts from preclinical models to patients and vice versa , including cutting-edge experimental approaches and application of data science tools. Strongly contribute and influence the strategic direction of liver research in DAx, stay up-to-day with latest developments in the field of liver diseases. Shape, mentor, and lead a high-performing team of scientists by fostering a collaborative environment and developing skills of team members. Navigate effectively in a matrix-based, cross-functional environment, collaborating across departments within Novartis Biomedical Research and beyond. Maintain a strong external network with academic institutions and manage external collaborations. Essential requirements: PhD/Postdoc in life science, such as cell or molecular biology or physiology. A minimum of 5 years in drug discovery for chronic diseases in an industrial setting with demonstrated expertise ranging from target identification toward clinical application. Possess an in-depth molecular understanding of physiology and disease pathophysiology, such as for liver diseases, and have expert knowledge of cell-based methods (primary cells, organotypic cultures, explants) to mimic disease conditions in vitro/ex vivo . Is highly proficient in state-of-the-art molecular, cellular and biochemical assay and profiling technologies, including – but not limited to – single-cell transcriptomics techniques. A deep understanding of data science and application of data science tools to evaluate complex datasets is highly desired. Proven leadership skills in managing and guiding teams effectively, including setting and evaluation of objectives, and advancing the development of people. Demonstrated ability to work independently and as part of a collaborative, interdisciplinary team of biologists, computational scientists, and translational research/medical scientists. Strong written and verbal communication skills, organizational skills, and excellent attention to detail. *Restrictions on flexible working and reduced working time may apply and can be discussed at interview stage if required Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Oversee the execution and delivery of a portfolio of GCO supported clinical studies for Novartis, of diverse complexities and priorities, in accordance with the Clinical Development Plan (CDP) and Operational Execution Plan (OEP). The assigned portfolio is a set a clinical trials of similar types defining a Study Leadership community. Provide developmental support and guidance to Study Leaders within the community in navigating stakeholders and operational aspects of clinical trials in accordance with Standard Operating Procedures (SOPs), Good Clinical Practices (GCP), and specific country regulations. This covers all operational aspects of a clinical trial. This is a hybrid position based in Basel, Switzerland offices. About the Role Key responsibilities: Leader of a Study Leadership community. This includes people management responsibility within the Study Leadership organization Promotes operational excellence and knowledge sharing across studies. Fosters an empowered, psychologically safe organization that can navigate a matrix environment, learns, and adjusts quickly to changing conditions and business needs. Oversees people allocation (resource management) within assigned community. Oversees the execution and delivery of a portfolio of GCO supported clinical studies for Novartis of diverse complexities and priorities within the assigned community. Leads independently the Clinical Trial Team (CTT) together with the CSL in collaboration with the Clinical Operations Program Head (COPH), delivery of multiple complex global studies and promotes learning, sharing, consistent performance, and operational excellence through an agile mindset, agile principles, and a team of team’s model. Acts as the CTT product co-owner with duties and responsibilities for delivery of the operational strategy per established ways of working. Guides planning and decision making at the study level and delivers assigned clinical study/studies per the Operational Execution Plan (OEP) and clinical study protocol. Fosters an agile culture within assigned studies to achieve sprint goals and cycles, maximizing collaboration and minimizing dependencies in order to achieve long-term business impact. Essential requirements: Bachelor’s degree in life sciences/healthcare (or clinically relevant degree) is required. Advanced degree is strongly preferred. Fluent in English - oral and written 8 years of recent involvement in clinical research or drug development in an academic or industry environment spanning clinical activities in Phases I through IV studies of medium to highly complexity 5 years of recent contribution to and accomplishment in all aspects of conducting clinical studies of medium to highly complexity and of high priority for Novartis (e.g., planning, executing, reporting, and publishing) in a global/matrix environment in pharmaceutical industry or a contract research organization, including expert knowledge of international standards (GCP/ICH), health authorities (FDA/EMA), local/National Health Authorities regulations 5 years recent people management in a complex matrix environment. Experience in managing people globally strongly preferred Management of virtual teams. Proven ability and strong experience leading teams and building capabilities Experience in developing effective working relationships with internal and external stakeholders Excellent communicator and presenter (oral and written); ability to communicate at all levels Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10059981 Sep 09, 2025 Switzerland Summary Accountable for all country clinical/medical aspects associated with programs/trials by providing clinical strategic and tactical leadership Gathers, informs, and acts on clinical/medical/scientific insights for clinical trial concept sheets/protocols, Informed Consent Forms (ICFs) and other relevant clinical documents to optimize clinical trial implementation. Drives the identification and involvement of qualified investigators with greatest recruitment potential, identifies clinical recruitment hurdles and drives clinical recruitment activities to overcome these hurdles. Accountable for adherence to safety standards and clinical data quality in the country by providing general clinical/medical support for trial related safety findings. In close collaboration with other line functions (e.g., clinical trial operations, Medical Affairs and Patient Engagement) actively contributes to successful allocation, fast clinical trial start-up, timely recruitment, early identification of potential delays, and development and implementation of mitigation plans. About the Role Provides Clinical Development and indication expertise specific to Country, and together with the clinical trial operations team, drives the execution of clinical trials with high quality and within planned time- lines: Validates study designs, is accountable for, and makes the final decision on the clinical/medical trial and program feasibility of implementing a clinical trial protocol based on medical/clinical practice and analysis of the competitive environment in the country. Provides clinical/medical expertise to clinical trial operations team members and clinical trial sites for Institutional Review Boards (IRB)/ Ethics Committee (EC) interactions. Decides on site/Country-specific scientific/clinical/medical content of the Informed Consent Form (ICF) as needed and ensures appropriateness of patient suitable language. Provides scientific/clinical/medical expertise during interactions with Country external Experts (e.g., Regulatory Authorities, Medical Experts, Advisory Boards, Patient Advocacy Groups, etc.). Develops clinical/medical trial plans taking the broader ecosystem into account for assigned pro- grams/trials to ensure successful trial implementation, which includes: Provides robust indication, compound, and protocol training: Leverages innovation in clinical trial planning and decides on clinical/medical recruitment strategy and implementation based upon physician interviews, analysis of competitive trials, and patient engagement. Gathers, informs, and acts on insights from clinical trial Investigators/site staff, Medical Experts, patients, and payers, with internal Stakeholders at the Country level with the goal to optimize clinical trial implementation. Supports planning, implementation, and follow-up of scientific/clinical/medical components of Regulatory Authority inspections and internal audits. Reviews and resolves Country trial-related scientific/clinical/medical issues/questions. If necessary, initiates the discussion with the Global Clinical Development team. Accountable for adherence to safety standards, clinical data quality for the Country and pro- vides general scientific/clinical/medical support for safety issues: Supports the Global Clinical Development team as needed to address/clarify clinical/medical Protocol Deviations through follow-up with clinical trial sites. May support innovative study designs by identifying and conducting quality assessments of Country datasets (e.g., Registries, Electronic Health Records, Payer data, Real World Data, etc.). Role Requirements Education & Experience MD/DO or equivalent, with training in cardiology preferred. Knowledge and clinical training in siRNA desirable Protocol Execution : Demonstrates a knowledge of how to adequately review and read a protocol to understand specifics of study design and answer questions regarding the trial. Applies a detailed understanding of the drug in question to provide medical context as it relates to disease processes, populations, and standards of care. Ability to assess the feasibility of implementing the protocol based on Country medical practice and sound understanding of the overall Clinical Development Plan. Demonstrates a high level of understanding of the protocol to train others, including site personnel. Demonstrates an understanding of the protocol to evaluate compliance on the part of the Investigator/site staff/study participant and any patient safety issues. Demonstrates an understanding of Regulatory requirements and internal policies, procedures, and guidelines pertaining to clinical trials. Demonstrates current knowledge of relevant Country regulations and compliance requirements and communicates to Global teams as required.Demonstrates knowledge of applicable SOPs, policies, procedures, and guidance documents. Expertise to represent the company as safety expert for clinical trials to external Regulatory and compliance bodies such as Regulatory Authorities, Health Boards, and REB/EC. Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. *R ead our handbook to learn about all the ways we-ll help you thrive personally and professionally: *Novartis Life Handbook Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Universal Hierarchy Node Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Alternative Location 1 Dublin (NOCC), Ireland Alternative Location 2 London (The Westworks), United Kingdom Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary Novartis is at the forefront of medical research and bringing innovative and life changing medicines to millions of patients. Animal research is key to many of the great medical advances of today and animals play an integral part in the discovery and development of innovative, safe and life-saving medicines for patients. The Basel Head of Animal Welfare and Integrity Assurance (AW&IA) will lead, manage, and evolve the internal animal care and use program oversight for Biomedical Research Basel. About the Role Novartis upholds the highest standards and ethics of Animal Welfare and research, with steadfast commitment to the 3Rs principles (Reduction, refinement, Replacement), as well as introducing further improvements including the ‘4th R’ of Responsibility and our Biomedical Research sites all earning independent, international Gold Standard accreditation from the Association for Assessment and Accreditation of Laboratory Care (AAALAC). The Head of Animal Welfare and Integrity Assurance will ensure that all work involving research animals at Biomedical Research Basel is in compliance with Swiss laws and the Novartis Animal Welfare policies and standards. The role will include responsibilities such as liaising on behalf of Novartis Biomedical Research with regulatory authorities, accreditation bodies, and external groups and championing animal welfare and the 3Rs, as well as advocate for the critical role of animals in biomedical research. Your Responsibilities will include but not be restricted to: Lead internal oversight of the Biomedical Research Basel animal care and use program, including acting as site’s Lead Animal Welfare Officer and key contact for all in vivo users, regulators, and accreditation bodies. Direct Biomedical Research Basel AW&IA activities as Site Head to achieve efficient, consistent, compliant, and continuous improvement of animal care and use oversight operations, including: management and support of the license review and animal number reporting process post-approval monitoring program semi-annual inspections and program reviews investigation of reported animal welfare concerns/non-compliances ensure appropriate management of the Animal Welfare Body meetings as chair and all related preparation, facilitation, administration and follow-up actions serve as key contact to in vivo leadership including to the Institutional Official, Basel Pharmacology Council, and Basel Leadership Team support the development of the new animal management system Serve as named main point of contact for regulatory and accreditation needs, including both announced and unannounced inspections, communication with the Cantonal and Federal veterinary authorities, for documentation/information (e.g. lead AAALAC program description and site visits), and reporting out to agencies on applicable timelines (e.g. annual reports, ad hoc event reporting) Lead and manage direct reports in local AW&IA team, ensuring their development and appropriate time management. Act as a key contributor to the Global AW&IA team representing the Basel site to the Ethical Review Council, Global 3Rs Working Group and Global Risk Review teams Promote the 3Rs via leadership or delegated leadership of the local 3Rs Working Group including promotion of the 3Rs Awards programs and Innovation in 3Rs Granting program Together with colleagues in Public Affairs, promote openness and education about the continued need for and value of animal research through internal and external collaborations and communication, including participation in direct political stakeholder engagement. Minimum Requirements – what you will bring to the role: Education : University degree (PhD, Vet med, Med) in biology, veterinary medicine or medicine. Special knowledge in laboratory animal science and alternative methods. Authority approved study director role in Switzerland Experience in regulatory compliance and working as an Animal Welfare Officer in Switzerland, leading an IACUC or animal welfare body Experience: At least 5 years experiences in animal experimentation and leading and managing personnel in an in-vivo research environment Experienced in leading and managing a team of Direct and indirect Reports in a complex matrixed research and operations pharma industry environment Knowledge in public relations and Professional experience in communicating about and supporting advocacy efforts for the need for animal research to internal and external audiences highly desirable Experience working collaboratively with regulators and accreditation bodies Experience in supporting 3Rs (reduce, refine, replace animal studies) programs Languages: English and German fluent, proficiency in e.g. French would be of advantage. Desirable Continuous improvement skills and experience in using evidence to design and test improvements to programs and processes, including advancing AI and automation in licensing and reporting Experience in assessing animal care and use programmes requiring larger laboratory animal species, including Non-Human Primates (NHP), Pig, and Dog Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary #LI-Hybrid Location: Basel, Switzerland or Dublin, Ireland. Data42 is Novartis’s data and analytics platform, that allows us to integrate different data modalities (discovery, preclinical, clinical, Real World Data (RWD)) at scale to support data-driven decision making across Novartis. We are seeking a Head of Data Engineering and Data Products to join our dynamic and innovative data and analytics team. This pivotal role is responsible for designing, building and maintaining data solutions using Palantir Foundry. In this role you will foster the use of AI/GenAI to advance the speed of high quality data delivery as well as to democratize the access to data and insights across the organization. The Head of Data Engineering and Data Products is a member of the Data42 Leadership team which comprises a Head of Data Science and Innovation, a Head of Platform as well as a Data Governance lead. In addition, this role will collaborate with key stakeholders across the Data and Digital Organization and across Novartis to ensure the rapid delivery of high quality data and data products with a team of ~50 internal and external team members. You will contribute to the overall success of Data42 as a member of the Data42 Leadership Team. This role will report directly to the Global Head of Data42. About the Role Your responsibilities include but are not limited to: Data Engineering Define the vision, lead and continue to develop our cross-functional Data Engineering and Data Products team by staying current with emerging technologies Responsible for architecting, designing, maintaining and optimizing complex data pipelines to support data exploration, operational workflows as well as advanced analytics Ensure best practices for data ingestion, processing, validation, transformation and storage Implement processes that guarantee data quality, integrity, security, compliance, and discoverability across platforms Advance the further use of automation and AI to accelerate the quality, speed and breadth of data delivery Data Products Accountable for designing, building and running scalable data product solutions using agentic workflows on Palantir Foundry to democratize data access with future needs in mind. Establish and action security and compliance policies to safeguard data access and dissemination Collaborate across the Data and Digital Organization as well as across Novartis. Support and ensure the flexible co-ordination of activities to deliver against timelines Delivery and Operations: Define and track key measurements for data systems and product success Oversee the project planning, delivery, and ongoing support for data engineering and product development Drive continuous improvement by monitoring system performance, analyze product data, and respond to feedback Essential Requirements: PhD or master’s degree in computer science or a related discipline with experience in pharma R&D with more than 10-15 yrs of experience in pharma or biotech Experience in data management, data engineering and data modelling, particularly in the design and implementation of efficient and scalable data models across different data domains with Clinical and RWD experience preferred Knowledgeable and experienced in CDISC data models/standards (i.e. SEND, SDTM, ADaM) and RWD data models/standards (i.e. OMOP) Experience with cloud platforms and cloud-based data and AI/ML solutions (Databricks, Snowflake, AWD SageMaker etc…) Strong enterprise mindset strategic thinker with a vision for data-driven decision-making from an end-to-end perspective Proven global cross-functional leadership skills including coaching and talent development, with the ability to influence stakeholders and drive organizational change within complex and ambiguous environments Excellent communication skills with proficiency in English (oral and written) Nice to have: Ideally proficient in Palantir Foundry to integrate, manage and analyze large data-sets Commitment to Diversity & Inclusion: We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Benefits and rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards For Basel, Switzerland: Switzerland Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary #LI-Hybrid Location: Basel, Switzerland Are you ready to shape the future of cardiovascular medicine across international markets? As International Medical Affairs Director – Cardiovascular, you’ll drive innovative strategies that directly impact patient outcomes and healthcare systems. You’ll collaborate with global experts, lead evidence generation, and ensure our medicines reach those who need them most. This is your opportunity to make a meaningful difference—bringing your expertise, vision, and passion to a team that values bold ideas and real-world impact. About the Role Key Responsibilities Experience in the cardiovascular therapeutic area (Atherosclerotic cardiovascular disease (ASCVD), atrial fibrillation (AF), and thrombosis/anticoagulation is preferred) Lead strategic medical affairs programs to support innovative evidence and launch readiness across international markets. Develop and execute integrated evidence plans to maximize value for prioritized cardiovascular portfolio. Partner with country Medical Affairs teams to ensure strong delivery focus on local needs. Advise on evidence generation, medical education, and scientific publication planning for therapeutic areas. Co-own development and implementation of education and communication plans for all brands. Track financials to ensure timely and cost-effective execution of medical activities. Collaborate with Development, Value & Access, and Commercial teams to shape launch portfolio and access strategies. Represent International Medical Affairs with internal and external stakeholders, including regulatory and industry partners. Provide direction for successful reimbursement and market-access strategies. Ensure all medical affairs activities are compliant with company policies and highest medical quality standards. Essential Requirements Medical Doctor (MD) or PhD/PharmD in Health Sciences. Minimum 5 years of experience in the pharmaceutical industry, ideally in Medical Affairs or Clinical Development. Fluent oral and written English; additional relevant languages are an advantage. Proven ability to build credibility and influence across diverse stakeholders in a matrix organization. Demonstrated success in cross-functional and cross-market collaboration. Deep understanding of healthcare systems and key external stakeholders. Strong track record of delivering medical affairs projects on time and with high quality. Experience developing and implementing innovative programs and processes. Desirable Requirements Highly preferred: Above market experience and significant medical affairs pre-launch and launch experience in major markets (such as Germany, China, Japan). Experience in developing and executing “Best in Class” processes at scale. Commitment to Diversity and Inclusion / EEO paragraph: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and Accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary #LI-Onsite We are looking for a dedicated QC Analyst to support Good 'x' Practice (GxP) activities in our quality department. This role involves managing quality systems, implementing operational processes, and ensuring compliance with Novartis quality standards. About the Role Key Responsibilities: Maintain compliance with current Standard Operating Procedures (SOPs), GxP-compliant documentation, and records within the Novartis quality management system. Perform and evaluate analytical tasks in a pharmaceutical laboratory, including working in shifts where necessary. Ensure the integrity of all quality assurance records and data, as applicable, and foster collaboration between your team and other functions and departments. Ensure an appropriate level of education and GxP knowledge. Support quality audits and health authority inspections. Essential Requirements: Experience in quality assurance and analytical skills. Proficiency in analytical technologies (e.g., HPLC, GC, titration). Knowledge in the use of lab-specific software (e.g., Empower, Chromeleon, TiAmo). GMP experience and technological expertise. Willingness to work in shifts. Fluency in German and English. This role is limited to 24 months. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Benefits and Rewards : Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion / EEO: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, be-cause of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) *Disclaimer: Some restrictions on flexible working options may apply and will be discussed during interview if applicable. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Role Purpose: Without safe, easy-to-use, high-quality drug delivery systems our patients could not get their medicines. This is where you come in; the Device Technology Solution Center needs you as Senior Expert Engineering for the development of drug device combination products working alongside our talented, bright and diverse teams. Our Device Technology Solution Center drives the technical development of auto-injectors as well as novel drug delivery principles, e.g. drug delivery to the brain or radioligand therapy. We closely collaborate with project management, human factors engineers, packaging experts, analytical testing, production, external partners, regulatory experts and many more. The aim is to develop and/or integrate innovative drug delivery systems with drug formulation and author state-of-the-art technical documentation for health authorities and production. About the Role Your Responsibilities: Your responsibilities include, but are not limited to: Develop platforms and collaborate with cross-functional teams to deliver safe, user-friendly, and reliable products Lead and support teams in the field of assembly and injection molding for device/part design, equipment and process across from prototyping to commercial scale Create and maintain relevant Design History File (DHF) documents, ensuring high-quality device design and development Contribute to all phases of medical device development: ideation, prototyping, piloting, and manufacturing transfer Ensure components meet quality standards for clinical trials and commercial production Collaborate with external partners, including prototypers, toolmakers, and CMOs Identify root causes of issues, define and implement robust solutions Role Requirements Degree in mechanical engineering or equivalent Preferably 10 years of experience in medical device development Proficient spoken communication and excellent technical writing skills in English Proven experience in production of plastic and metal components Proven experience in assembly of plastic and metal components / sub-assemblies Proven experience in design for manufacturing and design for assembly Good knowledge in key regulations and standards (e.g. ISO 13485, ISO 23908, ISO 11608, ISO 10993, MDR, Design Controls) Ability to interact with cross functional team in matrix organization Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Wir suchen eine/n Chemie- & Pharmatechnolog-in/en (CPT) zur Unterstützung der Abteilung Chemical & Analytical Development (CHAD) als Teil der Abteilung Global Technical R&D (TRD). In dieser Funktion bist du für die effektive Herstellung von Zwischenprodukten und Wirkstoffen gemäss Herstellvorschriften (Plant Master Procedures – PMPs) verantwortlich durch selbstständige Bedienung komplexer Prozessapparate und unter Einhaltung der SOP-, GSU- und anderer Richtlinien. Wir operieren innerhalb des Local Supply Center (LSC) für die klinische Versorgung in der Früh- und Spätphasenentwicklung in verschiedenen Modalitäten (z. B. synthetische Oligonukleotide, Peptidsynthese, klassische organische Chemiepräparate, Herstellung von Biokonjugaten). Wir bieten dir die Möglichkeit in einem dynamischen, agilen Umfeld in spannenden Projekten mit abwechslungsreichen Tätigkeiten sowie Entwicklungsmöglichkeiten zu arbeiten. About the Role Deine Verantwortlichkeiten umfassen eine Vielzahl von Aufgaben, die sicherstellen, dass die Produktionsprozesse reibungslos und effizient ablaufen. Dazu gehören: Zusammenarbeit und Interaktion mit internen Stakeholdern, um Projekte erfolgreich durchzuführen und wichtige Meilensteine sowie Qualitätsstandards einzuhalten. Kommunikation von Problemen an Teams und Linienmanagement. Anwendung gelernter Lektionen und Arbeiten gemäss vorgegebenen Richtlinien, um eine positive Arbeitsethik zu zeigen und andere positiv zu beeinflussen. Vorbereitung von Anlageketten und anderen Produktionsvariablen sowie die selbstständige Bedienung der zugewiesenen Anlagen und Systeme. Durchführung von Abfallentsorgungstätigkeiten gemäss internen und externen Vorschriften. Demontage, Reinigung und Remontage der Prozessanlageketten nach der Produktion. Aufzeichnung aller notwendigen Informationen im Batchprotokoll. Beitrag zur Reinigung und nachhaltigen Unterhalts des Betriebs. Einbringung von Ideen und Lösungsvorschlägen zur Behebung von Anlage- und Prozessfehlern sowie zur Prozess- und Sicherheitsoptimierung über interne Innovationsplatform. Beratung von weniger erfahrenen Prozesstechnikern bei der Bedienung der Anlagen, Prozessplanung, -durchführung und Anlagenreinigung. Durchführung spezieller Tätigkeiten wie analytische Prozessablaufkontrollen oder Wahrnehmung von Verantwortungen gemäss Verantwortlichkeitslisten. Was du mitbringst: Eine Ausbildung in einem logistischen, technischen oder verwandten Geschäftsbereich, idealerweise als Chemie- und Pharmatechnologe EFZ. Praktische Erfahrung in der chemischen oder pharmazeutischen Industrie als Chemie- und Pharmatechnologe EFZ. Vertrautheit mit der Arbeit mit computergestützten Steuerungssystemen sowie den GMP- und GSU-Anforderungen. Bereitschaft, in einem 3-Schicht-Modell und in einem vollständigen Schutzanzug (fremdbelüftet) bzw. in Reinraumbekleidung (bis Reinheitszone C) über längere Zeit zu arbeiten. Sehr gute Deutschkenntnisse in Wort und Schrift sowie Grundkenntnisse in Englisch. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Role Purpose: The Therapeutic Data Strategy Director (TDSD) bridges science and operations by defining how the clinical data strategy is operationalized across the complete data flow within GCO. The TDSD is responsible for ensuring data regulatory compliance, the availability of End-to-End (E2E) standards, that instruments and devices are thoroughly discussed, defined, and finalized prior to the database build and that the operational impact of any new changes are known, , mitigated, and captured in the appropriate knowledge database. In collaboration with the GPT, GCT, and CTT, the TDSD aligns on the fit for purpose data package as part of a program / indication level quality by design to support data strategy needs in the drug development lifecycle of a molecule or across therapeutic area (TA) within an assigned unit in Novartis. This role creates and implements strategies for the end-to-end data product, ensuring application of Novartis clinical data standards and defining the clinical data acquisition and data review, strategy to support the submission of our clinical programs. The TDSD is responsible for ensuring that delivery and timelines are met with quality, whilst ensuring cost efficiencies and stakeholders’ satisfaction. About the Role Creation and Execution of operational data strategy: Collaborate with the Global Program Clinical Head (GPCH) to establish and maintain a data strategy for the clinical data standards of the assigned Therapeutic Area, as well as the design, collection, processing, transformation, of clinical data supporting the needs for reporting and submission. Impact assessment of proposed data collection and analysis Drive capability inputs to data team’s resource algorithm based on future incoming demands Matrix data operations leader who is the single focal point for the sustained industry leading cycle time for data product and ensures compliance with relevant Novartis processes Ensures the provision of resource with the skillset to develop robust & lean E2E specification. Leads the full spectrum of standard development and compliance across their portfolio. Consults to drive quality into the study protocol and operational processes. Driving implementation of a lean global data strategy and define minimum data requirements Ensure the minimum data requirements remain intact and understanding the operational impact e.g., resources, and time of any amendments as well as work with clinical development, analytics and regulatory line functions to understand the scientific, clinical, statistical and regulatory impacts. Support assessment on opportunity to capitalize on non-traditional options (e.g., historical data, synthetic data, cross-sponsor shared control arms, adaptive designs, pragmatic trials, decentralization, etc.). Work with COPH and Vendor Program Strategy Director (VPSD) to define the provision of ancillary data, including vendor capabilities. Author the Operational Data Strategy Section of Operational Execution Plan (OEP) (key customers, dataflow, and targets to generate Data-as-a-Product (DaaP) etc.). Establishes a “performance-oriented culture” that is driven / supported by analysis of real-time activity and quality metrics Contribute to the development of the Data Operations organization. Define/contribute to the development of long term goals and operating policies through his/her leadership role on the management team. As an extended member of the Data Operations Leadership Team support functional excellence for Data Operations by contributing to the definition of the strategic goals and operating policies, and leading/contributing to strategic initiatives in line with the overall Data Operations strategy. Support the BD&L activities from CDO perspective. End-to-End Ownership of the Clinical Data Flow: Ensure that data is collected and reviewed as efficiently as possible, and that extraneous data is not procured. Drives implementation of a lean global data strategy and defines fit for purpose data quality requirements sufficient to support good decision making and meet regulatory requirements. Collaborates cross-functionally to define quality by design review process to ensure fit for purpose data quality sufficient to support good decision making. Accountable for managing operational strategy around data cleaning and data review at portfolio level. Drives standards and processes to facilitate data right the first time. Act as point of escalation for data specific project management issues and for broader data demands (e.g. changing scope, addition of analysis/reporting events). End-to-End Standards Oversight & Lifecycle Management: Responsible for compliance with data requirements and the availability of end-to-end clinical data standards (data collection through analysis) for a program/molecule/indication. Influence and support the design of new clinical data standards as required at the enterprise/ therapeutic area level. Drives identification of needs, adoption and maintenance of data standards. Operational Project Management: Develop, communicate, and drive implementation of a global data operationalization strategy to deliver value-adding data; CDS supports and guides the Data Team (as part of the CTT) in ensuring the overall program /OEP strategy is aligned with execution. Establish key customers of Clinical Data and establish approach for future consumption. Works with the business to ensure adherence to timelines, adoption of the data strategy and delivery of the target data product quality. Accountable for managing the strategy of the data cleaning, review, and data related specifications at portfolio and study level. Ensure high quality, timely and efficient Data Operation deliverables for projects and trials partnering with other Data Operations functions within assigned Development Unit or program. Work alongside the Operational Program Lead and Trial Lead to ensure all data related risks and issues are identified and mitigated. Link between business needs and technical development/deployment and technology usage in data operations. Influencer and interlocutor for adoption and compliance with company efficiency process and objectives within data workflow. Assesses / approves changes that impact the data collection strategy. Education: Minimum: Bachelor’s degree in life sciences, preferably with a statistics module. Desirable: Degree in statistics or mathematics. Experience/Professional requirement : A minimum of 10 years in a R&D regulated environment in a relevant pharmaceutical or health care company. Excellent understanding of end-to-end clinical data processing and the clinical trial operations space. Extensive knowledge and experience in ICH-GCP Process Control or ICH-GCP Quality Assurance systems and Health Authority regulations; Clinical Operations experience in these areas is preferred Demonstrated ability for leading initiatives with cross-functional teams and implementation of recommendations Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10060714 Sep 01, 2025 Switzerland Summary Location: Basel, Switzerland OR Ivrea, Italy Role Purpose: We are looking for experience in the field of the industrialization of Radioisotope production and related technologies, with an emphasis on isotope separation technologies and isotope development supporting our growing portfolio. Our Unit is driving successful execution of a wide range of isotope-related projects. This starts with early strategic and operational discussions on isotope production technologies, assembly of internal teams and execution of desired strategy, up to technical leadership of early process development and the developability assessment of chosen isotope separation technologies. You will be reporting to the Head of the Global Isotope Development Unit. You will be leading an Isotope Project Team consisting of Isotope Project Leads from different scientific areas who act as members of the development project teams by optimally setting up people, assets, and equipment to best serve project needs according to priority and ensure timely delivery of high-quality products and solutions. About the Role Major accountabilities: Work collaboratively with cross-functional and multidisciplinary teams, spanning multiple NVS global sites to discover and develop efficient RLTs. Build and lead internal Project management team of experimental scientists and project leads. Seek technical and operational input from key stakeholders to build the project execution plan. Lead internal project meetings. Collect and interprets data to advance project, adapts strategy, and addresses the right scientific questions. Ensure team discussions and decisions are summarized in minutes. Ensure that key milestones and go / no go criteria are data driven and clearly defined. Own quality of project information and make sure project information is accurate and included in the system(s) in a timely matter. Guide projects with respect to isotope approaches and technologies and leads corresponding efforts. Lead developability assessment, manufacturing line development and early process development. Track and oversee projects by maintaining an overview of the project goals, activities and commitments, and timelines of project teams, in line with strategic priorities. Manage and optimize project plans and resource assignments with the aim to manage/mitigate risks. Align with RLT LT project strategy and resourcing. Regular project/portfolio updates to IDU LT. Contribute to vendor/CRO evaluations, coordination of outsourcing requests, budget monitoring and communication, evaluation of external collaborations and due diligence. Plan R&D programs and recommends technological application programs to accomplish long-range objectives. Supports scientific decision making by providing advice and recommendations to global project teams. Develop concepts and propose approach, to address identified medical device/science/technology needs. Supply technical advice and counsel to other professionals and represent the organization in outside discussions and technical forums. Originate and apply complex concepts and propose new and unique approaches, methods, procedures and designs with regular use of creativity and originality to research and/or development. Assure continuity of products and processes assessment feasibility, research, design, development, compliance to customer and non-customer requirements, transfer to production. Focus on implementing and executing in own area of expertise provides thought leadership in own area. Provides leadership direction, determining and developing approach to solutions by coordinating multiple resources to solve complex problems. Minimum Requirements: PhD with a strong background in Radiochemistry and radio-isotope production technologies desired 5+ years of relevant radio/pharma experience, including industrialization of radio-isotopes Previous track record of success in leadership position, working with international and multidisciplinary development teams. Ambitious, yet highly collaborative and fully committed to team-s and project success. Result- and quality oriented. Able to deal with conflicting interests and willing to make compromises to ensure project progress. Excellent project management skills, organizational and team management skills, interpersonal communication, strong verbal and written communication. Creativity with demonstrated critical thinking and problem-solving skills, ability to pay attention to detail but also see a bigger picture. Comfortable with ambiguity and change, eager and fast learner willing to adopt new tools and processes. Ability to operate in a fast-paced dynamic environment and effectively process multiple avenues of communication and requests in parallel Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Alternative Location 1 Ivrea, Italy Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary BioMedical Research (BR) is the global pharmaceutical research organization of Novartis. With approximately 6,000 scientists and physicians around the world, our research is focused on discovering innovative new drugs that will change the practice of medicine. We have an open and entrepreneurial culture, encouraging collaboration to make effective therapies. At BR, our mission is to discover innovative medicines that treat disease and human health. To do that, our scientists need cutting-edge, state-of-the-art computing systems. With Research Informatics (RX), BR is making a strategic investment into informatics capabilities and is positioning itself to deliver the systems and services that are critical to the future of drug discovery. The Scientific Data and Products (SDP) group in RX builds and applies excellence in product and data management to continuously improve the impact and value of software and data to Biomedical Research. We deliver intuitive, intentional, and integrated software solutions that create a frictionless user experience. About the Role Purpose of the role: As Product Manager Drug Candidate Selection, you play a leading role in defining the future of our suite of software applications used by over 2,000 scientists in BR to search, analyze, and visualize project data to derive insights and drive high-quality decisions in our drug candidate selection process – both for classical small molecules as well as new therapeutic modalities. Key Responsibilities You combine your knowledge of informatics and chemistry/biology applied to drug discovery with your matrix leadership skills to manage and evolve a high-impact product consisting of a portfolio of chemistry and new therapeutic modalities software applications. Together with a Product Operations Manager and an Engineering Lead, you will co-lead a matrixed product team, ensuring the initiatives you lead contribute to an intentional, integrated, and capability-based product architecture and continuously increase the value to drug discovery in BR. You provide scientific expertise to the product team, sharing a deep understanding of drug discovery data including how to integrate and visualize scientific data from multiple disparate sources (e.g. chemical structures, dose response, and structure activity relationships). You collaboratively provide strategic context and focus to the teams, act as facilitator to prioritization, and cultivate good team-based decision-making practice to increase the value of the Product towards the strategic mandate of your Product Line. You actively and transparently manage, and communicate to, all key stakeholders to co-create visions and roadmaps for the initiatives you lead, and you define how we measure their success and value delivery. This includes partnering with multiple providers as well as the large community of system users, meeting frequently with key stakeholders to set the product roadmap. You shape your teams’ culture and processes for success by exemplifying excellence in leadership and product management. Role Requirements Leading effectively in a co-leadership model inside of a global matrix organization. Ability to effect change, manage conflict, and create alignment through direct and indirect influence. Creativity in identifying, encouraging, and accelerating innovative solutions. Domain expertise in core drug discovery disciplines such as chemistry and new therapeutic modalities (e.g. xRNA, RLT, complex biologics). Experience in managing complex suites of interdependent scientific applications and data sources. Experience with chemistry related data management, analysis, and visualization in a drug discovery setting. Agile mindset and experience with Agile software development. 7+ years of experience in an informatics related role in a drug discovery matrixed environment. Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll Receive : You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity & Inclusion : Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Join our Novartis Network : If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland OR Ivrea, Italy Role Purpose: We are looking for experience in the field of the industrialization of Radioisotope production and related technologies, with an emphasis on isotope separation technologies and isotope development supporting our growing portfolio. Our Unit is driving successful execution of a wide range of isotope-related projects. This starts with early strategic and operational discussions on isotope production technologies, assembly of internal teams and execution of desired strategy, up to technical leadership of early process development and the developability assessment of chosen isotope separation technologies. You will be reporting to the Head of the Global Isotope Development Unit. You will be leading an Isotope Project Team consisting of Isotope Project Leads from different scientific areas who act as members of the development project teams by optimally setting up people, assets, and equipment to best serve project needs according to priority and ensure timely delivery of high-quality products and solutions. About the Role Major accountabilities: Work collaboratively with cross-functional and multidisciplinary teams, spanning multiple NVS global sites to discover and develop efficient RLTs. Build and lead internal Project management team of experimental scientists and project leads. Seek technical and operational input from key stakeholders to build the project execution plan. Lead internal project meetings. Collect and interprets data to advance project, adapts strategy, and addresses the right scientific questions. Ensure team discussions and decisions are summarized in minutes. Ensure that key milestones and go / no go criteria are data driven and clearly defined. Own quality of project information and make sure project information is accurate and included in the system(s) in a timely matter. Guide projects with respect to isotope approaches and technologies and leads corresponding efforts. Lead developability assessment, manufacturing line development and early process development. Track and oversee projects by maintaining an overview of the project goals, activities and commitments, and timelines of project teams, in line with strategic priorities. Manage and optimize project plans and resource assignments with the aim to manage/mitigate risks. Align with RLT LT project strategy and resourcing. Regular project/portfolio updates to IDU LT. Contribute to vendor/CRO evaluations, coordination of outsourcing requests, budget monitoring and communication, evaluation of external collaborations and due diligence. Plan R&D programs and recommends technological application programs to accomplish long-range objectives. Supports scientific decision making by providing advice and recommendations to global project teams. Develop concepts and propose approach, to address identified medical device/science/technology needs. Supply technical advice and counsel to other professionals and represent the organization in outside discussions and technical forums. Originate and apply complex concepts and propose new and unique approaches, methods, procedures and designs with regular use of creativity and originality to research and/or development. Assure continuity of products and processes assessment feasibility, research, design, development, compliance to customer and non-customer requirements, transfer to production. Focus on implementing and executing in own area of expertise provides thought leadership in own area. Provides leadership direction, determining and developing approach to solutions by coordinating multiple resources to solve complex problems. Minimum Requirements: PhD with a strong background in Radiochemistry and radio-isotope production technologies desired 5+ years of relevant radio/pharma experience, including industrialization of radio-isotopes Previous track record of success in leadership position, working with international and multidisciplinary development teams. Ambitious, yet highly collaborative and fully committed to team’s and project success. Result- and quality oriented. Able to deal with conflicting interests and willing to make compromises to ensure project progress. Excellent project management skills, organizational and team management skills, interpersonal communication, strong verbal and written communication. Creativity with demonstrated critical thinking and problem-solving skills, ability to pay attention to detail but also see a bigger picture. Comfortable with ambiguity and change, eager and fast learner willing to adopt new tools and processes. Ability to operate in a fast-paced dynamic environment and effectively process multiple avenues of communication and requests in parallel Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Role Purpose: Join the Pharmaceutical Development (PHAD) Specialty Unit as an Associate Director – Drug Product Project Leader (DPPL) for drug product formulation and process development of parenteral innovative medicines, especially xRNA therapeutics and radioligand therapies (RLT). Advance the technology platform for both xRNA and RLTs and contribute to the development of patient-centric drugs. The position is ideal for an individual who is passionate about bringing transformational medicines to patients and working on exciting novel pharmaceutical products. The PHAD Specialty Unit is seeking an experienced Drug Product Project Leader (DPPL) to lead DP development sub-teams, be accountable for the DP development project strategy and represent DP development in the global CMC project team! Apply now and be a part of a team that is revolutionizing drug product development. About the Role Responsibilities As Drug Product Project Leader be the strategic lead of complex Drug Product Development projects (e.g. for Oligonucleotides or RLTs) within the PHAD Specialty Unit Lead and manage all formulation and process development activities for parenteral formulation development and parenteral manufacturing. Represent DP project teams in global CMC teams, providing strong quality awareness, scientific expertise, and project management skills. Develop a sound DP project strategy, including contingency planning and risk assessments, in line with overall Technical R&D project plan and guidelines. Monitor project plans and ensures timely availability of agreed timelines. Contribute actively to network deliverables and cross-functional initiatives, promoting collaboration and knowledge sharing. Act as an author, reviewer, or approver for PHAD owned documents, supporting submission writing and addressing inspection requirements. Ensures adherence to the EP/ LP project review process and high-quality documentation through relevant governance boards. Leads the Transfer Team and clinical development activities in alignment with TDP for late phase and LCM projects. Leads and / or contributes actively to respective Network deliverables and cross-functional workstreams/initiatives. Assesses, consolidates and negotiates resource needs (internal & external costs) and timelines. Lead budgeting process for DP activities. Requirements Ph.D. in Chemistry, Chemical Engineering, Pharmaceutical Technology or related disciplines with 7+ years of industry experience in parenteral drug product development, e.g. for Oligonucleotides (mRNA, siRNA, ASO) or Biologics (ADC, proteins), OR Master's degree with 9+ years of biopharmaceutical industry experience. Broad and profound understanding of development activities and processes in pharmaceutical sciences (parenteral, aseptic, solution, and/or suspension) Strong knowledge of laboratory and/or technical tools ((e.g., Quality by Design, statistical software, Process Analytical Technology). Familiarity with devices such as pre-filling syringes, vials, and combination products is an advantage. Strong scientific leadership skills. Basic / Advanced skills in Data Analysis and Data Visualization, including application of data science tools Strong knowledge of relevant GLP, GMP regulations and policies requirements in parenteral Drug Product development and manufacturing. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary To provide strategic, medical and scientific guidance and leadership for the development of multiple experimental agents in the Translational Clinical Oncology (TCO) portfolio beginning with input to early Target identification and continuing through to the Transition Decision Point. Formulate actionable development plans with the Development Organization to ensure rapid and seamless decision making and transitions of portfolio molecules and other assets. Provide scientific and clinical leadership to inform potential external innovative programs and business development in strategic areas of focus for the company. About the Role Key Responsibilities: Serve as an Early Clinical Development Area Leader for TCO, overseeing and implementing innovative clinical strategies for multiple molecules/assets that are advancing clinical testing in strategic indications, ensuring that robust and comprehensive development plans are in place and implemented. Oversee physicians (including direct reports and others) with strong mentorship and attention to ensure the strategic and operational aspects of their programs align with the overall oncology strategy and to foster their career development. Represent TCO programs and program strategy at governance boards in BR (e.g., TCO-Leadership Team (LT), Integrated Cancer Decision Board (ICDB), Discovery & Translational Board (DTB) and across the organization (e.g., Oncology Development Unit (ODU-LT), Therapeutic Area Leadership Team (TAL). Provide senior leadership and clinical input to clinical studies and pre-clinical research projects under their responsibility, effectively integrating their medical knowledge with expertise of colleagues in a wide range of other disciplines (e.g., Clinical Pharmacology, Biostatistics) to optimize the clinical development strategy, including supporting subsequent registration trials. Critically review and provide constructive feedback on documents for programs and studies under supervision including but not limited to protocol, Investigators Brochures (IBs), and health authority responses. Provide strategic input on internal and external assets and portfolio areas, representing TCO in Business Development and Licensing due diligence reviews and integrations. Lead or help oversee external collaborations, partnering closely with colleagues across the company. Play leadership roles in early development committees and initiatives by actively contributing strategic advice (e.g., the Study Concept Review Board and Protocol Review Committee). Apply medical knowledge to guide the safe, ethical and efficient conduct of own trials. Strive to maintain or exceed compliance obligations for Good Clinical Practice guidelines and Novartis Standard Operating Procedures. Liaise with outside experts, investigators, and regulatory authorities in oncology early clinical development First in Human (FIH) trials and represent projects to those groups and authorities. Write and review abstracts/manuscripts for presentation/publications at internal/external meetings. Mentor and serve as an educational resource and expert within Biomedical Research (BR) and across the organization. Essential Requirements: This hybrid position will be located at the Basel campus. This position will require 20-25% travel as defined by the business (domestic and/ or international). MD degree and PhD-level basic science required (PhD not required). MD / PhD preferred. Board-certification (or equivalent expertise) in Hematology-Oncology (heme-onc). Minimum 7 years’ experience leading complex global early phase hematology-oncology clinical programs from the pharma/biotech industry plus credible experience from an academic medical center. In case of no industry experience, substantially longer academic experience in translational hematology/oncology and substantial clinical study experience. Recognized as a Heme-Onc expert with a substantial record of quality scientific publications and international recognition for expertise. Interpretation of preclinical data in hematology/oncology (molecular biology, pharmacology, pharmacokinetics, and toxicology). Working knowledge of the application of PharmacoKinetics (PK) / PharmacoDynamics (PD) and biostatistics to clinical development and trials. Proven ability to analyze and interpret efficacy and safety data relating to oncology. Knowledge of Good Clinical Practices (GCP) and world-wide regulatory requirements relating to clinical trials and oncology. Excellent medical/scientific writing and oral communication/presentation skills. Proven ability to manage and develop a team. Outstanding scientific mentor; inspires others. Excellent personal ethical integrity and commitment to improving outcomes for patients with malignancies. #LI-hybrid Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary #LI-Hybrid Location: Basel, Switzerland Are you a seasoned IP leader ready to shape the future of pharmaceutical innovation at a global scale? At Novartis, we’re seeking a Global Head of IP Transactions to lead high-energy and high-impact patent and IP diligence across more than 100 M&A and BD&L deals annually. This is a unique opportunity to influence strategic decisions, collaborate with top-tier legal and business teams, and drive IP excellence for the most transformative medicines in the world. Join us in a role where your expertise will directly support breakthrough therapies and deliver lasting value to patients and society. About the Role Key Responsibilities: Coordinates, manages, leads, and drives the IP diligence and strategy for transactions (M&A and BD&L), using the support of all enterprise, legal, and IP functions in the analysis of IP issues (patents, trademarks, trade secrets), resulting in proactive, timely, thorough, and comprehensive advice on all relevant issues. Ensures clear, well-communicated, and accurate IP advice for all M&A and BD&L deals, recognizing the time-sensitive nature of transactions requires constant attention also during non-standard working hours. Develops and drives the IP and regulatory transaction governance framework, establishes appropriate tools and processes, and leads high-visibility, complex global IP transactions projects. Advises the Global Head IP and the Global Head Legal Transactions, as well as other senior business leaders, on IP transactions and risk exposure, including strategies for minimizing adverse consequences. Builds strong interface with M&A/BD&L colleagues to ensure transactions are supported by IP staff trained and equipped to advise on all IP aspects of transactions and manages external counsel providing diligence information and contract clauses. Ensures exchange of information and know-how across the enterprise and provides training, with the goal that in-house and external lawyers take a consistent and proactive approach in effectively dealing with IP transactions, and that stakeholders are advised early and proactively of IP issues impacting the deal business cases. Leads the IP Transactions team, ensuring that their services are timely, proactive, targeted, and of high quality. Retains and develops key talents within IP, particularly in IP transactions. Member of IP Leadership Team (IPLT) and Transactions Legal Leadership Team (TLLT) Essential Requirements: Law school graduate (Common or Civil Law) with an additional science degree, Common Law and admission to the bar preferred; Patent attorney qualification required Extensive, multi-year IP transactions and diligence experience within a pharmaceutical company or with health care clients, including experience leading a team Sound knowledge of related following disciplines: Regulatory, Antitrust, and Contracts paired with a good understanding of Corporate, Tax Proven ability to deal positively when working under time pressure and with demanding clients as well as in handling a high volume of activity involving multiple, often complex projects simultaneously Proficiency in English (written and spoken), other languages are a plus Benefits and Rewards: Company Pension Plan, Life and Accidental Insurance, Meals Allowance or Canteen in the office, Flexible working hours. Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Commitment to Diversity and Inclusion Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland OR Ivrea, Italy Role Purpose: Act as Isotope Project Lead (IPL) by providing the specialist knowledge and expertise as Subject Matter Expert (SME) of radioisotope production and purification with particular focus on assessing, developing, and optimizing new technologies that support RLT products Life Cycle Management (LCM). Develop, optimize and transfer radioisotopes production and purification/separation processes. This is done in close collaboration with the relevant development centers, and Contract Manufacturing Organizations (CMOs). About the Role Major accountabilities: Manage inter functional project plan and budget using the Project Planning tool or System Identify issues and potential bottlenecks within projects and proposes options Contribute to the Radioisotope TRD-related activities. Ensure constant technological survey on the field of radioisotopes production. Apply scientific/technical expertise to identify new programs of interest for the company and support their development from early evaluation up late phase supply. Participate to development programs and activities around isotopes in adherence with global Isotope strategy and objectives within agreed timelines and budget, timely report key advancements and challenges. Identify strategic external partners for the activation of research collaboration agreement to develop new production technologies/ access to innovative isotopes. Implements strategic policies when selecting methods, techniques, and evaluation criteria for obtaining results. Establishes and assures adherence to budgets, schedules, work plans, and performance requirements. Represents area as core member in the Global Project Teams for defining global scientific strategy for development up to submission and approval in major markets of assigned product(s). Reporting of technical complaints / adverse events / special case scenarios related to Novartis products within 24 hours of receipt -Distribution of marketing samples (where applicable) Minimum Requirements: BSc. in Chemical Engineering, Pharmaceutical Technology, or equivalent scientific degree. Desirable MSc., PhD or equivalent experience. Desirable degree in Radiochemistry and strong scientific knowledge in nuclear medicine Successfully demonstrated several years (minimum of 5 years) of directly related experience in a scientific area or Ph.D. or equivalent Proven Project Leadership in all project phases Proven process understanding (Pharma, GMP, Validation and Regulatory aspects). Sound experience of data handling and applied statistics is a must. Strong understanding of risk assessment and risk management fundamentals/tools Quality-oriented with attention to detail Excellent verbal and written communication skills Excellent problem solving and decision-making skills Defining and implementing productivity improvement measures. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Role Purpose: Are you energized by the challenge of transforming scientific innovation into life-changing therapies? Does the prospect of steering oral dosage form development, driving technical excellence, and leading projects with real business impact resonate with your ambitions? If you thrive in environments where experimental ingenuity meets strategic oversight—and where your communication and stakeholder management skills truly make a difference—then keep reading. Does this describe you? You see solutions where others see obstacles, and you relish the opportunity to advance cutting-edge small molecules into oral dosage forms. You are passionate about building reliable processes, ensuring regulatory compliance, and collaborating across disciplines to deliver quality drug products for clinical trials and commercial supply. If you’re seeking a pivotal role that empowers you to shape the future of pharmaceutical innovation, take the next step towards joining Novartis as the Senior Expert Science and Technology for Oral Dosage Form development About the Role As you consider taking on this influential position, here’s what you can expect from the role’s primary responsibilities. Each aspect is designed to challenge and inspire, ensuring your expertise finds its fullest expression: Oversee complex projects with significant business impact, making informed decisions from diverse data sources and actively mitigating risks to achieve project goals. Lead formulation and technical development activities for drug product manufacturing on assigned projects. Supervise development, scale-up, registration, and validation of drug substance, particle engineering, and drug development programs in accordance with Quality, HSE, and cGMP standards. Manage the manufacturing process for clinical materials, collaborating with supporting technical areas as needed. Resolve process challenges across multiple unit operations by employing both experimental methods and process simulation/modeling techniques. In this role, you will harness advanced data science and mechanistic modeling to inform every stage of development and scale-up, ensuring data-driven decisions underpin formulation strategies and process optimization. Your expertise in extracting actionable insights from complex datasets will help accelerate innovation, streamline technology transfer, and deliver robust manufacturing solutions that meet the highest standards of quality and regulatory compliance. What you’ll bring to the role: Advanced degree in a relevant scientific field, ideally in Pharmaceutical Technology. Minimum 3 years of industry experience in the development of pharmaceutical formulations for small molecules. Language English (mandatory). German or French (optional) Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary We are seeking a highly motivated and experienced human geneticist. This role requires strong strategic and leadership skills, as well as expertise in genetics with a proven ability to identify the causal drivers of disease. You will be adept at leveraging these approaches within an interdisciplinary team to foster innovation and discover novel targets. As the site lead for Basel, you will have the opportunity to directly and indirectly lead a small team. This position is part of the Human Genetics & Targets group within the Discovery Sciences (DSc) department in Biomedical Research (BR) at Novartis. The DSc Human Genetics & Targets team is a global group of computational and experimental scientists dedicated to validating or invalidating genetics-driven target hypotheses. The team's extensive expertise in genetics analytics, biology, and translatable models is enhanced by DSc's capabilities in AI, functional genomics, chemical biology, and more. The team collaborates with disease area specialists to not only identify disease associations but also to understand the underlying disease mechanisms and advance drug discovery projects to benefit patients in need. About the Role Your responsibilities will include, but are not limited to: Leading a small team and working within a larger genetics computational group to plan, develop, and implement human genetic strategies for drug discovery projects in alignment with department and company goals Work with interdisciplinary project teams across a variety of disease areas to deliver (fit-for-purpose) human genetics analyses for drug discovery impact Guiding the use of population scale biobanks and serving as a champion for a human genetic cohort Coaching and mentoring the next generation of genetics experts Bringing scientific curiosity and enthusiasm to make discoveries in a collaborative and team-focused environment Engaging as an insightful and proactive member of the DSc Human Genetics Data Science team to shape the strategic direction of the team and broader BR genetics efforts What you’ll bring to the role: PhD with 7+ years of post-graduate work or equivalent experience in genetics Experience analyzing and interpreting human genetics data is a must Extensive experience with the management and analysis of large biobank data is a must and experience of multiple biobanks is preferred. Strong leadership skills and experience leading computational scientists Drug discovery experience in an industry stetting is encouraged but not required Experience with additional ‘omics data (RNA sequencing, epigenetics, proteomics) and NGS data A curiosity for emerging technologies and methods Exceptional collaboration, communication and problem-solving skills, learning agility, and an interest in engaging with peers for the design and implementation of new ideas A strong publication record Fluency in Python, R, SQL and/or other relevant programming languages Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve ​ Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10053562 Oct 10, 2025 Switzerland Summary We are seeking a highly motivated and experienced human geneticist. This role requires strong strategic and leadership skills, as well as expertise in genetics with a proven ability to identify the causal drivers of disease. You will be adept at leveraging these approaches within an interdisciplinary team to foster innovation and discover novel targets. As the site lead for Basel, you will have the opportunity to directly and indirectly lead a small team. This position is part of the Human Genetics & Targets group within the Discovery Sciences (DSc) department in Biomedical Research (BR) at Novartis. The DSc Human Genetics & Targets team is a global group of computational and experimental scientists dedicated to validating or invalidating genetics-driven target hypotheses. The team's extensive expertise in genetics analytics, biology, and translatable models is enhanced by DSc's capabilities in AI, functional genomics, chemical biology, and more. The team collaborates with disease area specialists to not only identify disease associations but also to understand the underlying disease mechanisms and advance drug discovery projects to benefit patients in need. About the Role Your responsibilities will include, but are not limited to: Leading a small team and working within a larger genetics computational group to plan, develop, and implement human genetic strategies for drug discovery projects in alignment with department and company goals Work with interdisciplinary project teams across a variety of disease areas to deliver (fit-for-purpose) human genetics analyses for drug discovery impact Guiding the use of population scale biobanks and serving as a champion for a human genetic cohort Coaching and mentoring the next generation of genetics experts Bringing scientific curiosity and enthusiasm to make discoveries in a collaborative and team-focused environment Engaging as an insightful and proactive member of the DSc Human Genetics Data Science team to shape the strategic direction of the team and broader BR genetics efforts What you-ll bring to the role: PhD with 7+ years of post-graduate work or equivalent experience in genetics Experience analyzing and interpreting human genetics data is a must Extensive experience with the management and analysis of large biobank data is a must and experience of multiple biobanks is preferred. Strong leadership skills and experience leading computational scientists Drug discovery experience in an industry stetting is encouraged but not required Experience with additional -omics data (RNA sequencing, epigenetics, proteomics) and NGS data A curiosity for emerging technologies and methods Exceptional collaboration, communication and problem-solving skills, learning agility, and an interest in engaging with peers for the design and implementation of new ideas A strong publication record Fluency in Python, R, SQL and/or other relevant programming languages Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Data and Digital Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary The *Senior Clinical Development Director (CDD) in the Cardio Renal & Metabolic (CRM) Development Unit is responsible for leading the strategic planning and management of the assigned clinical program(s) from an end-to-end clinical development perspective. As a Senior CDD in the Cardiovascular/Metabolic TA, you will have oversight of the clinical development for the assigned programs and drive the execution of the clinical development plan. In addition, you will enable an empowered organization, which can navigate in a matrix environment and adjust quickly to business needs. About the Role Main responsibilities of this role are: • Providing clinical leadership and strategic input for all clinical deliverables in the assigned project or section of a clinical program. Clinical deliverables may include clinical sections of individual protocols or sub studies consistent with the Integrated Development Plans (IDP), clinical data review, program specific standards, clinical components of regulatory documents/registration dossiers, and publications • Leading development of clinical sections of trial and program level regulatory documents • Driving execution of the section of the clinical program in partnership with global line functions, assigned Global Trial Directors (GTDs), and regional/country medical associates, if applicable • Overseeing/conducting ongoing medical and scientific review of clinical trial data with Clinical Scientific Expert(s) with appropriate oversight from Medical Lead • Supporting (Sr.) GPCH in ensuring overall safety of the molecule for the assigned section and may be a core member of the Safety Management Team, supporting overall program safety reporting in collaboration with Patient Safety • As a clinical expert, supporting the (Sr.) GPCH or CDH in interactions with external and internal stakeholders and decision boards • Contributing to scientific training of relevant Novartis stakeholders on the disease area and compound/molecule. May serve as speaker for franchise medical/scientific training and may be the Program Manager of other associates Minimum Requirements • Advanced degree in life sciences / healthcare (or clinically relevant degree) is required. PharmD or PhD is strongly preferred • Fluent oral and written English • Minimum 5 for CDD and 7 years experience for Snr CDD experience in clinical research or drug development • Working knowledge of the assigned disease area (Cardiovascular) is desired with proven ability to interpret, discuss and present efficacy and safety data relating to clinical trial(s) or program level • Demonstrated ability to establish effective working relationship with key investigators • Working knowledge of GCP, clinical trial design, statistics, and regulatory and clinical development processes • Strong communication skills with the ability to work in a cross functional and global organization Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10059955 Aug 19, 2025 Switzerland Summary Join our team in Pharmaceutical & Analytical Development (PHAD) and be a part of cutting-edge parenteral drug product development. Contribute to the advancement of novel technology platforms such as Oligonucleotides, and work on the Novartis main Campus in Basel. This is your chance to make a significant impact in the biopharmaceutical field and be at the forefront of bringing life-changing medicines to patients worldwide. The PHAD specialty Unit is seeking an experienced Formulation Drug Product Project Leader (FPL) to lead drug product formulation and manufacturing process development. Apply now and be a part of a team that is revolutionizing drug product development. About the Role Major accountabilities: Be accountable for all formulation and manufacturing process deliverables including scientific documentation, design of experiments of parenteral products, batch records, deviations, change controls, CAPAs, tech transfer, and reports. Drive DP development, manufacturing process transfers and supply activities with scientific and technological excellence Work closely with cross functional teams both internal and external to provide technical input for the development and manufacturing process (including CRO and CMOs). Provide technical support to compile technical regulatory documentation and responses to regulatory agencies as needed. Assist with writing and reviewing of CMC documentation associated with project or manufacturing changes. Key Skills Formulation Expertise: Experience developing injectable drugs, including solutions, suspensions, and aseptic formulations. Knowledge of RNA-based therapies (e.g., siRNA, mRNA) and drug delivery systems like pre-filled syringes or vials. Process Development : Skills in designing manufacturing processes and transferring them to production environments. Familiarity with aseptic drug manufacturing and methods like QbD. Regulatory Knowledge: Understanding of GMP and preparing technical documentation for regulatory submissions. Analytical Thinking: Designing experiments (e.g., DoE) and analyzing data to improve formulations and manufacturing processes. Collaboration & Communication: Strong teamwork skills for working with internal teams and external partners (e.g., CROs/CMOs). Clear communication and ability to write reports, technical documents, and regulatory responses. Problem-Solving: Ability to handle deviations, implement corrective actions, and improve manufacturing processes. Innovation: Interest in advancing RNA drug delivery platforms and contributing new ideas to the field. Preferred Technical Experience Working knowledge of oligonucleotide-based therapies (e.g., ADCs, proteins, RNA-based drugs). Familiarity with process development for clinical-grade parenteral drug products. Proven experience in related fields such as pharmaceuticals, biotechnological product development, and advanced drug delivery platforms. Required Qualifications: Ph.D., Master-s or Bachelor-s Degree in Chemistry or related disciplines: With 2+ years (Ph.D.), 5+ years (Master-s), or 8+ years (Bachelor-s) biopharmaceutical experience. Proven expertise in formulation and manufacturing process development for parenteral and aseptic products. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary As Legal Counsel supporting Global Medical Affairs and Quality, you'll provide strategic guidance on GxP matters across Development and Biomedical Research. This high-impact role offers a unique opportunity to shape compliance and influence decision-making in a dynamic, science-led environment. If you're passionate about partnering with cross-functional teams and driving excellence in global standards, we’d love to hear from you. #Hybrid Location: Basel, Switzerland About the Role Key Responsibilities: Strategic Legal Partnering – Lead legal support for Global Medical Affairs (GMA), including Medical Affairs Excellence and Governance, evidence generation, Scientific Communication and field medical activities. Legal & Medical Governance Leadership – Provide pragmatic legal counsel to advance GMA strategies across the enterprise providing pragmatic counseling and proactively identifying opportunities and solutions that reflect a solid understanding of needs across the Novartis enterprise and RDC continuum. Global Standards & Controls – Advise on creation and implementation of global standards and processes for medical programs (e.g., Investigator Initiated trials, non-interventional studies, and managed access programs). Evidence Generation Strategy – Counseling on the development of global evidence generation strategies in-volving Phase 3, Phase 4, real world evidence, investigator-initiated trials and in-licensing programs for various products to address US and top market needs and address priority evidence gaps to optimize access and clinical adoption. Strategic Scientific Communication Compliance – Guide compliant execution of medical education and communications across the Global, International and U.S. Medical Affairs organizations and embed best practices. Cross-Functional Coordination – Ensure consistency across global, international, and U.S. Medical Affairs. Regional Support – Provide legal guidance to regional Medical Affairs and Quality teams. Governance Board Engagement – Assist and deputize for Head Legal Global Medical Affairs, PS&PV and Quality on cases brought to GGO Governance Board. Training & Oversight – Deliver legal training and compliance guidance across global functions on risks in the Medical Affairs area. R&D Quality Legal Support – Advise on Quality (GxP) issues in Biomedical Research and Development collab-orating with Quality Assurance, Legal Operations and all relevant teams. Compliance & Risk Management – Ensure adherence to laws, regulations, policies, and legal governance. Ad-vise on compliance issues, policies and operations as they relate to medical, GxP activities, and coordinate pharmacovigilance related matters with the R&D Legal Head Safety. External Landscape Monitoring – Track legal and industry trends to proactively advise senior leaders. Essential Requirements: Law Degree or equivalent & licensed to practice law (e.g. admitted to the Bar or equivalent Proficiency in English required – spoken & written Demonstrated post qualification experience required: ideally gained within a healthcare / pharmaceutical environment, or alternatively, with a top-tier law firm representing healthcare & technology clients. Strong proficiency in analyzing complex legal issues - Excellent problem-solving skills Strong verbal & written communication skills; high ability to influence and negotiate. Demonstrated competence in working within tight timelines and demanding clients/business partners. Sound experience in handling a high volume of activity involving multiple, complex projects simultaneously. Professional & culturally sensitive work ethic. Demonstrated competence in high pressure environments – with a proactive approach and curious mindset. Ability to work collaboratively in cross-functional and multi-cultural teams. Strong Business acumen and ability to manage change. Commitment to Diversity & Inclusion: We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in any order to receive more detailed information about essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10062228 Sep 22, 2025 Switzerland Summary Location: Basel, Switzerland Role Purpose: The Therapeutic Data Strategy Director (TDSD) bridges science and operations by defining how the clinical data strategy is operationalized across the complete data flow within GCO. The TDSD is responsible for ensuring data regulatory compliance, the availability of End-to-End (E2E) standards, that instruments and devices are thoroughly discussed, defined, and finalized prior to the database build and that the operational impact of any new changes are known, , mitigated, and captured in the appropriate knowledge database. In collaboration with the GPT, GCT, and CTT, the TDSD aligns on the fit for purpose data package as part of a program / indication level quality by design to support data strategy needs in the drug development lifecycle of a molecule or across therapeutic area (TA) within an assigned unit in Novartis. This role creates and implements strategies for the end-to-end data product, ensuring application of Novartis clinical data standards and defining the clinical data acquisition and data review, strategy to support the submission of our clinical programs. The TDSD is responsible for ensuring that delivery and timelines are met with quality, whilst ensuring cost efficiencies and stakeholders- satisfaction. About the Role Creation and Execution of operational data strategy: Collaborate with the Global Program Clinical Head (GPCH) to establish and maintain a data strategy for the clinical data standards of the assigned Therapeutic Area, as well as the design, collection, processing, transformation, of clinical data supporting the needs for reporting and submission. Impact assessment of proposed data collection and analysis Drive capability inputs to data team-s resource algorithm based on future incoming demands Matrix data operations leader who is the single focal point for the sustained industry leading cycle time for data product and ensures compliance with relevant Novartis processes Ensures the provision of resource with the skillset to develop robust & lean E2E specification. Leads the full spectrum of standard development and compliance across their portfolio. Consults to drive quality into the study protocol and operational processes. Driving implementation of a lean global data strategy and define minimum data requirements Ensure the minimum data requirements remain intact and understanding the operational impact e.g., resources, and time of any amendments as well as work with clinical development, analytics and regulatory line functions to understand the scientific, clinical, statistical and regulatory impacts. Support assessment on opportunity to capitalize on non-traditional options (e.g., historical data, synthetic data, cross-sponsor shared control arms, adaptive designs, pragmatic trials, decentralization, etc.). Work with COPH and Vendor Program Strategy Director (VPSD) to define the provision of ancillary data, including vendor capabilities. Author the Operational Data Strategy Section of Operational Execution Plan (OEP) (key customers, dataflow, and targets to generate Data-as-a-Product (DaaP) etc.). Establishes a -performance-oriented culture- that is driven / supported by analysis of real-time activity and quality metrics Contribute to the development of the Data Operations organization. Define/contribute to the development of long term goals and operating policies through his/her leadership role on the management team. As an extended member of the Data Operations Leadership Team support functional excellence for Data Operations by contributing to the definition of the strategic goals and operating policies, and leading/contributing to strategic initiatives in line with the overall Data Operations strategy. Support the BD&L activities from CDO perspective. End-to-End Ownership of the Clinical Data Flow: Ensure that data is collected and reviewed as efficiently as possible, and that extraneous data is not procured. Drives implementation of a lean global data strategy and defines fit for purpose data quality requirements sufficient to support good decision making and meet regulatory requirements. Collaborates cross-functionally to define quality by design review process to ensure fit for purpose data quality sufficient to support good decision making. Accountable for managing operational strategy around data cleaning and data review at portfolio level. Drives standards and processes to facilitate data right the first time. Act as point of escalation for data specific project management issues and for broader data demands (e.g. changing scope, addition of analysis/reporting events). End-to-End Standards Oversight & Lifecycle Management: Responsible for compliance with data requirements and the availability of end-to-end clinical data standards (data collection through analysis) for a program/molecule/indication. Influence and support the design of new clinical data standards as required at the enterprise/ therapeutic area level. Drives identification of needs, adoption and maintenance of data standards. Operational Project Management: Develop, communicate, and drive implementation of a global data operationalization strategy to deliver value-adding data; CDS supports and guides the Data Team (as part of the CTT) in ensuring the overall program /OEP strategy is aligned with execution. Establish key customers of Clinical Data and establish approach for future consumption. Works with the business to ensure adherence to timelines, adoption of the data strategy and delivery of the target data product quality. Accountable for managing the strategy of the data cleaning, review, and data related specifications at portfolio and study level. Ensure high quality, timely and efficient Data Operation deliverables for projects and trials partnering with other Data Operations functions within assigned Development Unit or program. Work alongside the Operational Program Lead and Trial Lead to ensure all data related risks and issues are identified and mitigated. Link between business needs and technical development/deployment and technology usage in data operations. Influencer and interlocutor for adoption and compliance with company efficiency process and objectives within data workflow. Assesses / approves changes that impact the data collection strategy. Education: Minimum: Bachelor-s degree in life sciences, preferably with a statistics module. Desirable: Degree in statistics or mathematics. Experience/Professional requirement** :** A minimum of 10 years in a R&D regulated environment in a relevant pharmaceutical or health care company. Excellent understanding of end-to-end clinical data processing and the clinical trial operations space. Extensive knowledge and experience in ICH-GCP Process Control or ICH-GCP Quality Assurance systems and Health Authority regulations; Clinical Operations experience in these areas is preferred Demonstrated ability for leading initiatives with cross-functional teams and implementation of recommendations Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary The Clinical Development Medical Director (CDMD) is the clinical leader of a section of a clinical program (e.g., an indication, a new formulation, or a specific development phase), or a large, complex trial, under the leadership of the (Sr.) GPCH. About the Role Your responsibilities include, but are not limited to: Provide clinical leadership and medical strategic input for deliverables in the assigned project/program. Deliverables may include sections of individual protocols consistent with the IDP, data review, program specific standards, clinical components of regulatory documents/registration dossiers, and publications (e.g., IBs, Brochures, briefing books, safety updates, submission dossiers, and responses to Health Authorities) Drive execution of the section of the program in partnership with global line functions, assigned Global Trial Directors (GTDs), and regional/country medical associates Oversee/conduct medical and scientific review of trial data with Clinical Scientific Expert(s). May be the Program Manager of other associates (e.g.., CSE). May function as study medical monitor Support SR/GPCH in ensuring overall safety of the molecule. May be a core member of the Safety Management Team (SMT), and supports program safety reporting (e.g., PSURs, DSURs, and safety related documents) in collaboration with Patient Safety Support the Therapeutic Area Head (TAH) by providing medical input into IDP and CTP reviews and contributing/driving development of disease clinical standards for disease areas. Provide support to the (Sr.) GPCH or TAH in interactions with external partners (e.g., regulatory authorities, KOLs, data monitoring boards, AD Boards, patient advocacy groups), internal partners (e.g., CTT, Research, Translational Medicine, GMA, Marketing, HE&OR), and decision boards) Work with BR (Biomedical Research)/ Translational Medical Sciences) to drive transition of pre-PoC projects to DDP and with BD&L including target identification and due diligences together with additional matters Ensure career development of Program reports and clinical colleagues through active participation in performance management and talent planning processes. Provide on-boarding, training, & mentoring support Contribute to medical/scientific training of relevant Novartis stakeholders on the disease area and compound/molecule. May serve as speaker for franchise. May serve on or lead global initiatives (e.g., process improvement, training, SOP development, other Clinical Development line function initiatives) Minimal Requirements: MD (or equivalent medical degree) is required. Medical Board certification preferred. 4+ years Clinical practice experience (including residency) is preferred Possess advanced knowledge and clinical training in a medical/scientific area (e.g., internal medicine or sub-specialty) is required. 5+ years’ experience in clinical research or drug development from the pharma/biotech industry spanning clinical activities in Phases I through IV. 3+ years of contribution to and accomplishment in all aspects of conducting clinical trials (e.g., planning, executing, reporting, and publishing) in a global/matrix environment Showcase advanced knowledge of assigned therapeutic area Demonstrate ability to establish strong scientific partnership with key partners Need thorough knowledge of GCP, trial design, statistical analysis methodology, and regulatory/ clinical development process Have people management experience preferred, this may include management in a matrix environment. Global people management is preferred. Exhibit excellent business communication and presentation skills Possess strong interpersonal skills Adept with excellent negotiation and conflict resolution skills Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Job Description Summary The Clinical Operations Program Head (COPH) is accountable to deliver data-driven, actionable operational and strategic insights for execution of a clinical development program and all associated trials by representing GCO at the Global Clinical Team (GCT) as well as at the Global Program Team (GPT). The COPH is accountable to plan the strategic operationalization of clinical drug development programs and trials in line with the needs of the EPTs/GPTs. This specific COPH role may be focused within Immunology, CRM or Neuroscience programs. The COPH leads the GCO sub-team to determine the GCO operational input to planning prior to any given development tollgate and to prepare the Operational Execution Plan (OEP), which is authored and owned by the COPH. The OEP incorporates both data-derived insights as well as country insights which enable informed decision-making, identify complexity, enable the generation of risk mitigation plans to reduce chances of delays, allow easier adaption of actions, and ensure transparency of the GCO operational position and the downstream delivery of program and trial milestones. To do this, the COPH owns the early viability assessments and program and trial feasibility of the planned programs and trials. During the execution of the trial (concept sheet onwards), the COPH will continue to lead the GCO sub-team to ensure the progress of the trial is in line with the OEP, to proactively deploy mitigation actions whenever necessary to ensure timely delivery of the trial as per plan. Experienced leader guiding members of the organization through the GCO organizational evolution, the evolution of new “product aligned” ways of working and of our overall culture. He / she champions a product oriented agile mindset, fostering a culture of experimentation combined with accountable delivery and overall high performance. About the Role Major accountabilities: Lead operational delivery of the clinical development program and is responsible for the overall operational execution of the clinical program and related trials, as aligned with the IDP/CDP. Single GCO point of contact for assigned clinical development program and related trials. Key partner to GPCH during strategy, planning and execution stage of the program and related trials ensuring that the clinical science and strategy are consistently harmonized with an operationally feasible approach within the OEP-defined operational boundaries, so that the trials generate reliable information to answer the research questions and support decision making while protecting study participants. Leads operational delivery of the assigned program and related clinical trials and for all related strategic planning, prioritization of activities within that program and owns the early viability and feasibility assessment done by the GCO sub-teams as well as the development of operational scenarios for the execution of assigned programs and trials. Oversight and management of clinical trial budget for the assigned program and trials per OEP aligned with financial toll gates (e.g. IMB) and oversight of scope changes throughout the trial and program duration. Acts as a key partner to the GCO DU Head to use the operational insights developed with the GCO sub-team to actively shape the GDD DU strategy by driving the science of operations and GCO’s voice to ensure that the development strategy is operationally executable, thus contributing to both GCO and GDD DU mid to long term success. Is a key contact to senior leaders in GCO and beyond. Empowered to manage stakeholders, resolve conflict, and facilitate agreement. Actively monitor evolution and trends in Biopharmaceutical industry and may represent GCO and Novartis at Industry consortia. May be a member of Early Program Teams, providing an early and proactive assessment of operational viability of new clinical programs and ensuring that GCO’s assessment is correctly reflected in the overall program plans. In partnership with the GCO DU Head ensure that novel programs are reflected in the mid-long term GCO strategy and that GCO is prepared for their operationalization. The COPH champions a product oriented agile mindset, fostering a culture of experimentation combined with accountable delivery and overall high performance. Essential Requirements : Bachelors in life science/healthcare required; Advanced degree or equivalent education/degree in life sciences/ healthcare preferred (PhD/MD/ PharmD/ Masters) and 10+ years relevant experience in pharmaceutical drug development. Experience in managing associates globally and in management in a matrix organization. Proven ability to lead cross functional matrix teams applying product-oriented agile ways of working. Strong leadership, interpersonal and problem-solving skills. High resilience and ability to advocate and implement new ways of working. Extensive knowledge of clinical development processes, preferably extensive knowledge of Novartis late-stage development processes or high likelihood to develop it within 6 months after appointment. Proven ability to lead in times of organizational transformation and to lead across organizational boundaries. Strong knowledge of therapeutic area or high likelihood to develop it within 6 months after appointment. Strong matrix management skills for bridging stakeholders (business, scientific, technical) Strong relationship-building skills; can influence, negotiate with and motivate executive leadership Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary We are committed to fostering a source of versatile, commercially focused, and inspiring talent. As part of our ongoing quest to embody proactive thought leadership, we emphasize on sharing our enterprise strategies while remaining focused on addressing the unique country’s needs as a value-added solution focused partner. Join the International HEOR & PCO Team, a pivotal partner in International Value & Access, leading with excellence the evidence generation to demonstrate the value of our innovative medicine portfolio. An opportunity has arisen for an experienced Senior HTA Statistician to apply innovative statistical approaches to complex challenges in health technology assessment (HTA). This role offers the chance to lead the evidence synthesis of patient data from clinical, observational, and real-world data studies supporting HTA submissions, in a flexible and collaborative environment. The role is responsible for leading the design and execution of evidence-synthesis for HTA submissions incl. EU HTA JCA Dossier and for health economic models. Position applies methodological and analytical expertise to predict the value of Novartis assets and develop strategies on how best to demonstrate this to external decision makers. Role will strategically and effectively communicate, and tailor generated evidence to multiple stakeholder audiences. About the Role Key responsibilities: As part of the HEOR & PCO Team: Develop core global Indirect Treatment Comparison (ITC) plan for HTA, payer and other Access stakeholder assessments, submissions, and negotiations. Lead publications associated with these to meet business objectives. Provide strategic, methodological, and analytical support to regions and top countries with adaptation of the Indirect Treatment Comparison (ITC) for local HTA submissions and support the local assessment of HTA strategy. Coordinate data requirements across evidence generations functions (Clinical Development; Medical Affairs/Biostat and HEOR & PCO) to support Pricing & Reimbursement. Set-up systems internally to proactively capture key HTA analytic requirements across key international markets to inform and optimize key internal deliverables e.g., statistical analysis plans. Track key HTA statistics priorities and sequence them aligning with resource availability and risks. Identify need for preliminary ITCs to inform value proposition, development, pricing and commercial strategic forecast and decisions. Lead and facilitate the sharing of best practices and key learnings across regions, countries and cross-functional partners. Stay on top of innovative techniques, using robust analytical techniques leveraging available clinical data and published information to inform pricing and market access strategy. Collaborate with the MA Biostats team for trial analyses, HTA challenges, and statistical analyses. Act as a Strategic Partner for key partners from HEOR & PCO and International Value & Access (Therapeutic Area Access, Pricing) to ensure alignment to brand and commercial, access and evidence strategy. Ensure optimal utilization of comparative evidence through partnership with teams generating payer & promotional materials, generating regulatory dossiers and publications. Provide mentoring and coaching support to junior members of evidence modelling teams and across function. Essential requirements: The ideal candidate will possess a strong background in statistics, with relevant experience in HTA and clinical research. MSc/PhD in Statistics, Biostatistics, or a related field. Experience from pharmaceutical industry or life-science consultancy 6-8 years relevant experience in consultancy or pharmaceutical industry in Evidence Synthesis, Health Economics, Health Technology Assessment, or related area Strong understanding of clinical drug development and HTA-related regulations and processes Local HTA experience including experience with country HTA submissions Strong understanding of statistical methodologies for indirect treatment comparisons (ITCs) and population-adjusted indirect comparison (PAIC) Proficiency in statistical software such as R and/or SAS Strong interpersonal and scientific communication skills. Excellent problem-solving abilities and attention to detail Ability to lead in a matrix environment and work collaboratively in interdisciplinary cross-functional teams Location: This role can be based in the UK, London but also based in Basel, Switzerland and Dublin, Ireland. Benefits: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, be-cause of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary The primary focus of your projects will be the management, transformation, and integration of data derived from preclinical experiments, incorporating them into both existing and new infrastructure systems, to answer questions from drug discovery teams. About the Role Location: Campus Novartis Start: as soon as possible Duration: 6 months Key performance indicators: In collaboration with a mentor, you will contribute to drug discovery initiatives by developing practical analytical and visualization tools, using R or Python. This role requires handling diverse ‘omic datasets (such as mutational screening, RNASeq, and scRNASeq) within a high-performance computing environment, as well as researching and applying innovative methodologies. The successful candidate may also collaborate with multidisciplinary teams to integrate experimental data with publicly available resources to address critical scientific questions Minimum Requirements: Bachelor’s or Master’s degree in Computational Science/Bioinformatics or similar. Skills: Experience using R (Bioconductor/Tidyverse/RShiny) or Python/DASH. Experience applying workflows and software to visualize complex data sets. Experience addressing questions concerning target discovery, drug mechanism elucidation, and patient stratification using data sources related to cancer. Knowledge of biological sciences genetics & genomics. Clear communication to explain how and why an analytical method was used. Languages : English Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Reporting to the Region Europe V&A Head, with a dotted line to the Cluster Head, the ED is an active member of both the SERCE leadership team and the Region Europe Access leadership team and provides strategic direction to access leaders in each cluster country. The Executive Director, Value and Access for the SERCE Cluster leads the value and access function across the cluster, driving excellence in market access, pricing, & reimbursement. This senior leader is responsible for executing integrated access strategies to ensure optimal patient access to innovative medicines, aligning with International and Regional priorities while adapting to local market dynamics. The role also focuses on building and developing high-performing teams, fostering cross-functional collaboration, and shaping the external environment to support sustainable access. About the Role Key Responsibilities: Roll-out of the V&A deliverables to cluster countries and work in close collaboration with International V&A and the Region Europe V&A team​. Improve the collaboration with International V&A to ensure the needs of Cluster countries are communicated early on to help shape market access strategies, including HEOR. Utilizes sound understanding and knowledge of local healthcare systems to support countries in development and execution of V&A strategies. In close collaboration with International Pricing, chairs the Cluster pricing governance approval process.Partners with Medical Affairs, Commercial, Regulatory, Public Affairs, Communications & Patient Engagement to ensure robust launch readiness plans and integrated approaches to access. Build and maintain relationships with key external stakeholders (payers, HTA bodies, government agencies, patient organizations) to advocate for patient access and shape policy. Monitors and influences healthcare policy developments impacting access, collaborating with public affairs to create a favorable access environment. Represent Novartis in external governmental, payer, HTA, and patient advocacy forums, actively promoting access-related initiatives, shaping evidentiary standards, and supporting innovation in market access and patient outcomes through education and policy engagement. Accountable for access performance management, incl. metrics & KPIs being updated and relevant, and that are being tracked and impacted at each cluster country level with appropriate International support for all therapeutic areas. ​Role models ethical standards and contribute proactively to a credible image for Novartis in the Cluster. Leads and develops the value and access team, fostering leadership, talent, and critical capabilities across the cluster. Optimizes Value and Access resources and allocation: Advocates early resourcing where and when appropriate, while ensuring cost adherence in spend of V&A activities and resourcing. Ability to articulate and defend priorities and needs of access with strong influencing skills. Ensures all access activities adhere to governance, compliance, quality, and ethical standards. Essential requirements: At least 15 years of experience in the pharmaceutical industry, with significant senior leadership experience in market access, pricing, reimbursement, or health policy. Advanced degree in life sciences, health economics, public health, or related field; business qualification (e.g., MBA) is desirable. Experience in both country and regional/global roles; strong knowledge of key European markets and HTA-based systems. Proven track record in developing and executing access strategies and leading cross-functional teams. Strong business acumen, superior leadership, and influencing skills. Strategic and enterprise thinking, with flexibility to manage complexity. Location: This role is based in Basel, Switzerland Benefits: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, be-cause of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Reporting to the Region Europe V&A Head, with a dotted line to the Cluster Head, the ED is an active member of both the WEC leadership team and the Region Europe Access leadership team and provides strategic direction to access leaders in each cluster country. The Executive Director, Value and Access for the WEC Cluster leads the value and access function across the cluster, driving excellence in market access, pricing, & reimbursement. This senior leader is responsible for executing integrated access strategies to ensure optimal patient access to innovative medicines, aligning with International and Regional priorities while adapting to local market dynamics. The role also focuses on building and developing high-performing teams, fostering cross-functional collaboration, and shaping the external environment to support sustainable access. About the Role Key Responsibilities: Roll-out of the V&A deliverables to cluster countries and work in close collaboration with International V&A and the Region Europe V&A team. Improve the collaboration with International V&A to ensure the needs of Cluster countries are communicated early on to help shape market access strategies, including HEOR. Utilizes sound understanding and knowledge of local healthcare systems to support countries in development and execution of V&A strategies. ​ In close collaboration with International Pricing, chairs the Cluster pricing governance approval process.Partners with Medical Affairs, Commercial, Regulatory, Public Affairs, Communications & Patient Engagement to ensure robust launch readiness plans and integrated approaches to access. ​Build and maintain relationships with key external stakeholders (payers, HTA bodies, government agencies, patient organizations) to advocate for patient access and shape policy. Monitors and influences healthcare policy developments impacting access, collaborating with public affairs to create a favorable access environment. Represent Novartis in external governmental, payer, HTA, and patient advocacy forums, actively promoting access-related initiatives, shaping evidentiary standards, and supporting innovation in market access and patient outcomes through education and policy engagement. Accountable for access performance management, incl. metrics & KPIs being updated and relevant, and that are being tracked and impacted at each cluster country level with appropriate International support for all therapeutic areas. Role models ethical standards and contribute proactively to a credible image for Novartis in the Cluster. Leads and develops the value and access team, fostering leadership, talent, and critical capabilities across the cluster. Optimizes Value and Access resources and allocation: Advocates early resourcing where and when appropriate, while ensuring cost adherence in spend of V&A activities and resourcing. Ability to articulate and defend priorities and needs of access with strong influencing skills. Ensures all access activities adhere to governance, compliance, quality, and ethical standards. Essential requirements: At least 15 years of experience in the pharmaceutical industry, with significant senior leadership experience in market access, pricing, reimbursement, or health policy. Advanced degree in life sciences, health economics, public health, or related field; business qualification (e.g., MBA) is desirable. Experience in both country and regional/global roles; strong knowledge of key European markets and HTA-based systems. Proven track record in developing and executing access strategies and leading cross-functional teams. Strong business acumen, superior leadership, and influencing skills. Strategic and enterprise thinking, with flexibility to manage complexity. Location: This role is based in Basel, Switzerland Benefits: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, be-cause of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10061665 Sep 10, 2025 Switzerland Summary Location: Basel, Switzerland Role Purpose: Novartis holds a rich development portfolio of small molecules ready to develop into innovative patient centric oral dosage forms. As a Drug Product Project Leader working on oral dosage forms, you will lead and manage formulation and manufacturing activities linked to pharmaceutical development for small molecules (New Chemical Entities; NCE) for assigned projects. For this position, specific emphasis lies on bringing in-depth experience in applied data science, mechanistic modelling and simulation of pharmaceutical unit operations. You will lead drug product teams during all stages of development but with a focus on initial clinical phases. You will be working on oral Small Molecules and in particular on enabling formulation approaches. You will use your strong communication and influencing skills to effectively lead the drug product subteam. Your expertise will facilitate the creation of innovative and stable drug products suitable for human trials and commercial supplies. About the Role Your responsibilities will include but are not limited to: You lead and manage all Drug Product (DP) related technical development activities for assigned projects and you represent DP project teams in Technical Research and Development (TRD) sub-teams based on your strong scientific and pharmaceutical development expertise. You lead, manage and support the DP team in line with Novartis values and behaviors. You build strong team spirit and promote knowledge exchange within and between teams. You motivate and coach team members for high performance. Provide input on performance of team and team members. You formulate a sound DP project strategy incl. contingency planning and risk assessments as appropriate, involving functional experts and you ensure alignment with Pharmaceutical Development department and other departments and functions inside and outside of TRD and 3rd parties as appropriate. You assess, consolidate and negotiate resource needs and timelines for assigned projects within the DP project team and ensure resources are accurately reflected in the planning systems. You ensure adherence to the scientific and project review process and through relevant scientific and project management governance boards You ensure creation of high quality and scientific sound DP development documents enabling a strong CMC submission package and act as author, reviewer or approver role for development documents in accordance with the operational procedures and guidelines. You contribute to the generation of filing dossiers, answer DP related questions in inspections and support Health Authority requests. You lead, manage and support the DP team in line with Novartis values and behaviors. You build strong team spirit and promote knowledge exchange within and between teams. You motivate and coach team members for high performance. What you-ll bring to the role: Advanced degree in relevant scientific field (e.g. Pharmaceutical Technology, Chemistry) Minimum 2-4 years of successful industry experience in the development of pharmaceutical formulations in a matrix organization. Successfully demonstrated expertise in a specific scientific/technical area of Biopharmaceutical sciences, understanding of physical-chemical properties of molecule and impact on in-vivo performance. Knowledge of oral biopharmaceutics, biopharmaceutical modeling and defining bridging strategies is desirable. Strong project management skills, ability to solve complex problems in a matrix system with good communication, organizational, planning and negotiation skills (German language skills desired). Interdisciplinary thinking and interest in collaboration with other functions. Broad and profound understanding of development activities and processes in pharmaceutical sciences. Good knowledge of laboratory and/or technical tools as well as knowledge of relevant GLP, GMP regulations and policies. Strong presentation skills and scientific/technical writing skills. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary As a translational medicine expert (TME), you provide medical and scientific expertise and leadership to: • Drive success of early global programs, develop and implement strategies to transition to late-stage development. • Drive success of late global programs by developing and implementing strategies, which lead to clinical pharmacology and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling. • Support translational research in developing new indications, endpoints and biomarkers, using in vitro, in vivo, or in silico methods. • Provide scientific expert assessments and support for in-licensing opportunities, including due diligence About the Role This hybrid role can be based in Basel, Switzerland, or London, United Kingdom. About the role: As a Dermatology TME, you will report to the Dermatology TM Head and collaborate with other experienced TMEs in Translational Medicine Discovery & Profiling (TMDP) to develop high value decision-strategies for the Translational Medicine component of drug development projects and lead global cross-functional project teams through the early clinical phase. Job Description Key Responsibilities: Early clinical projects (Phase I / II, “Discovery”): Develop, in collaboration with other experienced TMEs, and work with teams to carry out, strategies for the Translational Medicine component of drug development projects from research to late-stage transition in single or multiple indications, including indication expansion projects. Lead global project teams through phase I/IIa to drive implementation of the development strategy. Late-stage clinical projects (“Profiling”): Act as a key leader in developing the Ph2-3 and post-approval profiling strategy for drug programs, representing TMDP on Global Project Team (GPT) along with other TM line functions. Provide support for dose selection, study design and other clinical pharmacology matters throughout the development cycle. Oversee conduct and interpretation of studies prioritized by the to support the pivotal trials. Drive analysis of studies and presents results to relevant decision boards. Be responsible for writing TM portions of documents needed for regulatory submission through drug registration. Translational Research (TR; indication seeking, endpoint and biomarker development): In collaboration with Dermatology TM Head, BR Research scientists, other TM line functions (biomarker, clinical operations, preclinical safety and pharmacokinetics) develop strategies to identify initial or expansion (indications). This may include methodology studies to identify and validate novel endpoints for early decision making in Phase IIa studies. Business Development and Licensing (BD&L; in-licensing and out licensing compounds): Participate in BD&L teams as the TM representative. Participate in teams carrying out licensing of programs, as subject matter expert for the disease indication, molecule, and clinical trial experience. General responsibilities: Responsible for clinical monitoring and integrated safety data review during and after the live phase of a study. Provides medical and scientific leadership and expertise to all line functions on the study team. Represent clinical Translational Medicine aspects to Health Authorities and other stakeholders (e.g. payers, patient advocacy groups). Oversee publication strategy for TM studies; lead writing of scientific publications; present study results externally where appropriate. Lead study-specific teams/ clinical trial teams in partnership with other line functions and collaborate closely with other TM (especially clinical operations) and non-TM (especially Project Management) line functions to ensure operational excellence, continued urgency, and close attention to timelines, costs, and subject burden in balance with high scientific standards and innovation. Essential Requirements: This position will be located at the Cambridge, MA, London, UK or Basel, Switzerland site and will not have the ability to be located remotely. This position will require approximately 7% travel as defined by the business (domestic and/ or international). This is a dual posting*. The final level and title of the offer role would be determined by the hiring team based on the skills, experience, and capabilities required to perform the role at the level the role has been offered (Associate Director / Director). Doctoral degree, MD required with clinical subspecialty training in dermatological diseases; Additional PhD/post-doctoral equivalent research and relevant Board certification preferred. Associate Director Level: 1-2 years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; Director Level: 5+ years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience. Recognized medical expertise, as evidenced by publication of significant contributions to a field over time. Excellent written and oral communication/presentation skills. Independence: Able to work independently as outlined above, commensurate with the level of the role. Innovation: Seeks out new clinical discovery opportunities and approaches to accelerate programs. Leadership of Collaborations: Able to lead multidisciplinary teams in a matrix organization. Team player mentality and willingness to collaborate and interact with the other TMEs. Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10059999 Oct 06, 2025 Switzerland Summary As a translational medicine expert (TME), you provide medical and scientific expertise and leadership to: Drive success of early global programs, develop and implement strategies to transition to late-stage development. Drive success of late global programs by developing and implementing strategies, which lead to clinical pharmacology and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling. Support translational research in developing new indications, endpoints and biomarkers, using in vitro, in vivo, or in silico methods. Provide scientific expert assessments and support for in-licensing opportunities, including due diligence About the Role This hybrid role can be based in Basel, Switzerland, or London, United Kingdom. About the role: As a Dermatology TME, you will report to the Dermatology TM Head and collaborate with other experienced TMEs in Translational Medicine Discovery & Profiling (TMDP) to develop high value decision-strategies for the Translational Medicine component of drug development projects and lead global cross-functional project teams through the early clinical phase. Job Description Key Responsibilities: Early clinical projects (Phase I / II, -Discovery-): Develop, in collaboration with other experienced TMEs, and work with teams to carry out, strategies for the Translational Medicine component of drug development projects from research to late-stage transition in single or multiple indications, including indication expansion projects. Lead global project teams through phase I/IIa to drive implementation of the development strategy. Late-stage clinical projects (-Profiling-): Act as a key leader in developing the Ph2-3 and post-approval profiling strategy for drug programs, representing TMDP on Global Project Team (GPT) along with other TM line functions. Provide support for dose selection, study design and other clinical pharmacology matters throughout the development cycle. Oversee conduct and interpretation of studies prioritized by the to support the pivotal trials. Drive analysis of studies and presents results to relevant decision boards. Be responsible for writing TM portions of documents needed for regulatory submission through drug registration. Translational Research (TR; indication seeking, endpoint and biomarker development): In collaboration with Dermatology TM Head, BR Research scientists, other TM line functions (biomarker, clinical operations, preclinical safety and pharmacokinetics) develop strategies to identify initial or expansion (indications). This may include methodology studies to identify and validate novel endpoints for early decision making in Phase IIa studies. Business Development and Licensing (BD&L; in-licensing and out licensing compounds): Participate in BD&L teams as the TM representative. Participate in teams carrying out licensing of programs, as subject matter expert for the disease indication, molecule, and clinical trial experience. General responsibilities: Responsible for clinical monitoring and integrated safety data review during and after the live phase of a study. Provides medical and scientific leadership and expertise to all line functions on the study team. Represent clinical Translational Medicine aspects to Health Authorities and other stakeholders (e.g. payers, patient advocacy groups). Oversee publication strategy for TM studies; lead writing of scientific publications; present study results externally where appropriate. Lead study-specific teams/ clinical trial teams in partnership with other line functions and collaborate closely with other TM (especially clinical operations) and non-TM (especially Project Management) line functions to ensure operational excellence, continued urgency, and close attention to timelines, costs, and subject burden in balance with high scientific standards and innovation. Essential Requirements: This position will be located at the Cambridge, MA, London, UK or Basel, Switzerland site and will not have the ability to be located remotely. This position will require approximately 7% travel as defined by the business (domestic and/ or international). This is a dual posting*. The final level and title of the offer role would be determined by the hiring team based on the skills, experience, and capabilities required to perform the role at the level the role has been offered (Associate Director / Director). Doctoral degree, MD required with clinical subspecialty training in dermatological diseases; Additional PhD/post-doctoral equivalent research and relevant Board certification preferred. Associate Director Level: 1-2 years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; Director Level: 5+ years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience. Recognized medical expertise, as evidenced by publication of significant contributions to a field over time. Excellent written and oral communication/presentation skills. Independence: Able to work independently as outlined above, commensurate with the level of the role. Innovation: Seeks out new clinical discovery opportunities and approaches to accelerate programs. Leadership of Collaborations: Able to lead multidisciplinary teams in a matrix organization. Team player mentality and willingness to collaborate and interact with the other TMEs. Why Novartis? Our purpose is to reimagine medicine to improve and extend people-s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture&nbsp ; You-ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network (link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Alternative Location 1 London (The Westworks), United Kingdom Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary Der CBC Equipment Specialist ist verantwortlich für den GMP-konformen Herstellungsprozess von Zellbanken im Basel Cell Bank Center. Ausführung der zugewiesenen Aufgaben und Tätigkeiten in der biopharmazeutischen Produktion unter Einhaltung der relevanten GMP-, Arbeitssicherheits- und Umweltrichtlinien. Operative Routinetätigkeiten um den Herstellprozess fachgerecht durchzuführen und die zeitgerechte Bereitstellung von Wirkstoff in korrekter Qualität und Quantität zu ermöglichen. About the Role Major Accountabilities Teilnahme an den Herstellungsprozessen Durchführung aller notwendigen Verarbeitungsschritte des Zellbankwesens mit höchstemKenntnisstand der aseptischen/niedrigen Keimbelastungstechnik (Auftauen, Zellpassage,Zellzählung und Einfrieren der Zellbank) Ausführung sämtlich zugewiesener Tätigkeiten gemäß dem Produktionsplan und der gültigenGMP-, Arbeits-,Betriebs-, Umwelt- und Sicherheitsanweisungen und -richtlinien Ordentliche und rechtzeitige Reinigung, Vorbereitung und Desinfektion der Produktionsanlagenund -räume Verantwortung für die Haushaltsführung des Produktionsbereichs (Reinigung, Ordnung, 5S, usw.) Einhaltung und Durchsetzen der Gesundheits-, Sicherheits- und Umweltregeln und -richtlinien(HSE) Anwendung und Durchsetzen der aktuellen GMP-Regeln Probenahme, Aliquotierung, Verteilung und Durchführung von prozessbegleitenden Kontrollen Exzellente Dokumentation der Maßnahmen, gemäß den GMP-Vorschriften Education: Abgeschlossene Ausbildung zum Chemie- und Pharmatechnologen, Technischer Abschluss; Universitatsabschluss (Chemieingenieurwesen, pharmazeutische Technologie, Biotechnologie, Biochemie) fur einige Technologieplattformen erwOnscht oder gleichwertige Erfahrung Languages: Grundkenntnisse in Englisch und Beherrschung der Landessprache des Standorts - German Experiences: Mindestens 2 Jahre abgeschlossene Berufserfahrung als Novartis-Gerätebediener oder (vorzugsweise) 5 Jahre in den Bereichen Chemie/Lebensmittel/Arzneimittel/ Biotechnologie/aseptische Herstellung oder Entwicklung Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Ausführung der zugewiesenen Aufgaben und Tätigkeiten in der biopharmazeutischen Produktion unter Einhaltung der relevanten GMP-, Arbeitssicherheits- und Umweltrichtlinien. Operative Routinetätigkeiten um den Herstellprozess fachgerecht durchzuführen und die zeitgerechte Bereitstellung von Wirkstoff in korrekter Qualität und Quantität zu ermöglichen. About the Role 1. Mitarbeit im biopharmazeutischen Herstellungsprozess im Schichtbetrieb 2. Ausführung aller zugewiesenen Tätigkeiten unter Einhaltung der gültigen GMP-, Arbeits-, Betriebs-, Umwelt- und Sicherheitsanweisungen und –richtlinien. 3. Anleitung von neuen Mitarbeitern während des on-the-job Trainings / Einarbeitungszeit. 4. Verantwortliche Durchführung einzelner Prozessstufen (Vorbereitung, Durchführung, Abschluss). 5. Ordnungsgemäße und zeitgerechte Reinigung, Vorbereitung und Sterilisierung der Produktionsgeräte und Produktionsräume 6. Durchführung von zugewiesenen Produktionsservicetätigkeiten (z.B. SAP-Buchungen, Dokumentenvorbereitung und –prüfung, Unterstützung bei Wartungsarbeiten) 7. Probenzug, Aliquotierung, Verteilung und Durchführung von ln-Prozesskontrollen 8. Durchführung des delegierten Umgebungsmonitorings für Reinräume und der delegierten Bemusterung von Reinstwasser und Reindampf 9. Organisation von Sofortmaßnahmen im Störungsfall, Melden von Auffälligkeiten an den Vorgesetzten 10. Ausführung aller zugewiesenen Tätigkeiten unter Einhaltung der GMP-, Arbeitssicherheits- und Umweltrichtlinien 11. Exzellente Dokumentation der Tätigkeiten gemäß GMP-Vorschriften 12. Einsatz für kontinuierliche Verbesserung 13. Ordnungsgemäßer Umgang mit biologischen und chemischen Substanzen in der Produktionsanlage 14. Bereitschaft zur kontinuierlichen Verbesserung und Schwachstellenanalyse 15. Teilnahme an allen für die Stelle relevanten Schulungen, Pflege der entsprechenden Trainingsnachweise 16. Voranbringen und Erhaltung eines HSE gerechten Umfelds: Melden von Beinahe-Unfällen Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10050183 Sep 18, 2025 Switzerland Summary Wir suchen eine/n Chemie- & Pharmatechnolog-in/en (CPT) zur Unterstützung der Abteilung Chemical & Analytical Development (CHAD) als Teil der Abteilung Global Technical R&D (TRD). In dieser Funktion bist du für die effektive Herstellung von Zwischenprodukten und Wirkstoffen gemäss Herstellvorschriften (Plant Master Procedures - PMPs) verantwortlich durch selbstständige Bedienung komplexer Prozessapparate und unter Einhaltung der SOP-, GSU- und anderer Richtlinien. Wir operieren innerhalb des Local Supply Center (LSC) für die klinische Versorgung in der Früh- und Spätphasenentwicklung in verschiedenen Modalitäten (z. B. synthetische Oligonukleotide, Peptidsynthese, klassische organische Chemiepräparate, Herstellung von Biokonjugaten). Wir bieten dir die Möglichkeit in einem dynamischen, agilen Umfeld in spannenden Projekten mit abwechslungsreichen Tätigkeiten sowie Entwicklungsmöglichkeiten zu arbeiten. About the Role Deine Verantwortlichkeiten umfassen eine Vielzahl von Aufgaben, die sicherstellen, dass die Produktionsprozesse reibungslos und effizient ablaufen. Dazu gehören: Zusammenarbeit und Interaktion mit internen Stakeholdern, um Projekte erfolgreich durchzuführen und wichtige Meilensteine sowie Qualitätsstandards einzuhalten. Kommunikation von Problemen an Teams und Linienmanagement. Anwendung gelernter Lektionen und Arbeiten gemäss vorgegebenen Richtlinien, um eine positive Arbeitsethik zu zeigen und andere positiv zu beeinflussen. Vorbereitung von Anlageketten und anderen Produktionsvariablen sowie die selbstständige Bedienung der zugewiesenen Anlagen und Systeme. Durchführung von Abfallentsorgungstätigkeiten gemäss internen und externen Vorschriften. Demontage, Reinigung und Remontage der Prozessanlageketten nach der Produktion. Aufzeichnung aller notwendigen Informationen im Batchprotokoll. Beitrag zur Reinigung und nachhaltigen Unterhalts des Betriebs. Einbringung von Ideen und Lösungsvorschlägen zur Behebung von Anlage- und Prozessfehlern sowie zur Prozess- und Sicherheitsoptimierung über interne Innovationsplatform. Beratung von weniger erfahrenen Prozesstechnikern bei der Bedienung der Anlagen, Prozessplanung, -durchführung und Anlagenreinigung. Durchführung spezieller Tätigkeiten wie analytische Prozessablaufkontrollen oder Wahrnehmung von Verantwortungen gemäss Verantwortlichkeitslisten. Was du mitbringst: Eine Ausbildung in einem logistischen, technischen oder verwandten Geschäftsbereich, idealerweise als Chemie- und Pharmatechnologe EFZ. Praktische Erfahrung in der chemischen oder pharmazeutischen Industrie als Chemie- und Pharmatechnologe EFZ. Vertrautheit mit der Arbeit mit computergestützten Steuerungssystemen sowie den GMP- und GSU-Anforderungen. Bereitschaft, in einem 3-Schicht-Modell und in einem vollständigen Schutzanzug (fremdbelüftet) bzw. in Reinraumbekleidung (bis Reinheitszone C) über längere Zeit zu arbeiten. Sehr gute Deutschkenntnisse in Wort und Schrift sowie Grundkenntnisse in Englisch. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Universal Hierarchy Node Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regulär Shift Work No

Summary ~Explorative Forschung führen, um neues Wissen und potenzielle Produkte zu erzeugen; Ideen und Pläne entwerfen, organisieren, fördern und ausführen, um die Rolle und den Beitrag der Chemie zur Entdeckung und zu chemischen Ansätzen zu stärken, um explorative Ziele bei der Produktfindung zu erreichen. Forschungsanträge entwickeln, um eine technisch Entwickelt Forschungsvorschläge, um eine technisch und wirtschaftlich solide Grundlage für die Entwicklung und Bewertung neuer oder verbesserter Produkte, synthetischer Methoden, Verfahren sowie analytischer und physikalischer Prüftechniken zu schaffen. techniques. Empfiehlt die Nutzung der Ergebnisse oder Änderungen des Arbeitsumfangs oder den Abbruch von Projekten. ~Forschungswissenschaftler II: Führt Experimente und Verfahren durch, die die Kompetenz mit einem breiten Spektrum wissenschaftlicher oder technologischer Techniken demonstrieren; führt qualitativ hochwertige Experimente durch und liefert und interpretiert Daten mit Kollegen und / oder Projektteams. ~Forscher I: Führt Experimente und Verfahren durch, die spezifische wissenschaftliche oder technische Kenntnisse und Labortechniken erfordern; liefert qualitativ hochwertige Daten, die sich auf die Arzneimittelentdeckung, Technologie und/oder frühe Entwicklungsprojekte auswirken. About the Role Your responsibilities will include but are not limited to: Plan and execute chemical syntheses of novel drug molecules (both LMW and bRo5) aided by in-silico tools and facilitated by state-of-the-art synthetic methodologies and technologies (automation, miniaturization). Initial focus will be on peptide-based vectors. The successful candidate will independently design and perform chemical syntheses of targeting vectors and conjugates, collaborating effectively within a dynamic team and following project protocols established by the program team. Experiment in a first-class laboratory infrastructure and evaluate and deploy novel synthetic technologies to progress projects. Work collaboratively in a multidisciplinary project team and integrate experimental data to develop scientific hypotheses and prioritize novel molecules for synthesis to answer key project questions. Collect appropriate characterization data (MS, HPLC, UPLC/MS) of reaction products and accurately document data in electronic laboratory journals and databases. Discuss and communicate scientific results at project/group meetings. Take over responsibilities to maintain the highest levels of laboratory safety and infrastructure. Minimum Requirements What you will bring to the role: Degree from a University or Fachhochschule (BSc, MSc or Diplom) with a strong focus on synthetic organic chemistry, or education as Lab Technician / Chemielaborant (or equivalent apprenticeship) with significant further chemistry training. A strong passion for hands-on experimentation in the laboratory with the ability to critically interpret results, build new experimental hypotheses, and take calculated risks and smart decisions. Prior knowledge of non-classical therapeutic modalities (e.g. peptides) is considered a plus. Profound knowledge of standard IT applications (e.g. E-Notebook, ChemDraw, MNOVA, software-controlled lab equipment). A mind-set of curiosity, creativity, collaboration and openness to diverse thinking, with an enthusiasm to develop yourself also beyond your current comfort zones, along with having excellent oral and written communication skills. A desire to collaborate with a highly dynamic team, discuss science and contribute to the next generation of drug molecules. An organized working style, eye for detail, flexibility and commitment to high quality *Restrictions on flexible working arrangements may apply and will be discussed at interview if applicable Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary The Clinical Development Medical Director (CDMD) is responsible for leading the strategic planning and management of the assigned clinical program(s) from an end-to-end clinical development perspective. As CDMD in the Renal TA, you will have oversight of the clinical development for the assigned programs and drive execution of the clinical development plan. In addition, you will enable an empowered organization, which can navigate in a matrix environment and adjust quickly to business needs. About the Role Major accountabilities: Your responsibilities will include, but are not limited to: Providing clinical leadership and strategic medical input for all clinical deliverables in the assigned project or section of a clinical program Leading development of clinical sections of trial and program level regulatory documents Driving execution the assigned clinical program and/or clinical trial in partnership with global line functions, assigned Global Trial Directors (GTDs), and regional/country medical associates, where applicable Supporting (Senior) Global Program Clinical Head (GPCH) in ensuring overall safety of the molecule for the assigned section, and may act as a core member of the Safety Management Team (SMT), supporting overall program safety reporting in collaboration with Patient Safety colleagues Supporting the Clinical Development Head (CDH) by providing medical input into Clinical Development Plan (CDP), Integrated Development Plan (IDP) and Clinical Trial Protocol (CTP) reviews, and contributing to/driving development of disease clinical standards for new disease areas As a medical expert, supporting the (Sr.) GPCH or CDH in interactions with external and internal stakeholders and decision boards May work with NIBR (Novartis Institute of Biomedical Research/ Translational Medical Sciences) to drive transition of pre-PoC (Proof of Concept) projects to DDP (Development Decision Point) and with BD&L (Business Development & Licensing) including target identification and due diligences together with other medical matters, as needed. Minimum Requirements: MD or equivalent medical degree is required in addition to advanced knowledge and clinical training in medical/scientific area; Clinical practice experience 4 years (including residency) and board certification or eligibility in disease area preferred Minimum of 7 years of experience in clinical research or drug development (Senior 10 + years plus) Experience in an academic clinical research or industry environment spanning clinical activities in Phases I through IV required. • 2 years of contribution to and accomplishment in all aspects of conducting clinical trials (e.g., planning, executing, reporting and publishing) in a global/matrix environment in pharmaceutical industry required. Working knowledge of disease area is required, with proven ability to interpret, discuss and present efficacy and safety data relating to clinical trial(s) and proven ability to understand and interpret basic and clinical scientific research reports Demonstrated ability to establish effective scientific partnerships with key stakeholders Working knowledge of GCP, clinical trial design, statistics, and regulatory and clinical development processes Previous global people management experience is preferred, though this may include management in a matrix environment. Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10063048 Sep 30, 2025 Switzerland Summary The Associate Director, Statistical Programming , is responsible for all statistical programming aspects of one or more drug development programs or indication programs with Early Development space. As a program lead, the Associate Director ensures cross-functional collaboration within and outside AQS and decision-making for assigned trials/programs in drug life cycle management. They ensure that the assigned trials/programs are adequately resourced, and oversee all aspects of programming, quality and regulatory compliance. This key leadership position ensures the efficient execution of trial/program level plans, delivering high-quality results on time. A thorough understanding of the drug development process, experience in regulatory activities, and expertise in statistical reporting, along with a proven track record in operational or functional leadership, is required. About the Role Major accountabilities: Lead SP activities for multiple clinical trials within a program or an indication /disease area. Experience in one of the TA areas: Immunology, Cardiovascular & Metabolic Diseases and Neuroscience is must. Coordinate activities of internal / external programmers. Make statistical programming decisions and propose strategies at program or indication/disease level. Develop scientific documentation for the program(s) or indication/disease area together with the Biostatistician(s). Responsible for allocating resources within a program and ensuring resource sharing between programs to meet Advanced Quantitative Science and organizational goals. Recruit, mentor, and nurture statistical programmers. Conduct performance appraisal of direct reports, as applicable. Build and maintain effective working relationships with cross-functional team members within the clinical trial/program, and able to summarize and discuss status of deliverables and critical programming aspects with them (timelines, scope, resource plan). Maintain up-to-date advanced knowledge of programming software (e.g. SAS/R) as well as industry requirements (e.g. CDISC, eCTD, Define.xml), attend functional meetings and training. Represent SP (Early Development) at indication or program-level, in audits/inspections and Health Authority (HA) meetings, and on technical programming aspects in external conferences or consortiums (e.g. CDISC) Minimum Requirements: In-depth understanding of clinical trials methodology, regulatory requirements, and Good Clinical Practice (GCP). Demonstrated leadership, collaboration, and organizational skills with the ability to successfully manage and oversee multiple trials simultaneously, ensuring deadlines are met. BS/MS degree in life science, computer science, statistics, mathematics, or equivalent relevant degree. Must also be fluent in English Must have early development experience, ideally in Oncology Excellent interpersonal skills with a proven ability to operate effectively in a global environment, influencing and communicating across functions and with external stakeholders. Expert in SAS or R programming, including the development and validation of deliverables within a Statistical Programming environment, and the creation of advanced MACROs and/or functions. Matrix or people management of approximately 6-15 internal or external programmers. Depending on role, may act as a functional/operational manager of associates or may be an individual contributor with no direct reports. Advanced knowledge of industry standards, including CDISC standards, and a solid understanding of the development and use of standard programs. At least 2+ years of experience as a Lead/Program/Project Programmer for one or more programs/indications, including the coordination of large teams of internal and/or external programmers. Ideally, 10+ years of industry experience, with at least 6 years in a programming or statistical role. At least 3 years of line management or equivalent leadership experience, such as matrix management (applicable for people managers only). Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary Novartis is seeking passionate individuals to join our innovative team. You will work with cutting-edge technology, collaborate with experts, and drive excellence in patient safety. If you're eager to advance your career and be part of a forward-thinking company, we want you on our team! About the Role **There are 2 GPSL positions available** Key Responsibilities: Safety Input and Team Participation: Provide expert safety input to the clinical development program for assigned projects/products and actively participate in the Global Program Team (GPT), Global Clinical Team (GCT), and Clinical Trial Team (CTT). Lead the Safety Management Team (SMT). Responsible for managing safety issues from the formation of the GPT through Life Cycle Management. Safety Strategy Preparation: Own the projects/products safety strategy and lead the production of medical safety deliverables. Core Global Labelling: Responsible for initial development and ongoing maintenance of safety information in Core Data Sheet, addressing safety issues in all project/product indications. Signal Detection and Safety Management: Oversee overall signal detection, monitoring, evaluation, interpretation, and appropriate management of safety information, based on data from all relevant sources. Regulatory and Professional Inquiries: Lead the preparation of the safety strategy for health authority responses and collaborate with other project team members. Respond to inquiries from regulatory authorities or healthcare professionals regarding safety issues. Departmental and Functional Goals: Contribute to and often lead the development of departmental and functional/business unit goals and objectives. Proactively engages in the development of competencies across the Medical Safety Function Role Requirements: Medical Degree or equivalent is preferred; PhD, PharmD or equivalent graduate level health care professional degree required 3 years clinical experience postdoctoral Minimum 5 years’ experience in drug development in a major pharmaceutical company (of which 2 years in a global position), including 2 years in safety at an operational or medical position. Experience in clinical trial methodology, regulatory requirements, scientific methodology, statistics and writing of publications Expertise in preparing or contributing to preparation of clinical safety assessments and regulatory reports/submissions involving safety information Experience with (safety or others) issue management Experience in leading cross-functional, multicultural teams Languages : Fluent English (both spoken and written) is mandatory. Additional Desirable Skills: Additional languages are desirable Oncology experience would be an advantage Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10061877 Sep 16, 2025 Switzerland Summary The Next Generation Scientist Program is an intensive internship program for talented and motivated research scientists from low- and middle-income countries. The 3-month program (01 June to 31 August 2026), hosted at our research site in Basel, Switzerland, is designed to foster both their scientific and professional development and consists of classroom sessions, group work assignments and active individual contribution. Guided by Novartis mentors, the interns work on a jointly agreed upon, pre-competitive scientific or clinical research project. Additionally, they learn about the pharmaceutical drug discovery and development process as well as participate in a leadership development program designed to enhance decision-making and communication skills. The internship program is run jointly by Novartis and the University of Basel. The Next Generation Scientist Program aims to build scientific and leadership capability in low- and middle-income countries by enhancing the skills of local scientists and by facilitating the knowledge transfer to their wider scientific communities upon their return home. An internship is possible in any of the broad range of therapeutic areas in which Novartis is involved; scientists with background and interest in malaria, dengue, cryptosporidiosis, visceral leishmaniasis, leprosy, sickle cell disease or Chagas disease are encouraged to apply. About the Role Duration and dates: 12-week program from 01 June to 31 August 2026; onsite Basel Campus, Switzerland Application : Please make sure to add the following documents to your application, combined in one PDF file : CV or résumé Letter of recommendation/support from a faculty member Letter of motivation how the program will benefit you Research question of interest Current MSc or PhD research proposal Academic transcripts/grade reports Minimum requirements: Enrolled at university as MSc, PhD or MD student in a geography of scope (low- and middle-income country) Preferred field of studies: Natural and Pharmaceutical Sciences, Medicine, and related fields of study Research background in malaria, dengue, cryptosporidiosis, visceral leishmaniasis, leprosy, sickle cell disease or Chagas disease preferred Active participation in all program and training activities expected Good verbal and written English communication skills Ability to work independently and in groups Time management and good organizational skills Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Corporate Affairs Business Unit Universal Hierarchy Node Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Others Job Type Full time Employment Type Early Career (Fixed Term) Shift Work No

Job ID REQ-10060551 Sep 16, 2025 Switzerland Summary To provide strategic, medical and scientific guidance and leadership for the development of multiple experimental agents in the Translational Clinical Oncology (TCO) portfolio beginning with input to early Target identification and continuing through to the Transition Decision Point. Formulate actionable development plans with the Development Organization to ensure rapid and seamless decision making and transitions of portfolio molecules and other assets. Provide scientific and clinical leadership to inform potential external innovative programs and business development in strategic areas of focus for the company. About the Role Key Responsibilities: Serve as an Early Clinical Development Area Leader for TCO, overseeing and implementing innovative clinical strategies for multiple molecules/assets that are advancing clinical testing in strategic indications, ensuring that robust and comprehensive development plans are in place and implemented. Oversee physicians (including direct reports and others) with strong mentorship and attention to ensure the strategic and operational aspects of their programs align with the overall oncology strategy and to foster their career development. Represent TCO programs and program strategy at governance boards in BR (e.g., TCO-Leadership Team (LT), Integrated Cancer Decision Board (ICDB), Discovery & Translational Board (DTB) and across the organization (e.g., Oncology Development Unit (ODU-LT), Therapeutic Area Leadership Team (TAL). Provide senior leadership and clinical input to clinical studies and pre-clinical research projects under their responsibility, effectively integrating their medical knowledge with expertise of colleagues in a wide range of other disciplines (e.g., Clinical Pharmacology, Biostatistics) to optimize the clinical development strategy, including supporting subsequent registration trials. Critically review and provide constructive feedback on documents for programs and studies under supervision including but not limited to protocol, Investigators Brochures (IBs), and health authority responses. Provide strategic input on internal and external assets and portfolio areas, representing TCO in Business Development and Licensing due diligence reviews and integrations. Lead or help oversee external collaborations, partnering closely with colleagues across the company. Play leadership roles in early development committees and initiatives by actively contributing strategic advice (e.g., the Study Concept Review Board and Protocol Review Committee). Apply medical knowledge to guide the safe, ethical and efficient conduct of own trials. Strive to maintain or exceed compliance obligations for Good Clinical Practice guidelines and Novartis Standard Operating Procedures. Liaise with outside experts, investigators, and regulatory authorities in oncology early clinical development First in Human (FIH) trials and represent projects to those groups and authorities. Write and review abstracts/manuscripts for presentation/publications at internal/external meetings. Mentor and serve as an educational resource and expert within Biomedical Research (BR) and across the organization. Essential Requirements: This hybrid position will be located at the Basel campus. This position will require 20-25% travel as defined by the business (domestic and/ or international). MD degree and PhD-level basic science required (PhD not required). MD / PhD preferred. Board-certification (or equivalent expertise) in Hematology-Oncology (heme-onc). Minimum 7 years- experience leading complex global early phase hematology-oncology clinical programs from the pharma/biotech industry plus credible experience from an academic medical center. In case of no industry experience, substantially longer academic experience in translational hematology/oncology and substantial clinical study experience. Recognized as a Heme-Onc expert with a substantial record of quality scientific publications and international recognition for expertise. Interpretation of preclinical data in hematology/oncology (molecular biology, pharmacology, pharmacokinetics, and toxicology). Working knowledge of the application of PharmacoKinetics (PK) / PharmacoDynamics (PD) and biostatistics to clinical development and trials. Proven ability to analyze and interpret efficacy and safety data relating to oncology. Knowledge of Good Clinical Practices (GCP) and world-wide regulatory requirements relating to clinical trials and oncology. Excellent medical/scientific writing and oral communication/presentation skills. Proven ability to manage and develop a team. Outstanding scientific mentor; inspires others. Excellent personal ethical integrity and commitment to improving outcomes for patients with malignancies. #LI-hybrid Why Novartis? Our purpose is to reimagine medicine to improve and extend people-s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture&nbsp ; You-ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary We are seeking a highly motivated Associate Director of Biostatistics; you will be required to influence and drive the statistical strategy and innovation through strong collaborations and decision making for assigned trials/programs within (early/full) clinical development and/or medical affairs. Proven experience in execution and analysis of complex clinical trials and leading strategy through collaborations with partners across the organization. About the Role Our Development Team is guided by our purpose: to reimagine medicine to improve and extend people’s lives. To do this, we are optimizing and strengthening our processes and ways of working. We are investing in new technologies and building specific therapeutic areas and platform depth and capabilities – all to bring our medicines to patients even faster. We are seeking key talents, like you, to join us and help give people with disease and their families a brighter future to look forward to. Apply today and welcome to where we thrive together! The Role: We are seeking a highly motivated Associate Director of Biostatistics; you will be required to influence and drive the statistical strategy and innovation through strong collaborations and decision making for assigned trials/programs within (early/full) clinical development and/or medical affairs. Proven experience in designing, and analyzing complex clinical trials and leading strategies through collaborations with partners across the organization and depending on the role, supporting regulatory submissions including planning, analysis and reporting of clinical safety and efficacy summaries as well as interacting with Health Authorities. Representing the Advanced Quantitative Sciences function both internally and externally on decision boards, developing and mentoring other statisticians, and providing solutions to the organization. This role may be in Early Development, Full Development (Oncology, Immunology, Cardio-Renal Metabolic or Neuroscience) Global Medical Affairs Key requirements: Responsible for all statistical tasks on assigned clinical trials and perform these tasks for high complexity trials with a high level of independence seeking peer input/review as required. Responsible for protocol development in alignment with the development plan, developing statistical analysis plan, and reporting activities. Contribute to planning and execution of exploratory analyses, innovative analyses related to publications and pricing & reimbursement submission and/or PK, PK/PD analyses, exploratory biomarker and diagnostic analyses, and statistical consultation. Initiate, drive, and implement novel methods and innovative trial designs and dose-finding strategies in alignment with the Lead Statistician. Experience in providing statistical expertise to support submission activities, including documents, meetings with and responses to Health Authorities, pricing agencies and drug development activities, as required. Independently lead interactions with external review boards/ethics committees, external consultants, and other external parties with oversight as appropriate. Represent Novartis in statistical discussions at external congresses, conferences, scientific meetings. Represent the Advanced Quantitative Sciences Line Function on cross-functional teams for the assigned trials. Responsible for functional alignment and ensuring line function awareness throughout the trials. Collaborate with other line functions. Explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications and interpretation of analysis results for actions/decisions/statements, when required. Establish and maintain sound working relationships and effective communication within the clinical trial team and the Advanced Quantitative Sciences team. Independent oversight of Biostatistics resources and deliverables for assigned trials. Ensure timeliness and adequate quality of all Biostatistics deliverables for the assigned trials and/or non-clinical related activities. Your Experience: MS Statistics with work experience or PhD (in Statistics or equivalent) with work experience Fluent in English with strong communication and presentation skills, with the ability to articulate complex concepts to diverse audiences. Effective utilization of innovative statistics and quantitative analytics to influence assigned program team decisions and support department to deliver objectives. Proven knowledge and expertise in statistics and its application to clinical trials. Depending on the assignment, it may require proven expertise in pharmacokinetics, exposure-response modelling, exploratory biomarker, diagnostic analyses, applied Bayesian statistics, or data exploration skills. Demonstrated excellence in use of statistical software packages (e.g. SAS, R). Strong knowledge of drug development and Health Authority guidelines. Experience in independently leading a multidisciplinary team to achieve team objectives. Expert skills to facilitate and maximize the contribution of quantitative team. Hands-on experience in leading the interface to regulatory agencies/leading the early clinical development campaign. Strong understanding of Development Unit /Therapeutic Area and or regulatory activities(depending on the role: Oncology, Immunology and Cardio Renal Metabolic) and or regulatory activities. Expert scientific leadership skills demonstrated in facilitating and optimizing the (pre/early/full-) clinical development strategy. Strong track record for global scientific leadership in the development and evaluation of modern program/trial design methodologies. Demonstrated strong skills in building partnerships and collaborations. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10062884 Oct 02, 2025 Switzerland Summary We are seeking a highly motivated Associate Director of Biostatistics; you will be required to influence and drive the statistical strategy and innovation through strong collaborations and decision making for assigned trials/programs within (early/full) clinical development and/or medical affairs. Proven experience in execution and analysis of complex clinical trials and leading strategy through collaborations with partners across the organization. About the Role Our Development Team is guided by our purpose: to reimagine medicine to improve and extend people-s lives. To do this, we are optimizing and strengthening our processes and ways of working. We are investing in new technologies and building specific therapeutic areas and platform depth and capabilities - all to bring our medicines to patients even faster. We are seeking key talents, like you, to join us and help give people with disease and their families a brighter future to look forward to. Apply today and welcome to where we thrive together! The Role: We are seeking a highly motivated Associate Director of Biostatistics; you will be required to influence and drive the statistical strategy and innovation through strong collaborations and decision making for assigned trials/programs within (early/full) clinical development and/or medical affairs. Proven experience in designing, and analyzing complex clinical trials and leading strategies through collaborations with partners across the organization and depending on the role, supporting regulatory submissions including planning, analysis and reporting of clinical safety and efficacy summaries as well as interacting with Health Authorities. Representing the Advanced Quantitative Sciences function both internally and externally on decision boards, developing and mentoring other statisticians, and providing solutions to the organization. This role may be in Early Development, Full Development (Oncology, Immunology, Cardio-Renal Metabolic or Neuroscience) Global Medical Affairs Key requirements: Responsible for all statistical tasks on assigned clinical trials and perform these tasks for high complexity trials with a high level of independence seeking peer input/review as required. Responsible for protocol development in alignment with the development plan, developing statistical analysis plan, and reporting activities. Contribute to planning and execution of exploratory analyses, innovative analyses related to publications and pricing & reimbursement submission and/or PK, PK/PD analyses, exploratory biomarker and diagnostic analyses, and statistical consultation. Initiate, drive, and implement novel methods and innovative trial designs and dose-finding strategies in alignment with the Lead Statistician. Experience in providing statistical expertise to support submission activities, including documents, meetings with and responses to Health Authorities, pricing agencies and drug development activities, as required. Independently lead interactions with external review boards/ethics committees, external consultants, and other external parties with oversight as appropriate. Represent Novartis in statistical discussions at external congresses, conferences, scientific meetings. Represent the Advanced Quantitative Sciences Line Function on cross-functional teams for the assigned trials. Responsible for functional alignment and ensuring line function awareness throughout the trials. Collaborate with other line functions. Explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications and interpretation of analysis results for actions/decisions/statements, when required. Establish and maintain sound working relationships and effective communication within the clinical trial team and the Advanced Quantitative Sciences team. Independent oversight of Biostatistics resources and deliverables for assigned trials. Ensure timeliness and adequate quality of all Biostatistics deliverables for the assigned trials and/or non-clinical related activities. Your Experience: MS Statistics with work experience or PhD (in Statistics or equivalent) with work experience Fluent in English with strong communication and presentation skills, with the ability to articulate complex concepts to diverse audiences. Effective utilization of innovative statistics and quantitative analytics to influence assigned program team decisions and support department to deliver objectives. Proven knowledge and expertise in statistics and its application to clinical trials. Depending on the assignment, it may require proven expertise in pharmacokinetics, exposure-response modelling, exploratory biomarker, diagnostic analyses, applied Bayesian statistics, or data exploration skills. Demonstrated excellence in use of statistical software packages (e.g. SAS, R). Strong knowledge of drug development and Health Authority guidelines. Experience in independently leading a multidisciplinary team to achieve team objectives. Expert skills to facilitate and maximize the contribution of quantitative team. Hands-on experience in leading the interface to regulatory agencies/leading the early clinical development campaign. Strong understanding of Development Unit /Therapeutic Area and or regulatory activities(depending on the role: Oncology, Immunology and Cardio Renal Metabolic) and or regulatory activities. Expert scientific leadership skills demonstrated in facilitating and optimizing the (pre/early/full-) clinical development strategy. Strong track record for global scientific leadership in the development and evaluation of modern program/trial design methodologies. Demonstrated strong skills in building partnerships and collaborations. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary In this role you will be accountable for establishing, leading, and continuously developing the TRD QA Sterile Operations Network to ensure phase-appropriate, best-in-class sterile standards, knowledge sharing, and cross-functional collaboration that drive quality, compliance, and innovation across all modalities About the Role Establish, lead, and continuously develop the TRD QA Sterile Operations Network, fostering accountability, learning, and collaboration. Provide specialist knowledge and guidance on sterile and low bioburden processes, ensuring compliance with regulatory requirements. Implement, harmonize, and continuously improve aseptic standards and best practices across TRD pilot plants and all modalities (Cell and Gene Therapies, Radioligand Therapies, ADC, and New Biological Entities). Drive continuous improvement, knowledge transfer, and innovation in sterility assurance. Act as a key partner in cross-functional projects, troubleshooting issues and aligning stakeholders on pragmatic solutions and standards. Mentor and develop members of the TRD QA Sterile Operations Network, addressing critical skills gaps. Consult on the evaluation and selection of external contractors for aseptic appropriateness, ensuring integrity of outsourced processes. Desired skills: Influence without authority in a matrix environment—build credibility, align stakeholders, and drive standards adoption. Proactive relationship-building—actively engage cross-functional partners to create momentum for change. Pragmatic risk-taking—balance diligence with smart, solution-oriented decision-making. Advanced problem-solving—lead troubleshooting and resolution across departmental boundaries. Effective communication—tailor messaging, negotiate, and handle pushback diplomatically. Political savvy—navigate informal networks and overcome barriers to secure a seat at the table. Qualifications Advanced degree (PhD, MSc, or equivalent) in life sciences, pharmacy, or related field Extensive experience in sterile manufacturing, quality assurance, or related areas within the pharmaceutical/biotech industry Strong knowledge of aseptic processing, sterility assurance, and regulatory requirements (e.g., FDA, EMA, ICH) Proven track record in leading cross-functional teams or networks, ideally in a matrix environment Demonstrated ability to influence without authority and drive change across organizational boundaries Excellent problem-solving, communication, and stakeholder management skills Fluent in English; additional languages a plus Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Job Description Summary The Senior Principal Biostatistician is responsible and accountable for all statistical work, scientific and operational, for one or more assigned clinical trials in collaboration with the clinical trial team/global clinical team (GCT). You will work independently at the clinical trial level and may lead indication-level or project- level statistical activities for a drug development project under limited supervision. You will propose and lead implementation of modern and innovative trial/experimental designs, statistical models, analysis and data exploration methodologies at the study or project level. This role may be in Early Development, Full Development (Oncology, Immunology, Cardio-Renal Metabolic or Neuroscience) Global Medical Affairs . About the Role Key requirements: Responsible for all statistical tasks on the assigned clinical trials and perform these tasks for mid- to high complexity trials independently with peer review/input as required. Responsible for protocol development in alignment with the clinical development plan, developing statistical analysis plan, study and indication-level reporting activities. Contribute to planning and execution of exploratory analyses, and/or PK, PK/PD analyses, exploratory biomarker and diagnostic analyses, and statistical consultation. Initiate, drive, and implement novel methods and innovative trial de-signs in alignment with the Lead Statistician. Explain statistical methodology and interpret analysis results. Provide statistical expertise to support submission activities and documents, significantly contributing to meetings with and responses to Health Authorities and other drug development activities, as required. Contribute to interactions with external review boards/ethics committees, ex-ternal consultants and other external parties with oversight as appropriate. Represent the Biostatistics & Pharmacometrics Line Function on cross-functional teams for the assigned trials. Responsible for functional alignment and ensuring line function awareness throughout the trials. Collaborate with other line functions. Explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications for actions/decisions/statements, when required. Establish and maintain collaborative relationships and effective communications cross - functionally within the Clinical Trial Team and Biostatistics & Pharmacometrics team. Ensure all Biostatistics deliverables for assigned clinical trials related activities are delivered in a timely manner with the highest level of quality. Propose and implement innovative designs and methods to optimize dose finding and drug development. Contribute to planning, prioritization and tracking of program level biostatistics activities and effective partnership with vendors. Your Experience: MS (in Statistics or equivalent) with relevant work experience or PhD (in Statistics or equivalent) with relevant work experience. Fluent in English with strong communication and presentation skills. Influences decisions that directly impact the trial/project and team ability to deliver objectives. Demonstrable experience in all tasks of a statistician at trial level with the ability to work independently.​Demonstrable knowledge and expertise in statistics and its application to clinical trials; ability to explain statistical designs and concepts. Depending on the assignment, it may require proven expertise in pharmacokinetics, exposure-response modelling, exploratory biomarker, diagnostic analyses, applied Bayesian statistics, or data exploration skills. Proficiency in the use of statistical software packages (e.g. SAS, R). Good knowledge of drug development and Health Authority guidelines. ​ Demonstrated efficiency working on a multidisciplinary team to achieve team objectives. Understanding of Franchise/Therapeutic Area and/r regulatory activities. Good project management and matrix leadership skills. Ability to collaborate well with non-statistical functions. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10062886 Oct 02, 2025 Switzerland Summary Job Description Summary The Senior Principal Biostatistician is responsible and accountable for all statistical work, scientific and operational, for one or more assigned clinical trials in collaboration with the clinical trial team/global clinical team (GCT). You will work independently at the clinical trial level and may lead indication-level or project- level statistical activities for a drug development project under limited supervision. You will propose and lead implementation of modern and innovative trial/experimental designs, statistical models, analysis and data exploration methodologies at the study or project level. This role may be in Early Development, Full Development (Oncology, Immunology, Cardio-Renal Metabolic or Neuroscience) Global Medical Affairs . About the Role Key requirements: Responsible for all statistical tasks on the assigned clinical trials and perform these tasks for mid- to high complexity trials independently with peer review/input as required. Responsible for protocol development in alignment with the clinical development plan, developing statistical analysis plan, study and indication-level reporting activities. Contribute to planning and execution of exploratory analyses, and/or PK, PK/PD analyses, exploratory biomarker and diagnostic analyses, and statistical consultation. Initiate, drive, and implement novel methods and innovative trial de-signs in alignment with the Lead Statistician. Explain statistical methodology and interpret analysis results. Provide statistical expertise to support submission activities and documents, significantly contributing to meetings with and responses to Health Authorities and other drug development activities, as required. Contribute to interactions with external review boards/ethics committees, ex-ternal consultants and other external parties with oversight as appropriate. Represent the Biostatistics & Pharmacometrics Line Function on cross-functional teams for the assigned trials. Responsible for functional alignment and ensuring line function awareness throughout the trials. Collaborate with other line functions. Explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications for actions/decisions/statements, when required. Establish and maintain collaborative relationships and effective communications cross-functionally within the Clinical Trial Team and Biostatistics & Pharmacometrics team. Ensure all Biostatistics deliverables for assigned clinical trials related activities are delivered in a timely manner with the highest level of quality. Propose and implement innovative designs and methods to optimize dose finding and drug development. Contribute to planning, prioritization and tracking of program level biostatistics activities and effective partnership with vendors. Your Experience: MS (in Statistics or equivalent) with relevant work experience or PhD (in Statistics or equivalent) with relevant work experience. Fluent in English with strong communication and presentation skills. Influences decisions that directly impact the trial/project and team ability to deliver objectives. Demonstrable experience in all tasks of a statistician at trial level with the ability to work independently.Demonstrable knowledge and expertise in statistics and its application to clinical trials; ability to explain statistical designs and concepts. Depending on the assignment, it may require proven expertise in pharmacokinetics, exposure-response modelling, exploratory biomarker, diagnostic analyses, applied Bayesian statistics, or data exploration skills. Proficiency in the use of statistical software packages (e.g. SAS, R). Good knowledge of drug development and Health Authority guidelines. Demonstrated efficiency working on a multidisciplinary team to achieve team objectives. Understanding of Franchise/Therapeutic Area and/r regulatory activities. Good project management and matrix leadership skills. Ability to collaborate well with non-statistical functions. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Development Business Unit Innovative Medicines Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Research & Development Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Summary The Clinical Development Director (CDD) in the Cardio Renal & Metabolic (CRM) Development Unit is responsible for leading the strategic planning and management of the assigned clinical program(s) from an end-to-end clinical development perspective. As a CDD in the Renal TA, you will have oversight of the clinical development for the assigned programs and drive the execution of the clinical development plan. In addition, you will enable an empowered organization, which can navigate in a matrix environment and adjust quickly to business needs. About the Role Major accountabilities: • Providing clinical leadership and strategic input for all clinical deliverables in the assigned project or section of a clinical program. Clinical deliverables may include clinical sections of individual protocols or sub studies consistent with the Integrated Development Plans (IDP), clinical data review, program specific standards, clinical components of regulatory documents/registration dossiers, and publications • Leading development of clinical sections of trial and program level regulatory documents • Driving execution of the section of the clinical program in partnership with global line functions, assigned Global Trial Directors (GTDs), and regional/country medical associates, if applicable • Overseeing/conducting ongoing medical and scientific review of clinical trial data with Clinical Scientific Expert(s) with appropriate oversight from Medical Lead • Supporting (Sr.) GPCH in ensuring overall safety of the molecule for the assigned section and may be a core member of the Safety Management Team, supporting overall program safety reporting in collaboration with Patient Safety • As a clinical expert, supporting the (Sr.) GPCH or CDH in interactions with external and internal stakeholders and decision boards • Contributing to scientific training of relevant Novartis stakeholders on the disease area and compound/molecule. May serve as speaker for franchise medical/scientific training and may be the Program Manager of other associates Minimum Requirements: • Advanced degree in life sciences / healthcare (or clinically relevant degree) is required. PharmD or PhD is strongly preferred • Fluent oral and written English • Minimum 7 years experience in clinical research or drug development • Working knowledge of the assigned disease area is desired with proven ability to interpret, discuss and present efficacy and safety data relating to clinical trial(s) or program level • Demonstrated ability to establish effective working relationship with key investigators • Working knowledge of GCP, clinical trial design, statistics, and regulatory and clinical development processes • Strong communication skills with the ability to work in a cross functional and global organization Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people - and - culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits - rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary This team within Discovery Sciences at Novartis Biomedical Research is at the forefront of integrating AI-powered tools into the drug discovery pipeline. Through collaboration in multidisciplinary and cross-functional teams, we are driving the adoption of these technologies to advance early-stage drug discovery, including the development of wet lab workflows informed by computational (in-silico) results— and vice versa. If you thrive on turning scientific challenges into computational solutions that enhance data-driven drug discovery, we encourage you to apply today. As part of a global Data Science group, you will engage with experts in structural bioinformatics, computational biology, cheminformatics, and imaging. This position offers a unique opportunity to apply cutting-edge structure-based AI approaches—such as protein–ligand co-folding and peptide design—to generate meaningful impact through collaborative wet and dry lab work. About the Role Role Responsibilities Apply AI technologies to drive progress in drug discovery projects with a focus on protein biology, including protein–ligand co-folding and peptide design. Collaborate with wet-lab specialists (structural biologists, biophysicists, protein chemists) to move structure-informed drug discovery forward using innovative, AI-enabled strategies. Develop and adapt structure-based computational methodologies tailored to project objectives. Integrate proprietary data from protein crystallography, biomolecular NMR, cryo-EM, biophysics, and screening into predictive AI models. Leverage internal and external protein data resources to create impact in drug discovery. Candidate Profile PhD or equivalent experience in structural biology, bioinformatics, cheminformatics, molecular modeling, or a related scientific discipline. Must have direct experience with modern computational tools for protein and peptide design, as well as co-folding applications. Solid understanding of molecular recognition and protein-ligand binding energetics. Competence with machine learning frameworks such as PyTorch or TensorFlow. Proficiency in scripting languages (Python, R) and high-performance computing environments on Linux. Experience automating workflows and scripting for large-scale data processing. Ability to work effectively in fast-paced, innovative settings focused on solution-driven approaches. Strong communication skills, able to present complex findings clearly in both spoken and written formats. Desirable Qualifications Understanding of drug discovery and structure-based drug design. Experience with advanced machine learning techniques. Familiarity with relational databases and SQL. Experience utilizing AWS resources. Background in protein and peptide design. Expertise in structural biophysics methods. Experience working at the wet-dry lab interface. Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary The Scientific Data & Products (SDP) group in Research Informatics (RX) is driven to maximize the impact and value to BR of software and data. We deliver powerful, functional, beautiful, and integrated software solutions that create a frictionless user experience. Our organization is here to build and apply excellence in product and data management to further Novartis drug discovery. About the Role The Data Management group in Research Informatics (RX) is seeking a visionary and technically skilled Data Architect to lead the design and implementation of enterprise-scale data architectures. This role is pivotal in ensuring that biomedical research data is AI-ready, accessible, and interoperable across scientific domains. The focus is on designing robust data architectures, technical stacks, and APIs that enable seamless data integration, governance, and utilization by AI models and data scientists. Major Responsibilities - Design and evolve enterprise-level data architectures that support scientific data interoperability and AI-readiness. - Define and implement technical stacks and APIs to enable secure, scalable, and performant data access. - Establish formal data architecture processes aligned with research data management policies and FAIR principles. - Collaborate with domain experts to define logical data domains, sub-domains, and critical data elements (CDEs). - Inventory and map physical data repositories to logical domains and facilitate metadata capture at data creation. - Develop conceptual and logical data models and document relationships between data objects. - Ensure alignment with scientific standards (e.g., HELM, CDISC) and enforce metadata governance. - Promote the creation of “born FAIR” data and support the publication of CDEs to foundational platforms (e.g., data lakes, warehouses). - Collaborate with IT, data engineering, and security teams to ensure compliance, automation, and operational integration. - Drive architectural improvements and standardization across scientific data workflows. ​ Essential Requirements: - 10+ years of experience in data architecture, data engineering, or software development. - 5+ years in scientific software or drug discovery environments. - Master’s degree or equivalent experience in a relevant field. - Deep expertise in designing data architectures, APIs, and technical stacks. - Experience with RDF, ontologies, cloud platforms (AWS, Google, Azure), and graph databases. - Strong understanding of laboratory data workflows and scientific data types (biology, chemistry, clinical). - Proven ability to align scientific and IT stakeholders around strategic data initiatives. This role offers a unique opportunity to shape the future of data architecture in biomedical research and to enable transformative AI-driven insights. ​ You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary In close collaboration with the Head of Product Design Excellence (PDEx), you will play a pivotal role in advancing the competitive product design pillar of the Technical Research & Development (TRD) Strategy 2030 by evolving the PDEx framework and processes. This role requires a unique blend of commercial experience and technical understanding which bridges the gap between scientific innovation and business impact. You will act as a connector across technical and commercial, development and biomedical research teams, driving strategy, ensuring alignment and maximizing value throughout the product lifecycle across the Novartis portfolio. About the Role Drive further evolution of the enterprise-wide product design framework Lead initiatives related to the PDEx framework and processes together with leaders in TRD (e.g. technical project leadership, innovation council, TRD leadership) as well as relevant stakeholders in biomedical research, development, Strategy and Growth (S&G), Commercial etc. Further evolve PDEx as an integrative part of NVS Strategic Asset Life Cycle Management and drive asset maximization and product differentiation in line with TRD, Development and Commercial objectives. Collaborate with TRD line functions (e.g. CMC, formulation, packaging and devices) and other NVS internal organizations dealing with product design-relevant topics (e.g. Development Functions, Corporate Affairs / Patient Engagement, S&G, Commercial, Biomedical Research and TechOps) to optimize product design in a rapidly evolving environment Serve as a liaison between TRD and commercial organizations to ensure customer needs and market dynamics inform product design decisions. Translate complex technical concepts into compelling business narratives for senior leadership and cross-functional teams. Consultancy and Strategic Support . Provide consultancy to project teams (GPTs and CMC sub teams) to facilitate optimal product design outcomes and to proactive product design LCM planning and strategies. Support teams in gathering and leveraging customer and market insights on product design topics. Drive awareness of product design across the business Deputize for the Head of PDEx when required, representing the function in strategic discussions and decision-making forums. What You Will Bring: Advanced degree in Life Sciences At least 7 years at a senior level in pharmaceutical marketing, market access or medical affairs with direct experience of gathering customer insights (market research, competitive intelligence, KOL management). 10+ years' experience in Pharma. Good understanding of the CMC aspects of drug development and knowledge of product design elements including drug delivery formulations and technologies including devices Demonstrated ability to work across technical and commercial teams, bridging diverse perspectives to achieve strategic goals. Strong track record in communication, storytelling, and senior stakeholder management. Strategic thinking with the ability to connect dots across functions and anticipate future trends. Excellent interpersonal and presentation skills. Ability to thrive in a complex, technical and matrixed environment. Languages: Fluent English required (oral & written). Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary At data42, our vision is to inspire collaborative, groundbreaking data and AI initiatives that reimagine drug discovery at Novartis and accelerate time to market—ultimately transforming healthcare and improving lives. We are a dynamic team committed to this mission by enabling secondary research and data-driven decisions through scientific support and analysis-ready data, all within a secure, governed, AI-enabled platform. The Semantic Technologies Lead (Director Level) is responsible for setting the strategic vision and leading the implementation of semantics and metadata standards within data42. This role is accountable for the integrity, scalability, and impact of semantic frameworks across data42’s Pre-Clinical, Clinical, Omics, and Real-World Data pipelines, enabling disease-centric multimodal analysis and investigation. The Director ensures that all semantic initiatives within data42 are closely aligned with Novartis’s broader R&D and enterprise data strategies, while driving innovation and excellence from within the data42 organization through structured metadata and advanced ontology management (e.g., MedDRA, SDTM, ADaM, WHODrug, ISO taxonomies), driving data FAIRification and supporting sophisticated patient cohorting and analytical capabilities. In addition to overseeing the evolution of metadata systems and the data42 data catalog, this position plays a critical role in enhancing AI-driven projects and guiding the transformation of data42 into a next-generation AI-enabled program and will act as a strategic enabler of semantic technologies to unlock the full potential of multimodal and multidimensional data across the R&D and medical continuum, while maintaining strong alignment with enterprise-wide standards and objectives. About the Role Major Accountabilities Advise data42 and Novartis R&D leadership on data and AI strategy, risk, and investment, and communicate complex technical concepts to non-technical stakeholders. Manage large, cross-functional teams and budgets within data42, fostering a culture of innovation, collaboration, and high performance. Represent data42 in cross-functional and enterprise-wide working groups, standards bodies, and relevant external forums, ensuring data42’s needs and innovations are well integrated and recognized. Lead the development and deployment of AI-enabled metadata tools and knowledge graphs to facilitate data findability, semantic enrichment, and advanced analytics within data42. Champion the adoption and operationalization of FAIR data principles within data42, ensuring all data assets are properly tagged, governed, and aligned with both data42 and enterprise business and scientific objectives. Oversee the strategic evolution and governance of the data42 data catalog and metadata systems, ensuring comprehensive coverage, accessibility, and regulatory compliance of all managed data assets. Lead the design, build, and operationalization of scalable, cloud-based data and analytics platforms—including data lakes, catalogs, and ontology management solutions—within data42, supporting the full drug development lifecycle. Serve as the primary liaison between data42 and enterprise-level data and semantic governance bodies, ensuring that data42’s frameworks, standards, and tools are interoperable and consistent with company-wide objectives. Set and execute the semantic and metadata strategy for data42, ensuring all initiatives are fully aligned with the broader Novartis R&D and enterprise data strategy, while proactively fostering a culture of innovation within data42 to deliver transformative, next-generation solutions. Experience / Professional Requirements Advanced degree (PhD or equivalent) and 15+ years of progressive experience in metadata management, semantic technologies, ontology engineering, AI, and insights generation within the pharmaceutical, biotechnology, or related industry, including at least 5 years in a senior leadership role. Deep expertise in industry standards such as CDISC (SDTM, ADaM, SEND), HL7 FHIR, MedDRA, and WHODrug, with a proven track record of applying these in large-scale, complex data environments within R&D or clinical settings. Demonstrated leadership in designing, building, and operationalizing department-level or cross-functional data initiatives involving semantic technologies, ontologies, and knowledge graphs, with a focus on driving innovation and aligning with broader enterprise data strategies as the most senior semantic technologies leader within data42. Strong proficiency in FAIR data principles and their operationalization in biomedical and business contexts, with experience championing FAIR adoption within a department or program. Advanced knowledge of ontology authoring and engineering, including lifecycle management, methodologies, tools, and languages for building and maintaining ontologies at scale. Proven ability to lead and inspire multidisciplinary teams, manage budgets, and influence stakeholders at all levels, including executive and enterprise partners. Familiarity with Generative AI and Large Language Models (LLMs), with a focus on transforming unstructured and unharmonized data into actionable insights and enabling AI-driven innovation within a department or program. Expertise in Semantic Web technologies (e.g., RDF, OWL, SKOS, SPARQL) and their application to biomedical domains, including OBO Foundry ontologies. Experience serving as a liaison between a department/program and enterprise-level data governance or standards bodies, ensuring alignment and interoperability. Exceptional communication, stakeholder management, and change leadership skills. Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary The purpose of the role is to provide nonclinical regulatory toxicology expertise on R&D project teams supporting the successful initiation of clinical trials and achievement of registration for drug candidates of various modalities. The Director level Project Team Member leads cross functional associates (i.e. PCS Target Team) to develop and implement integrated nonclinical toxicology study plans, drafts regulatory responses and all required submission documentation and manages the respective project communication strategy within PCS and Novartis About the Role This hybrid role can be based in Basel or London (White City) Key Responsibilities: Leads PCS Target Teams to design, integrate and interpret results of nonclinical safety assessment program including impact to drug development and/or project timeline Represents PCS on cross functional R&D project teams to design appropriately compliant and scientifically relevant nonclinical safety package Recognize the need for a “fit for purpose and modality” nonclinical program as needed and collaborate with line functions outside of PCS to accomplish this goal Participates in internal Novartis initiatives to improve use of nonclinical/translational safety data for drug development decisions. Manages communications and builds relationships between PCS and R&D project teams Negotiates with Global Health Authorities (HA) worldwide regarding safety issues, scientific interpretation and acceptability nonclinical safety package to support clinical trials and market approval. Responsible for authoring nonclinical safety sections of internal and regulatory documents supporting clinical development and market approval May evaluate in/out-licensing opportunities and carries out technical Due Diligence activities upon request. Participates or Leads internal and/or external cross-functional groups on key initiatives focused on PCS objectives and/or current nonclinical safety topics. Mentors colleagues on drug development strategy and project-related matters Essential Requirements: Minimum of 5 years experience as a nonclinical safety Project Team member; Demonstrated experience in the preclinical development of small molecule, biotherapeutics and/or gene and cell therapies and the safety issue awareness of these modalities. 8+ years experience in a nonclinical drug development scientific discipline (e.g. study director, project team toxicologist or pharmacologist). Demonstrated experience in direct or written communication of strategy and data to global health authorities, supporting clinical development and market approval. Knowledge of drug development strategy for immunomodulatory drugs Leadership in cross-industry organizations (discipline-related or related to drug development). Excellent interpersonal, leadership, organizational skills (e.g. planning and time management) and teamwork skills. Excellent oral and written communication and influencing skills. Highly efficient, self-motivated, flexible and able to work independently and efficiently under time constraints. Ability to focus and work on several projects simultaneously and to effectively manage conflicting expectations from the line unit, TA Strategy team and project teams in a matrix management environment. Customer focused thinking. Recognized ability to represent PCS on Novartis cross functional decision boards or other cross functional project teams. Recognized expertise in technical and scientific problem solving in a project driven, multi-disciplinary international environment. Ability to mentor and coach Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network(link is external) #LI-hybrid Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary This role could be a combination of the following high level descriptions: -Responsible for all statistical programming/data review reporting & Analytics development aspects of one or more drug development projects or disease area. Direct, oversee and coordinate all activities, deliverables and resources within respective group or disease area. Ensure trials are conducted to a consistently high standard with respect to cost, quality and timelines. - Active participation in the new platform and technology enhancements/implementations in Novartis, the associate will bring his knowledge, her/his experience and expertise in statistical programming and clinical trial data, business tools and health authority requirements to ensure the SP needs are addressed. About the Role Major accountabilities: Acts as a key functional expert who manages, directs and coordinates the activities of a specific assigned area, project or team of experienced specialists -Determines methods and procedures on new projects/ assignments. Leads the decision‐making process for establishing multidisciplinary project/program goals within own team -Defines team goals, aligns and provides input to department strategy -Manages and coordinates the assignment of resources and workload within his/her group or disease area, and ensures sharing of resources between groups in order to meet departmental objectives and priorities. May act as a subject Matter Expert for key operational areas influencing respective function . Provides all necessary support to help address and resolve issues. Identifies solutions for remediation -Understands Health Authority requirements and is able to participate in Health Authority inspections as required -Leads and supports clinical and non-clinical special projects and initiatives -Reporting of technical complaints / adverse events / special case scenarios related to Novartis products within 24 hours of receipt -Distribution of marketing samples (where applicable) Minimum Requirements: In-depth understanding of clinical trials methodology, regulatory requirements, and Good Clinical Practice (GCP). Demonstrated leadership, collaboration, and organizational skills with the ability to successfully manage and oversee multiple trials simultaneously, ensuring deadlines are met. BS/MS degree in life science, computer science, statistics, mathematics, or equivalent relevant degree. Must also be fluent in English Excellent interpersonal skills with a proven ability to operate effectively in a global environment, influencing and communicating across functions and with external stakeholders. Expert in SAS or R programming, including the development and validation of deliverables within a Statistical Programming environment, and the creation of advanced MACROs and/or functions. Matrix or people management of approximately 6-15 internal or external programmers. Depending on role, may act as a functional/operational manager of associates or may be an individual contributor with no direct reports. Advanced knowledge of industry standards, including CDISC standards, and a solid understanding of the development and use of standard programs. Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Are you a highly skilled and ambitious medical professional with a passion for research? If so, we have an exceptional opportunity for you! Novartis, a world-class pharmaceutical company, is seeking a Clinical Development Medical Director - Renal to join our team in Switzerland. As a Research role, this position offers a unique chance to contribute to groundbreaking medical advancements in the field of renal medicine. About the Role Novartis is seeking a highly qualified Clinical Development Medical Director - Renal **80-100% to join our exceptional team in Switzerland or the UK. As a world-class pharmaceutical company, Novartis is dedicated to improving global health through groundbreaking research and innovative solutions. Responsibilities: Lead the clinical development activities for renal disease therapeutic area, ensuring flawless execution of clinical trials. Collaborate with cross-functional teams to design and implement clinical development plans. Provide medical expertise and guidance throughout the clinical development process. Successfully compete clinical trial protocols, investigator brochures, and informed consent forms. Determine appropriate safety monitoring and risk management strategies. Ensure compliance with all applicable regulatory and ethical guidelines. Contribute to the preparation and submission of regulatory documents. Analyze and interpret clinical trial data to support decision-making. Participate in scientific conferences and present clinical trial results. Requirements: Medical degree and experience in Nephrology or a related field. Proven experience in clinical development within the pharmaceutical or biotech industry. Strong knowledge of renal diseases and related therapies. Excellent understanding of clinical trial design and execution. Exceptional communication and interpersonal skills. Ability to work effectively in a cross-functional and multicultural environment. Strong leadership and project management abilities. Proficiency in English, both written and spoken. Novartis offers a unique opportunity for a CDMD to contribute to innovative research and make a significant impact on patients' lives. Joining our team means working with individuals who demonstrate exceptional problem-solving skills and a dedication to collaborative work in a dynamic and driven environment. At Novartis we are committed to fostering diversity and inclusion. We are an equal opportunity employer (EOE) and value the contributions of individuals from all backgrounds. We strive to provide a work environment that promotes fairness, respect, and equal opportunities for growth and development. We also understand the importance of reasonable accommodations and adjustments for individuals with disabilities. If you require any accommodations or adjustments throughout the application process, please let us know, and we will ensure that your needs are met. Join a leading organization committed to revolutionizing healthcare through advanced research and inventive solutions. Apply today and contribute to our impactful work! Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland #onsite (*please note that we will consider applicants at both Senior Expert & Associate Director level, depending on the level of experience) Role Purpose: Novartis holds a rich development portfolio of small molecules ready to develop into innovative patient centric oral dosage forms. As a Drug Product Project Leader working on oral dosage forms, you will lead and manage formulation and manufacturing activities linked to pharmaceutical development for small molecules (New Chemical Entities; NCE) for assigned projects. For this position, specific emphasis lies on bringing in-depth experience in applied data science, mechanistic modelling and simulation of pharmaceutical unit operations. You will lead drug product teams during all stages of development but with a focus on initial clinical phases. You will be working on oral Small Molecules and in particular on enabling formulation approaches. You will use your strong communication and influencing skills to effectively lead the drug product subteam. Your expertise will facilitate the creation of innovative and stable drug products suitable for human trials and commercial supplies. About the Role Your responsibilities will include but are not limited to: You lead and manage all Drug Product (DP) related technical development activities for assigned projects and you represent DP project teams in Technical Research and Development (TRD) sub-teams based on your strong scientific and pharmaceutical development expertise. You lead, manage and support the DP team in line with Novartis values and behaviors. You build strong team spirit and promote knowledge exchange within and between teams. You motivate and coach team members for high performance. Provide input on performance of team and team members. You formulate a sound DP project strategy incl. contingency planning and risk assessments as appropriate, involving functional experts and you ensure alignment with Pharmaceutical Development department and other departments and functions inside and outside of TRD and 3rd parties as appropriate. You assess, consolidate and negotiate resource needs and timelines for assigned projects within the DP project team and ensure resources are accurately reflected in the planning systems. You ensure adherence to the scientific and project review process and through relevant scientific and project management governance boards You ensure creation of high quality and scientific sound DP development documents enabling a strong CMC submission package and act as author, reviewer or approver role for development documents in accordance with the operational procedures and guidelines. You contribute to the generation of filing dossiers, answer DP related questions in inspections and support Health Authority requests. You lead, manage and support the DP team in line with Novartis values and behaviors. You build strong team spirit and promote knowledge exchange within and between teams. You motivate and coach team members for high performance. What you’ll bring to the role: Advanced degree in relevant scientific field (e.g. Pharmaceutical Technology, Chemistry) Minimum 2-4 years of successful industry experience in the development of pharmaceutical formulations in a matrix organization. Successfully demonstrated expertise in a specific scientific/technical area of Biopharmaceutical sciences, understanding of physical-chemical properties of molecule and impact on in-vivo performance. Knowledge of oral biopharmaceutics, biopharmaceutical modeling and defining bridging strategies is desirable. Strong project management skills, ability to solve complex problems in a matrix system with good communication, organizational, planning and negotiation skills (German language skills desired). Interdisciplinary thinking and interest in collaboration with other functions. Broad and profound understanding of development activities and processes in pharmaceutical sciences. Good knowledge of laboratory and/or technical tools as well as knowledge of relevant GLP, GMP regulations and policies. Strong presentation skills and scientific/technical writing skills. Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Accessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary We are offering a 6-month legal trainee position starting January 2026 to support the Novartis Procurement, Data/Digital &IT Legal department on a wide range of legal matters and projects in areas such as contract law, commercial law, antitrust law, intellectual property and disputes/litigation. About the Role We are offering a 6-month legal trainee position starting January 2026 to support the Novartis Procurement, Data/Digital &IT Legal department on a wide range of legal matters and projects in areas such as contract law, commercial law, antitrust law, intellectual property and disputes/litigation. This legal trainee position offers excellent opportunities to gain first-class, hands-on in-house legal experience within the stimulating, multinational environment of a leading pharmaceutical company. Duration: 6 months Start: January 1, 2026 Your responsibilities will include: • Support a diverse range of commercial matters relating to direct and indirect procurement, manufacturing, IT • Support diverse range of legal projects, e.g. contract templates, legal trainings, global legal research projects, digitalization, outsourcing, etc. • Assist with the drafting, negotiation and review of a variety of transactional, commercial and agreements • Draft legal memoranda on a wide variety of legal issues and disputes, Draft document and key position summaries • Provide legal advice to internal clients • You will be supervised and guided by a range of lawyers on different levels of the company, ensuring a great learning experience What you’ll bring to the role: Essential: • Swiss Law degree (Master of Law and Bachelor of Law has to be on Swiss Law), master's degree needs to be completed before start date • Business-level English skills (written and spoken), additional language is a plus • Interest in legal topics in a large multinational group of companies • High motivation to perform, to discover and learn new things and ability to work independently Desirable requirements: • Prior legal professional experience in a law firm, court or legal in-house department (internships etc.) would be helpful. We are also open to applicants without prior experience who have a strong interest and are motivated to learn on the job • Other professional experience in the corporate environment is a plus Please submit a cover letter that includes your motivation for the position and your availability to start in January 2026. Thank you. Why Novartis Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben , and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary The Next Generation Scientist Program is an intensive internship program for talented and motivated research scientists from low- and middle-income countries. The 3-month program (01 June to 31 August 2026), hosted at our research site in Basel, Switzerland, is designed to foster both their scientific and professional development and consists of classroom sessions, group work assignments and active individual contribution. Guided by Novartis mentors, the interns work on a jointly agreed upon, pre-competitive scientific or clinical research project. Additionally, they learn about the pharmaceutical drug discovery and development process as well as participate in a leadership development program designed to enhance decision-making and communication skills. The internship program is run jointly by Novartis and the University of Basel. The Next Generation Scientist Program aims to build scientific and leadership capability in low- and middle-income countries by enhancing the skills of local scientists and by facilitating the knowledge transfer to their wider scientific communities upon their return home. An internship is possible in any of the broad range of therapeutic areas in which Novartis is involved; scientists with background and interest in malaria, dengue, cryptosporidiosis, visceral leishmaniasis, leprosy, sickle cell disease or Chagas disease are encouraged to apply. About the Role Duration and dates: 12-week program from 01 June to 31 August 2026; onsite Basel Campus, Switzerland Application : Please make sure to add the following documents to your application, combined in one PDF file : • CV or résumé • Letter of recommendation/support from a faculty member • Letter of motivation how the program will benefit you • Research question of interest • Current MSc or PhD research proposal • Academic transcripts/grade reports Minimum requirements: Enrolled at university as MSc, PhD or MD student in a geography of scope (low- and middle-income country) Preferred field of studies: Natural and Pharmaceutical Sciences, Medicine, and related fields of study Research background in malaria, dengue, cryptosporidiosis, visceral leishmaniasis, leprosy, sickle cell disease or Chagas disease preferred Active participation in all program and training activities expected Good verbal and written English communication skills Ability to work independently and in groups Time management and good organizational skills Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary Location: Basel, Switzerland Full time, onsite, #LI-Onsite At Novartis we are reimagining medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. We are looking for a highly motivated, passionate researcher with a strong scientific background in radiochemistry, a curious mindset, and cultural agility to work in a highly dynamic team to identify new targeting vectors for radioligand therapy (RLT) . About the Role Key Responsibilities: Radioligand synthesis: Independently plan and perform the synthesis of radioligands (including LMW compounds, peptides, and protein-based vectors) using radionuclides such as Lu-177, Ga-68, and F-18, as part of a dynamic team of radiochemists in alignment with project goals. Method development: Develop, evaluate, and validate novel radiolabeling methods and formulation strategies to optimize processes. Quality control: Conduct quality control analyses of radioligands (e.g., HPLC, TLC, SEC) and ensure their readiness for preclinical in vitro and in vivo studies. Collaborative research: Collaborate effectively with multidisciplinary teams, including organic chemists, pharmacologists and cell biologists, to advance the characterization and development of radioligand therapies (RLTs) in oncology. Innovation: Explore and implement innovative technologies, including automation, to enhance efficiency in daily tasks. Radiation Safety: Adhere to radiation safety guidelines, including training, dosimetry monitoring, and proper handling and disposal of radioactive materials. Minimum Requirements - What You’ll Bring to the Role: Scientific expertise: A strong enthusiasm for hands-on experimental chemistry and radiochemistry, with the ability to interpret results critically, formulate new hypotheses, and design subsequent steps. Education: A master’s or bachelor’s degree or equivalent apprenticeship in chemistry, pharmacy, or a related field, with prior experience in radiochemistry and radiolabeling techniques (PhD is not required). Experience: At least 1-2 years of practical experience in a radiochemistry laboratory, along with proficiency in standard IT tools (e.g., E-Notebook, ChemDraw, and software-controlled lab equipment). Team-oriented approach: Passion for working in cross-disciplinary teams, exchanging scientific ideas, contributing to shared goals and learning from colleagues with diverse perspectives to advance future RLTs Mindset: Strong organizational skills, attention to detail, flexibility, and a commitment to delivering high-quality results. Technical proficiency: Familiarity with automated synthesizers for radiolabeling and purification is an advantage. Communication skills: Good written and verbal communication skills in English. Professional Growth and Development We are committed to fostering the professional growth of every team member. In this role, you will have the opportunity to develop and expand your expertise both scientifically and technically. Scientific Involvement : You will be actively involved in project teams, where you can engage intellectually, contribute your ideas, and help shape the direction of innovative projects. Technical Growth : You will have the chance to become an expert and go-to person for specific instruments, tools, or processes, making an impactful contribution to the team. As you grow in this role, you'll take on increasingly significant responsibilities, becoming a valued contributor to our team’s success. We believe in empowering our team members to thrive through collaboration, continuous learning, and meaningful challenges. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. *Please note that restrictions on flexible working may apply and will be discussed at interview stage if applicable Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Summary In dieser Rolle übernehmen Sie die technische und wissenschaftliche Verantwortung für prozessspezifische Fragestellungen innerhalb der Produktion. Sie stellen sicher, dass alle Prozesse termingerecht und gemäß cGMP, SOPs sowie geltenden Richtlinien und Standards (z.B. HSE, NOSSCE) durchgeführt werden. Darüber hinaus tragen Sie zur kontinuierlichen Verbesserung der Qualität und Effizienz bei und sichern die Geschäftskontinuität durch Ihre Expertise und Problemlösungskompetenz. #LI-Onsite Location: Muttenz, Switzerland About the Role Ihr Aufgabenbereich: Unterstützung der Produktion bei technischen und prozessspezifischen Herausforderungen in Echtzeit Sicherstellung der GMP-konformen Durchführung und Dokumentation aller Produktionsprozesse Durchführung und Pflege von Validierungen sowie relevanter Produktionsdokumente Schulung und Weiterentwicklung der Produktionsmitarbeitenden Bearbeitung von Abweichungen, Beschwerden und Umsetzung von CAPAs Mitwirkung bei Inspektionen und Einhaltung gesetzlicher Qualitäts- und HSE-Vorgaben Leitung und Unterstützung von Projekten zur kontinuierlichen Verbesserung und Technologieübertragung Definition technischer Anforderungen und Begleitung von Investitionsprojekten Förderung der Qualitäts- und HSE-Kultur am Standort Ihr Anfoderungsprofil: MSc oder PhD in organischer Chemie Mindestens zwei Jahre Erfahrung in der pharmazeutischen Industrie und in der Produktion Sehr gute Deutsch- und Englischkenntnisse Optional: Erfahrung mit Oligonukleotiden (z.B. siRNA) Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive working environment and diverse teams, representative of the patients and communities we serve. Accessibility and accommodation : Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to E-Mail schreiben and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Job ID REQ-10063838 Oct 09, 2025 Switzerland Summary In dieser Rolle übernehmen Sie die technische und wissenschaftliche Verantwortung für prozessspezifische Fragestellungen innerhalb der Produktion. Sie stellen sicher, dass alle Prozesse termingerecht und gemäß cGMP, SOPs sowie geltenden Richtlinien und Standards (z.-B. HSE, NOSSCE) durchgeführt werden. Darüber hinaus tragen Sie zur kontinuierlichen Verbesserung der Qualität und Effizienz bei und sichern die Geschäftskontinuität durch Ihre Expertise und Problemlösungskompetenz. #LI-Onsite Location: Muttenz, Switzerland About the Role Ihr Aufgabenbereich: Unterstützung der Produktion bei technischen und prozessspezifischen Herausforderungen in Echtzeit Sicherstellung der GMP-konformen Durchführung und Dokumentation aller Produktionsprozesse Durchführung und Pflege von Validierungen sowie relevanter Produktionsdokumente Schulung und Weiterentwicklung der Produktionsmitarbeitenden Bearbeitung von Abweichungen, Beschwerden und Umsetzung von CAPAs Mitwirkung bei Inspektionen und Einhaltung gesetzlicher Qualitäts- und HSE-Vorgaben Leitung und Unterstützung von Projekten zur kontinuierlichen Verbesserung und Technologieübertragung Definition technischer Anforderungen und Begleitung von Investitionsprojekten Förderung der Qualitäts- und HSE-Kultur am Standort Ihr Anfoderungsprofil: MSc oder PhD in organischer Chemie Mindestens zwei Jahre Erfahrung in der pharmazeutischen Industrie und in der Produktion Sehr gute Deutsch- und Englischkenntnisse Optional: Erfahrung mit Oligonukleotiden (z.-B. siRNA) Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive working environment and diverse teams, representative of the patients and communities we serve. Accessibility and accommodation : Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network (link is external) Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Operations Business Unit Innovative Medicines Location Switzerland Site Muttenz (with Canteen) Company / Legal Entity C049 (FCRS = CH049) Novartis Pharma Schweizerhalle AG Functional Area Technical Operations Job Type Full time Employment Type Regular Shift Work No Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.